Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs

Journal of Medicinal Chemistry

Volumn 48, Issue 17, 2005, Pages 5480-5488

  Arafa, Reem K ^a   Brun, Reto ^b   Wenzler, Tanja ^b   Tanious, Farial A ^a   Wilson, W David ^a   Stephens, Chad E ^a   Boykin, David W ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2,7 BIS(N' ETHOXYCARBONYL N'' ISOPROPYL)GUANIDINO 9H FLUORENE; 2,7 BIS(N' ETHOXYCARBONYL)GUANIDINO 9H FLUORENE; 2,7 BIS(N' ETHOXYCARBONYL)GUANIDINOFLUOREN 9 ONE; 2,7 BIS(N' ETHYL)GUANIDINO 9H FLUORENE; 2,7 BIS(N' ISOPROPYL)GUANIDINO 9H FLUORENE; 2,7 BIS(N' METHYL)GUANIDINO 9H FLUORENE; 2,7 BIS[4 (IMINOBENZYLAMINO)] 9H FLUORENE; 2,7 BIS[4 [IMINO (2 PYRIDYLMETHYL)]AMINO] 9H FLUORENE; 2,7 BISGUANIDINO 9H FLUORENE; 2,7 BISGUANIDINOANTHRAQUINONE; 2,7 BISGUANIDINOFLUOREN 9 ONE; 2,7 NIS(N ETHOXYCARBONYL N'' METHYL)GUANIDINO 9H FLUORENE; 3,6 BISGUANIDINOACRIDINE; AMIDINE; GUANIDINE DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG DNA BINDING; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA RHODESIENSE;

ANIMALS; ANTIPROTOZOAL AGENTS; CARBAMATES; CATIONS; CIRCULAR DICHROISM; DNA; FLUORENES; GUANIDINES; MICE; PLASMODIUM FALCIPARUM; POLY DA-DT; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN;

EID: 23944453324     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm058190h     Document Type: Article

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