CBFA2T2 and C20orf112: Two novel fusion partners of RUNX1 in acute myeloid leukemia

Leukemia

Volumn 24, Issue 8, 2010, Pages 1516-1519

  Guastadisegni, M C ^a   Lonoce, A ^a   Impera, L ^a   Di Terlizzi, F ^a   Fugazza, G ^b   Aliano, S ^b   Grasso, R ^b   Cluzeau, T ^c   Raynaud, S ^c   Rocchi, M ^a   Storlazzi, C T ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c PASTEUR HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; TRANSCRIPTION FACTOR RUNX1;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; CASE REPORT; CHIMERA; CHROMOSOME 21Q; GENE FUSION; HUMAN; LETTER; MALE; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 77955713862     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2010.106     Document Type: Letter

References (6)

1. De Braekeleer E, Ferec C, De Braekeleer M. RUNX1 translocations in malignant hemopathies. Anticancer Res 2009; 29: 1031-1037.
2. Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y et al. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J 1993; 12: 2715-2721.
3. Gamou T, Kitamura E, Hosoda F, Shimizu K, Shinohara K, Hayashi Y et al. The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. Blood 1998; 91: 4028-4037.
4. Richkind K, Hromas R, Lytle C, Crenshaw D, Velasco J, Roherty S et al. Identification of two new translocations that disrupt the AML1 gene. Cancer Genet Cytogenet 2000; 122: 141-143.
5. Jeandidier E, Dastugue N, Mugneret F, Lafage-Pochitaloff M, Mozziconacci MJ, Herens C et al. Abnormalities of the long arm of chromosome 21 in 107 patients with hematopoietic disorders: a collaborative retrospective study of the Groupe Francais de Cytogenetique Hematologique. Cancer Genet Cytogenet 2006; 166: 1-11.
6. Kawamata N, Ogawa S, Zimmermann M, Niebuhr B, Stocking C, Sanada M et al. Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray. Proc Natl Acad Sci USA 2008; 105: 11921-11926.