Targeting the DNA minor groove with fused ring dicationic compounds: Comparison of in silico screening and a high-resolution crystal structure

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 1, 2006, Pages 15-19

  Campbell, Nancy H ^a   Evans, David A ^a,b   Lee, Michael P H ^a   Parkinson, Gary N ^a   Neidle, Stephen ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Crystallography; DNA minor groove; In silico screening; Oligonucleotide

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; DB 819; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA DETERMINATION; DNA SEQUENCE; ELECTRON TRANSPORT; GENE TARGETING; LIGAND BINDING; NONHUMAN; TRYPANOSOMA RHODESIENSE; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; DNA; IMIDAZOLES; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; SOFTWARE;

TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 27744567336     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.10.036     Document Type: Article

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