Local and global effects of a cavity filling mutation in a metastable serpin

Biochemistry

Volumn 48, Issue 34, 2009, Pages 8233-8240

  Sengupta, Tanusree ^a   Tsutsui, Yuko ^a   Wintrode, Patrick L ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC REGULATION; ANTITHROMBIN; CAVITY FILLING; CAVITY FILLING MUTATION; CONFORMATIONAL CHANGE; CONFORMATIONAL FLEXIBILITY; DRIVING FORCES; ELASTASE; GLOBAL EFFECTS; GLOBAL STABILITY; HYDROGEN/DEUTERIUM EXCHANGE; INHIBITORY ACTIVITY; METASTABLE FORM; MOLTEN GLOBULE; NATIVE STATE; POLYMER FORMATION; PROTEASE INHIBITION; PROTEASE INHIBITOR; SERPINS; SITE DIRECTED MUTAGENESIS; STABLE FORM; WILD TYPES;

PLASTIC FLOW;

ELASTASE; MUTANT PROTEIN; SERINE PROTEINASE INHIBITOR;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; ENZYME INHIBITOR INTERACTION; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY; PROTEINASE INHIBITION;

ALPHA 1-ANTITRYPSIN; ANIMALS; CATTLE; DEUTERIUM EXCHANGE MEASUREMENT; ENZYME INHIBITORS; GADOLINIUM; MASS SPECTROMETRY; MODELS, MOLECULAR; MUTANT PROTEINS; MUTATION; PROTEIN DENATURATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY;

EID: 69249097909     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900342d     Document Type: Article

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