Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2011, Pages 5852-5860

  Arafa, Reem K ^a   Wenzler, Tanja ^b,c   Brun, Reto ^b,c   Chai, Yun ^d   David Wilson, W ^d  

^a CAIRO UNIVERSITY   (Egypt)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d GEORGIA STATE UNIVERSITY   (United States)

Author keywords

Antiprotozoal agents; Dicationic flexible triaryl guanidines; Dicationic flexible triaryl imidamides; DNA minor groove binders; Molecular modeling and docking; Thermal melting analysis

Indexed keywords

1,1' [4,4' [1,3 PHENYLENEBIS(OXY)]BIS(4,1 PHENYLENE)]BIS(N' ISOPROPYLGUANIDINE); 1,1' [4,4' [1,3 PHENYLENEBIS(OXY)]BIS(4,1 PHENYLENE)]BIS(N' METHYLGUANIDINE); 1,1' [4,4' [1,3 PHENYLENEBIS(OXY)]BIS(4,1 PHENYLENE)]DIGUANINE; 1,1' [4,4' [1,4 PHENYLENEBIS(OXY)]BIS(4,1 PHENYLENE)]BIS(N' ISOPROPYLGUANIDINE); 1,1' [4,4' [1,4 PHENYLENEBIS(OXY)]BIS(4,1 PHENYLENE)]BIS(N' METHYLGUANIDINE); 1,1' [4,4' [1,4 PHENYLENEBIS(OXY)]BIS(4,1 PHENYLENE)]DIGUANIDINE; AMIDE; ANTIPROTOZOAL AGENT; ANTITRYPANOSOMAL AGENT; GUANIDINE DERIVATIVE; N,N' [4,4' [1,3 PHENYLENEBIS(OXY)]BIS(4,1 PHENYLENE)]BIS(4 TERT BUTYLBENZIMIDAMIDE); N,N' [4,4' [1,3 PHENYLENEBIS(OXY)]BIS(4,1 PHENYLENE)]DIBENZIMIDAMIDE; N,N' [4,4' [1,3 PHENYLENEBIS(OXY)]BIS(4,1 PHENYLENE)]DIBIPHENYL 4 CARBOXIMIDAMIDE; N,N' [4,4' [1,3 PHENYLENEBIS(OXY)]BIS(4,1 PHENYLENE)]DICYCLOHEXANECARBOXIMIDAMIDE; N,N' [4,4' [1,4 PHENYLENEBIS(OXY)]BIS(4,1 PHENYLENE)]BIS(4 TERT BUTYLBENZIMIDAMIDE); N,N' [4,4' [1,4 PHENYLENEBIS(OXY)]BIS(4,1 PHENYLENE)]DIBENZIMIDAMIDE; N,N' [4,4' [1,4 PHENYLENEBIS(OXY)]BIS(4,1 PHENYLENE)]DIBIPHENYL 4 CARBOXIMIDAMIDE; N,N' [4,4' [1,4 PHENYLENEBIS(OXY)]BIS(4,1 PHENYLENE)]DICYCLOHEXANECARBOXIMIDAMIDE; PENTAMIDINE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA BINDING; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PLASMODIUM FALCIPARUM; SUBSTITUTION REACTION; THERMAL MELTING ANALYSIS; TRYPANOSOMA RHODESIENSE;

AMIDES; ANIMALS; ANTIPROTOZOAL AGENTS; CELL LINE; DNA; GUANIDINES; HUMANS; MALARIA, FALCIPARUM; MODELS, MOLECULAR; PARASITIC SENSITIVITY TESTS; PENTAMIDINE; PLASMODIUM FALCIPARUM; RATS; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN;

EID: 80955125980     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.09.047     Document Type: Article

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