New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards α-glucosidase

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 16, 2010, Pages 5903-5914

  Pascale, Rossana ^a   Carocci, Alessia ^a   Catalano, Alessia ^a   Lentini, Giovanni ^a   Spagnoletta, Anna ^a   Cavalluzzi, Maria Maddalena ^a   De Santis, Francesco ^a   De Palma, Annalisa ^a   Scalera, Vito ^a   Franchini, Carlo ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Glucosidase; Enzyme inhibitors; Phthalimide; Structure activity relationships; Substituent effects

Indexed keywords

1 DEOXYNOJIRIMYCIN; 10 ( 2,4 DICHLOROPHENOXY)DECAN 1 OL; 10 ( 3,4 DICHLOROPHENOXY)DECAN 1 OL; 10 ( 4 CHLORO 2,6 DIMETHYLPHENOXY)DECAN 1 OL; 10 ( 4 CHLOROPHENOXY)DECAN 1 OL; 2 ( 10 PHENOXYDECYL) 1H ISOINDOLE 1,3 (2H)DIONE; 2 ( 2 PHENOXYETHYL) 1H ISOINDOLE 1,3 (2H)DIONE; 2 ( 3 PHENOXYPROPYL) 1H ISOINDOLE 1,3 (2H)DIONE; 2 ( 5 PHENOXYPENTYL) 1H ISOINDOLE 1,3 (2H)DIONE; 2 ( 6 PHENOXYHEXYL) 1H ISOINDOLE 1,3 (2H)DIONE; 2 ( 8 PHENOXYOCTYL) 1H ISOINDOLE 1,3 (2H)DIONE; 2 ( 9 PHENOXYNONYL) 1H ISOINDOLE 1,3 (2H)DIONE; 2 [ 10 ( 3,4 DICHLOROPHENOXY)DECYL] 1H ISOINDOLE 1,3 (2H)DIONE; 2 [ 10 ( 4 CHLOROPHENOXY)DECYL] 1H ISOINDOLE 1,3 (2H)DIONE; 2 [ 2 ( 4 CHLORO 2 METHYLPHENOXY)ETHYL] 1H ISOINDOLE 1,3 (2H)DIONE; 2 [ 2 ( 4 CHLOROPHENOXY)ETHYL] 1H ISOINDOLE 1,3 (2H)DIONE; 2 [ 3 ( 2,3 DICHLOROPHENOXY)PROPYL] 1H ISOINDOLE 1,3 (2H)DIONE; 2 [ 3 ( 3,4 DICHLOROPHENOXY)PROPYL] 1H ISOINDOLE 1,3 (2H)DIONE; 2 [ 3 ( 4 CHLORO 2 METHYLPHENOXY)PROPYL] 1H ISOINDOLE 1,3 (2H)DIONE; 2 [ 3 ( 4 CHLORO 2,6 DIMETHYLPHENOXY)PROPYL] 1H ISOINDOLE 1,3 (2H)DIONE; 2 [ 3 ( 4 CHLOROPHENOXY)PROPYL] 1H ISOINDOLE 1,3 (2H)DIONE; 8 PHENOXYOCTAN 1 OL; 9 PHENOXYNONAN 1 OL; ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE INHIBITOR; CARBON; CHLORINE; ISOINDOLE DERIVATIVE; PHTHALIMIDE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DERIVATIZATION; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; ELECTRON; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ALPHA-GLUCOSIDASES; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME INHIBITORS; HUMANS; PHTHALIMIDES; SACCHAROMYCES CEREVISIAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955466811     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.088     Document Type: Article

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