Bisguanidine, Bis(2-aminoimidazoline), and Polyamine Derivatives as Potent and Selective Chemotherapeutic Agents against Trypanosoma brucei rhodesiense. Synthesis and in Vitro Evaluation

Journal of Medicinal Chemistry

Volumn 47, Issue 9, 2004, Pages 2296-2307

  Dardonville, Christophe ^a   Brun, Reto ^b  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 DECANEDIGUANIDINE; 1,12 DODECANEDIGUANIDINE; 1,9 NONANEDIGUANIDINE; 4,4' BIS(4,5 DIHYDRO 1H 2 IMIDAZOLYLAMINO)DIPHENYLAMINE; 4,4' BIS[1,3 BIS(TERT BUTOXYCARBONYL) 2 IMIDAZOLIDINYLIMINO]DIPHENYLAMINE; 4,4' DIGUANIDINODIPHENYLAMINE; 4,4' DIGUANIDINODIPHENYLMETHANE; ANTITRYPANOSOMAL AGENT; BIS(2 AMINOIMIDAZOLINE); BISGUANIDINE; DECAMETHYLENEDIGUANIDINE DIHYDROCHLORIDE; GUANIDINE DERIVATIVE; N1 (3 AMINOPROPYL)PROPANE 1,3 DIAMINE; POLYAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG STRUCTURE; IC 50; IN VITRO STUDY; TRYPANOSOMA BRUCEI;

ANIMALS; GUANIDINES; IMIDAZOLES; POLYAMINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 1842779964     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm031024u     Document Type: Article

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