-
1
-
-
0041370095
-
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
-
Ayton P.M., and Cleary M.L. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev. 17 (2003) 2298-2307
-
(2003)
Genes Dev.
, vol.17
, pp. 2298-2307
-
-
Ayton, P.M.1
Cleary, M.L.2
-
2
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
Bonnet D., and Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3 (1997) 730-737
-
(1997)
Nat. Med.
, vol.3
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
3
-
-
0346100567
-
Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
-
Cozzio A., Passegue E., Ayton P.M., Karsunky H., Cleary M.L., and Weissman I.L. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 17 (2003) 3029-3035
-
(2003)
Genes Dev.
, vol.17
, pp. 3029-3035
-
-
Cozzio, A.1
Passegue, E.2
Ayton, P.M.3
Karsunky, H.4
Cleary, M.L.5
Weissman, I.L.6
-
4
-
-
1442356729
-
CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations
-
Frohling S., Schlenk R.F., Stolze I., Bihlmayr J., Benner A., Kreitmeier S., Tobis K., Dohner H., and Dohner K. CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J. Clin. Oncol. 22 (2004) 624-633
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 624-633
-
-
Frohling, S.1
Schlenk, R.F.2
Stolze, I.3
Bihlmayr, J.4
Benner, A.5
Kreitmeier, S.6
Tobis, K.7
Dohner, H.8
Dohner, K.9
-
5
-
-
4444233646
-
C/EBPα deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo
-
Heath V., Suh H.C., Holman M., Renn K., Gooya J.M., Parkin S., Klarmann K.D., Ortiz M., Johnson P., and Keller J. C/EBPα deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo. Blood 104 (2004) 1639-1647
-
(2004)
Blood
, vol.104
, pp. 1639-1647
-
-
Heath, V.1
Suh, H.C.2
Holman, M.3
Renn, K.4
Gooya, J.M.5
Parkin, S.6
Klarmann, K.D.7
Ortiz, M.8
Johnson, P.9
Keller, J.10
-
6
-
-
19944385935
-
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
-
Huntly B.J., Shigematsu H., Deguchi K., Lee B.H., Mizuno S., Duclos N., Rowan R., Amaral S., Curley D., Williams I.R., et al. MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell 6 (2004) 587-596
-
(2004)
Cancer Cell
, vol.6
, pp. 587-596
-
-
Huntly, B.J.1
Shigematsu, H.2
Deguchi, K.3
Lee, B.H.4
Mizuno, S.5
Duclos, N.6
Rowan, R.7
Amaral, S.8
Curley, D.9
Williams, I.R.10
-
7
-
-
0035005526
-
c-Myc is a critical target for C/EBPα in granulopoiesis
-
Johansen L.M., Iwama A., Lodie T.A., Sasaki K., Felsher D.W., Golub T.R., and Tenen D.G. c-Myc is a critical target for C/EBPα in granulopoiesis. Mol. Cell. Biol. 21 (2001) 3789-3806
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3789-3806
-
-
Johansen, L.M.1
Iwama, A.2
Lodie, T.A.3
Sasaki, K.4
Felsher, D.W.5
Golub, T.R.6
Tenen, D.G.7
-
8
-
-
33748850636
-
Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block
-
Kirstetter P., Anderson K., Porse B.T., Jacobsen S.E., and Nerlov C. Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat. Immunol. 7 (2006) 1048-1056
-
(2006)
Nat. Immunol.
, vol.7
, pp. 1048-1056
-
-
Kirstetter, P.1
Anderson, K.2
Porse, B.T.3
Jacobsen, S.E.4
Nerlov, C.5
-
9
-
-
0030582532
-
Characterization of two ELISAs for NGAL, a newly described lipocalin in human neutrophils
-
Kjeldsen L., Koch C., Arnljots K., and Borregaard N. Characterization of two ELISAs for NGAL, a newly described lipocalin in human neutrophils. J. Immunol. Methods 198 (1996) 155-164
-
(1996)
J. Immunol. Methods
, vol.198
, pp. 155-164
-
-
Kjeldsen, L.1
Koch, C.2
Arnljots, K.3
Borregaard, N.4
-
10
-
-
0036785393
-
Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors
-
Kottaridis P.D., Gale R.E., Langabeer S.E., Frew M.E., Bowen D.T., and Linch D.C. Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors. Blood 100 (2002) 2393-2398
-
(2002)
Blood
, vol.100
, pp. 2393-2398
-
-
Kottaridis, P.D.1
Gale, R.E.2
Langabeer, S.E.3
Frew, M.E.4
Bowen, D.T.5
Linch, D.C.6
-
11
-
-
33746498580
-
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
-
Krivtsov A.V., Twomey D., Feng Z., Stubbs M.C., Wang Y., Faber J., Levine J.E., Wang J., Hahn W.C., Gilliland D.G., et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 442 (2006) 818-822
-
(2006)
Nature
, vol.442
, pp. 818-822
-
-
Krivtsov, A.V.1
Twomey, D.2
Feng, Z.3
Stubbs, M.C.4
Wang, Y.5
Faber, J.6
Levine, J.E.7
Wang, J.8
Hahn, W.C.9
Gilliland, D.G.10
-
12
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
Lapidot T., Sirard C., Vormoor J., Murdoch B., Hoang T., Caceres-Cortes J., Minden M., Paterson B., Caligiuri M.A., and Dick J.E. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367 (1994) 645-648
-
(1994)
Nature
, vol.367
, pp. 645-648
-
-
Lapidot, T.1
Sirard, C.2
Vormoor, J.3
Murdoch, B.4
Hoang, T.5
Caceres-Cortes, J.6
Minden, M.7
Paterson, B.8
Caligiuri, M.A.9
Dick, J.E.10
-
13
-
-
15044358998
-
CEBPA point mutations in hematological malignancies
-
Leroy H., Roumier C., Huyghe P., Biggio V., Fenaux P., and Preudhomme C. CEBPA point mutations in hematological malignancies. Leukemia 19 (2005) 329-334
-
(2005)
Leukemia
, vol.19
, pp. 329-334
-
-
Leroy, H.1
Roumier, C.2
Huyghe, P.3
Biggio, V.4
Fenaux, P.5
Preudhomme, C.6
-
14
-
-
0027420920
-
A 30-kDa alternative translation product of the CCAAT/enhancer binding protein α message: transcriptional activator lacking antimitotic activity
-
Lin F.T., MacDougald O.A., Diehl A.M., and Lane M.D. A 30-kDa alternative translation product of the CCAAT/enhancer binding protein α message: transcriptional activator lacking antimitotic activity. Proc. Natl. Acad. Sci. USA 90 (1993) 9606-9610
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 9606-9610
-
-
Lin, F.T.1
MacDougald, O.A.2
Diehl, A.M.3
Lane, M.D.4
-
15
-
-
20044388101
-
Characterization of CEBPA mutations in acute myeloid leukemia: most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells
-
Lin L.I., Chen C.Y., Lin D.T., Tsay W., Tang J.L., Yeh Y.C., Shen H.L., Su F.H., Yao M., Huang S.Y., et al. Characterization of CEBPA mutations in acute myeloid leukemia: most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells. Clin. Cancer Res. 11 (2005) 1372-1379
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 1372-1379
-
-
Lin, L.I.1
Chen, C.Y.2
Lin, D.T.3
Tsay, W.4
Tang, J.L.5
Yeh, Y.C.6
Shen, H.L.7
Su, F.H.8
Yao, M.9
Huang, S.Y.10
-
16
-
-
10744223652
-
Engraftment of acute myeloid leukemia in NOD/SCID mice is independent of CXCR4 and predicts poor patient survival
-
Monaco G., Konopleva M., Munsell M., Leysath C., Wang R.Y., Jackson C.E., Korbling M., Estey E., Belmont J., and Andreeff M. Engraftment of acute myeloid leukemia in NOD/SCID mice is independent of CXCR4 and predicts poor patient survival. Stem Cells 22 (2004) 188-201
-
(2004)
Stem Cells
, vol.22
, pp. 188-201
-
-
Monaco, G.1
Konopleva, M.2
Munsell, M.3
Leysath, C.4
Wang, R.Y.5
Jackson, C.E.6
Korbling, M.7
Estey, E.8
Belmont, J.9
Andreeff, M.10
-
17
-
-
2342544921
-
C/EBPα mutations in acute myeloid leukaemias
-
Nerlov C. C/EBPα mutations in acute myeloid leukaemias. Nat. Rev. Cancer 4 (2004) 394-400
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 394-400
-
-
Nerlov, C.1
-
18
-
-
0035093813
-
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
-
Pabst T., Mueller B.U., Zhang P., Radomska H.S., Narravula S., Schnittger S., Behre G., Hiddemann W., and Tenen D.G. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia. Nat. Genet. 27 (2001) 263-270
-
(2001)
Nat. Genet.
, vol.27
, pp. 263-270
-
-
Pabst, T.1
Mueller, B.U.2
Zhang, P.3
Radomska, H.S.4
Narravula, S.5
Schnittger, S.6
Behre, G.7
Hiddemann, W.8
Tenen, D.G.9
-
19
-
-
31544436322
-
AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML
-
Pearce D.J., Taussig D., Zibara K., Smith L.L., Ridler C.M., Preudhomme C., Young B.D., Rohatiner A.Z., Lister T.A., and Bonnet D. AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML. Blood 107 (2006) 1166-1173
-
(2006)
Blood
, vol.107
, pp. 1166-1173
-
-
Pearce, D.J.1
Taussig, D.2
Zibara, K.3
Smith, L.L.4
Ridler, C.M.5
Preudhomme, C.6
Young, B.D.7
Rohatiner, A.Z.8
Lister, T.A.9
Bonnet, D.10
-
20
-
-
0035913913
-
E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo
-
Porse B.T., Pedersen T.A., Xu X., Lindberg B., Wewer U.M., Friis-Hansen L., and Nerlov C. E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo. Cell 107 (2001) 247-258
-
(2001)
Cell
, vol.107
, pp. 247-258
-
-
Porse, B.T.1
Pedersen, T.A.2
Xu, X.3
Lindberg, B.4
Wewer, U.M.5
Friis-Hansen, L.6
Nerlov, C.7
-
21
-
-
22344437854
-
Loss of C/EBPα cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage
-
Porse B.T., Bryder D., Theilgaard-Monch K., Hasemann M.S., Anderson K., Damgaard I., Jacobsen S.E., and Nerlov C. Loss of C/EBPα cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage. J. Exp. Med. 202 (2005) 85-96
-
(2005)
J. Exp. Med.
, vol.202
, pp. 85-96
-
-
Porse, B.T.1
Bryder, D.2
Theilgaard-Monch, K.3
Hasemann, M.S.4
Anderson, K.5
Damgaard, I.6
Jacobsen, S.E.7
Nerlov, C.8
-
22
-
-
0038214755
-
Multicolor spectral karyotyping of human chromosomes
-
Schrock E., du Manoir S., Veldman T., Schoell B., Wienberg J., Ferguson-Smith M.A., Ning Y., Ledbetter D.H., Bar-Am I., Soenksen D., Garini Y., et al. Multicolor spectral karyotyping of human chromosomes. Science 273 (1996) 494-497
-
(1996)
Science
, vol.273
, pp. 494-497
-
-
Schrock, E.1
du Manoir, S.2
Veldman, T.3
Schoell, B.4
Wienberg, J.5
Ferguson-Smith, M.A.6
Ning, Y.7
Ledbetter, D.H.8
Bar-Am, I.9
Soenksen, D.10
Garini, Y.11
-
23
-
-
21744438305
-
Further evidence that germline CEBPA mutations cause dominant inheritance of acute myeloid leukaemia
-
Sellick G.S., Spendlove H.E., Catovsky D., Pritchard-Jones K., and Houlston R.S. Further evidence that germline CEBPA mutations cause dominant inheritance of acute myeloid leukaemia. Leukemia 19 (2005) 1276-1278
-
(2005)
Leukemia
, vol.19
, pp. 1276-1278
-
-
Sellick, G.S.1
Spendlove, H.E.2
Catovsky, D.3
Pritchard-Jones, K.4
Houlston, R.S.5
-
24
-
-
0036786289
-
Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: a comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse
-
Shih L.Y., Huang C.F., Wu J.H., Lin T.L., Dunn P., Wang P.N., Kuo M.C., Lai C.L., and Hsu H.C. Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: a comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse. Blood 100 (2002) 2387-2392
-
(2002)
Blood
, vol.100
, pp. 2387-2392
-
-
Shih, L.Y.1
Huang, C.F.2
Wu, J.H.3
Lin, T.L.4
Dunn, P.5
Wang, P.N.6
Kuo, M.C.7
Lai, C.L.8
Hsu, H.C.9
-
25
-
-
33646474281
-
AML patients with CEBPα mutations mostly retain identical mutant patterns but frequently change in allelic distribution at relapse: a comparative analysis on paired diagnosis and relapse samples
-
Shih L.Y., Liang D.C., Huang C.F., Wu J.H., Lin T.L., Wang P.N., Dunn P., Kuo M.C., and Tang T.C. AML patients with CEBPα mutations mostly retain identical mutant patterns but frequently change in allelic distribution at relapse: a comparative analysis on paired diagnosis and relapse samples. Leukemia 20 (2006) 604-609
-
(2006)
Leukemia
, vol.20
, pp. 604-609
-
-
Shih, L.Y.1
Liang, D.C.2
Huang, C.F.3
Wu, J.H.4
Lin, T.L.5
Wang, P.N.6
Dunn, P.7
Kuo, M.C.8
Tang, T.C.9
-
27
-
-
33749440584
-
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
-
Somervaille T.C., and Cleary M.L. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell 10 (2006) 257-268
-
(2006)
Cancer Cell
, vol.10
, pp. 257-268
-
-
Somervaille, T.C.1
Cleary, M.L.2
-
28
-
-
33750447052
-
Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells
-
Steidl U., Rosenbauer F., Verhaak R.G., Gu X., Ebralidze A., Otu H.H., Klippel S., Steidl C., Bruns I., Costa D.B., et al. Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells. Nat. Genet. 38 (2006) 1269-1277
-
(2006)
Nat. Genet.
, vol.38
, pp. 1269-1277
-
-
Steidl, U.1
Rosenbauer, F.2
Verhaak, R.G.3
Gu, X.4
Ebralidze, A.5
Otu, H.H.6
Klippel, S.7
Steidl, C.8
Bruns, I.9
Costa, D.B.10
-
29
-
-
27344435774
-
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanian A., Tamayo P., Mootha V.K., Mukherjee S., Ebert B.L., Gillette M.A., Paulovich A., Pomeroy S.L., Golub T.R., Lander E.S., et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102 (2005) 15545-15550
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
Paulovich, A.7
Pomeroy, S.L.8
Golub, T.R.9
Lander, E.S.10
-
30
-
-
0242329735
-
Evidence for allelic evolution of C/EBPα mutations in acute myeloid leukaemia
-
Tiesmeier J., Czwalinna A., Muller-Tidow C., Krauter J., Serve H., Heil G., Ganser A., and Verbeek W. Evidence for allelic evolution of C/EBPα mutations in acute myeloid leukaemia. Br. J. Haematol. 123 (2003) 413-419
-
(2003)
Br. J. Haematol.
, vol.123
, pp. 413-419
-
-
Tiesmeier, J.1
Czwalinna, A.2
Muller-Tidow, C.3
Krauter, J.4
Serve, H.5
Heil, G.6
Ganser, A.7
Verbeek, W.8
-
31
-
-
33646589342
-
Absence of the transcription factor CCAAT enhancer binding protein α results in loss of myeloid identity in bcr/abl-induced malignancy
-
Wagner K., Zhang P., Rosenbauer F., Drescher B., Kobayashi S., Radomska H.S., Kutok J.L., Gilliland D.G., Krauter J., and Tenen D.G. Absence of the transcription factor CCAAT enhancer binding protein α results in loss of myeloid identity in bcr/abl-induced malignancy. Proc. Natl. Acad. Sci. USA 103 (2006) 6338-6343
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 6338-6343
-
-
Wagner, K.1
Zhang, P.2
Rosenbauer, F.3
Drescher, B.4
Kobayashi, S.5
Radomska, H.S.6
Kutok, J.L.7
Gilliland, D.G.8
Krauter, J.9
Tenen, D.G.10
-
32
-
-
0029160028
-
Impaired energy homeostasis in C/EBPα knockout mice
-
Wang N.D., Finegold M.J., Bradley A., Ou C.N., Abdelsayed S.V., Wilde M.D., Taylor L.R., Wilson D.R., and Darlington G.J. Impaired energy homeostasis in C/EBPα knockout mice. Science 269 (1995) 1108-1112
-
(1995)
Science
, vol.269
, pp. 1108-1112
-
-
Wang, N.D.1
Finegold, M.J.2
Bradley, A.3
Ou, C.N.4
Abdelsayed, S.V.5
Wilde, M.D.6
Taylor, L.R.7
Wilson, D.R.8
Darlington, G.J.9
-
33
-
-
0033991486
-
Clinical significance of Y chromosome loss in hematologic disease
-
Wiktor A., Rybicki B.A., Piao Z.S., Shurafa M., Barthel B., Maeda K., and Van Dyke D.L. Clinical significance of Y chromosome loss in hematologic disease. Genes Chromosomes Cancer 27 (2000) 11-16
-
(2000)
Genes Chromosomes Cancer
, vol.27
, pp. 11-16
-
-
Wiktor, A.1
Rybicki, B.A.2
Piao, Z.S.3
Shurafa, M.4
Barthel, B.5
Maeda, K.6
Van Dyke, D.L.7
-
34
-
-
35948964020
-
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential
-
Wong P., Iwasaki M., Somervaille T.C., So C.W., and Cleary M.L. Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev. 21 (2007) 2762-2774
-
(2007)
Genes Dev.
, vol.21
, pp. 2762-2774
-
-
Wong, P.1
Iwasaki, M.2
Somervaille, T.C.3
So, C.W.4
Cleary, M.L.5
-
35
-
-
0031029557
-
Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice
-
Zhang D.E., Zhang P., Wang N.D., Hetherington C.J., Darlington G.J., and Tenen D.G. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice. Proc. Natl. Acad. Sci. USA 94 (1997) 569-574
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 569-574
-
-
Zhang, D.E.1
Zhang, P.2
Wang, N.D.3
Hetherington, C.J.4
Darlington, G.J.5
Tenen, D.G.6
-
36
-
-
10344230611
-
Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBPα
-
Zhang P., Iwasaki-Arai J., Iwasaki H., Fenyus M.L., Dayaram T., Owens B.M., Shigematsu H., Levantini E., Huettner C.S., Lekstrom-Himes J.A., et al. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBPα. Immunity 21 (2004) 853-863
-
(2004)
Immunity
, vol.21
, pp. 853-863
-
-
Zhang, P.1
Iwasaki-Arai, J.2
Iwasaki, H.3
Fenyus, M.L.4
Dayaram, T.5
Owens, B.M.6
Shigematsu, H.7
Levantini, E.8
Huettner, C.S.9
Lekstrom-Himes, J.A.10
|