Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis

Acta Tropica

Volumn 108, Issue 1, 2008, Pages 6-10

  Thuita, J K ^a   Karanja, S M ^b   Wenzler, T ^c   Mdachi, R E ^a   Ngotho, J M ^a   Kagira, J M ^a   Tidwell, R ^d   Brun, R ^c  

^a KENYA AGRICULTURAL RESEARCH INSTITUTE   (Kenya)

^b JOMO KENYATTA UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Kenya)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

DB289; DB75; Furamidine; Human African trypanosomiasis; Mouse models; Pafuramidine; Sleeping sickness

Indexed keywords

2,5 BIS(4 AMIDINOPHENYL)FURAN; DIAMIDINE DERIVATIVE; PAFURAMIDINE; PENTAMIDINE;

ANTIMICROBIAL ACTIVITY; BIOAVAILABILITY; COMPARATIVE STUDY; DISEASE TREATMENT; DRUG; FURAN; PERFORMANCE ASSESSMENT; RODENT; TOXICITY; TRYPANOSOMIASIS;

AFRICAN TRYPANOSOMIASIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG EFFICACY; FEMALE; MOUSE; NONHUMAN; STRAIN IDENTIFICATION; TOXICITY; TRYPANOSOMA BRUCEI; TRYPANOSOMA RHODESIENSE;

ADMINISTRATION, ORAL; ANIMALS; ANTIPROTOZOAL AGENTS; BENZAMIDINES; FEMALE; HUMANS; MICE; MOLECULAR STRUCTURE; PENTAMIDINE; PRODRUGS; TRYPANOSOMA BRUCEI GAMBIENSE; TRYPANOSOMIASIS, AFRICAN;

AFRICA;

MURINAE; MUS; RODENTIA;

EID: 55149123755     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2008.07.006     Document Type: Article

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