Targeting a surface cavity of α1-antitrypsin to prevent conformational disease

Journal of Biological Chemistry

Volumn 278, Issue 35, 2003, Pages 33060-33066

  Parfrey, Helen ^a,c   Mahadeva, Ravi ^a   Ravenhill, Neil A ^b   Zhou, Aiwu ^a   Dafforn, Timothy R ^a   Foreman, Richard C ^b   Lomas, David A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE CONTROL; ENZYME INHIBITION; HYDROPHOBICITY; MOLECULES; SURFACE PROPERTIES; TISSUE;

INTERMOLECULAR LINKAGES;

ENZYMES;

ALPHA 1 ANTITRYPSIN;

ALLELE; ANIMAL CELL; ARTICLE; CHROMOSOME REARRANGEMENT; CONFORMATIONAL TRANSITION; DRUG DESIGN; GENE MUTATION; GENE REARRANGEMENT; GENE TARGETING; GENETIC LINKAGE; LIVER CELL CARCINOMA; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; ROUGH ENDOPLASMIC RETICULUM; SURFACE PROPERTY;

ALPHA 1-ANTITRYPSIN; ANIMALS; BINDING SITES; CARCINOMA, HEPATOCELLULAR; CHYMOTRYPSIN; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; FIBROSIS; GLYCINE; HEPATITIS; HEPATOCYTES; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MUTATION; OOCYTES; PHENYLALANINE; POLYMERS; POTASSIUM CHLORIDE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TEMPERATURE; THREONINE; TIME FACTORS; XENOPUS;

ANIMALIA;

EID: 0042858320     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302646200     Document Type: Article

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