Targeting serpins in high-throughput and structure-based drug design

Methods in Enzymology

Volumn 501, Issue , 2011, Pages 139-175

  Chang, Yi Pin ^a   Mahadeva, Ravi ^b   Patschull, Anathe O M ^c   Nobeli, Irene ^c   Ekeowa, Ugo I ^d   McKay, Adam R ^e   Thalassinos, Konstantinos ^e   Irving, James A ^d   Haq, Imran ^d   Nyon, Mun Peak ^c   Christodoulou, John ^e   Ordóñez, Adriana ^d   Miranda, Elena ^f   Gooptu, Bibek ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Allosteric targeting; Cell biology; Chemical biology; Computational biology; Drug development; Orphan diseases; Serpin; Serpin polymerization; Serpinopathies; Structural biology

Indexed keywords

PROTEIN INHIBITOR; SERINE PROTEINASE INHIBITOR; SERPIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; AUTOMATION; CONFORMATIONAL TRANSITION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HIGH THROUGHPUT SCREENING; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; SCALE UP;

EID: 80955125289     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-385950-1.00008-0     Document Type: Chapter

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