-
1
-
-
0023898432
-
Molecular basis of alpha-1-antitrypsin deficiency
-
Brantly M, Nukiwa T, Crystal RG. Molecular basis of alpha-1-antitrypsin deficiency. Am J Med. 1988 84 : 13 31.
-
(1988)
Am J Med.
, vol.84
, pp. 13-31
-
-
Brantly, M.1
Nukiwa, T.2
Crystal, R.G.3
-
2
-
-
0032085755
-
Alpha1-antitrypsin deficiency, cirrhosis and emphysema
-
Mahadeva R, Lomas DA. Alpha1-antitrypsin deficiency, cirrhosis and emphysema. Thorax. 1998 53 : 501 505.
-
(1998)
Thorax.
, vol.53
, pp. 501-505
-
-
Mahadeva, R.1
Lomas, D.A.2
-
4
-
-
0021747157
-
1-proteinase inhibitor: Crystal structure analysis of two crystal modifications, molecular model, and preliminary analysis of the implications for function
-
1- proteinase inhibitor: crystal structure analysis of two crystal modifications, molecular model, and preliminary analysis of the implications for function. J Mol Biol. 1984 177 : 531 557.
-
(1984)
J Mol Biol.
, vol.177
, pp. 531-557
-
-
Loebermann, H.1
Tokuoka, R.2
Deisenhofer, J.3
-
5
-
-
0031036673
-
Major proteinase movement upon stable serpin-pro teinase complex formation
-
Stratikos E, Gettins PWG. Major proteinase movement upon stable serpin-pro teinase complex formation. Proc Natl Acad Sci USA. 1997 94 : 453 458.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 453-458
-
-
Stratikos, E.1
Gettins, P.W.G.2
-
6
-
-
0033608984
-
Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 Å and full insertion of the reactive center loop into β-Sheet A
-
Stratikos E, Gettins PWG. Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 Å and full insertion of the reactive center loop into β-Sheet A. Proc Natl Acad Sci USA. 1999 96 : 4808 4813.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 4808-4813
-
-
Stratikos, E.1
Gettins, P.W.G.2
-
7
-
-
0034687422
-
Structure of a serpin-protease complex shows inhibition by deformation
-
Huntington JA, Read RJ, Carrell RW. Structure of a serpin-protease complex shows inhibition by deformation. Nature. 2000 407 : 923 926.
-
(2000)
Nature
, vol.407
, pp. 923-926
-
-
Huntington, J.A.1
Read, R.J.2
Carrell, R.W.3
-
8
-
-
0037011795
-
1-Antitrypsin deficiency - A model for conformational diseases
-
1-Antitrypsin deficiency - A model for conformational diseases. N Eng J Med. 2002 346 : 45 53.
-
(2002)
N Eng J Med.
, vol.346
, pp. 45-53
-
-
Lomas, D.A.1
Carrell, R.W.2
-
10
-
-
0026755363
-
The mechanism of Z alpha1-antitrypsin accumulation in the liver
-
Lomas DA, Evans DL, Finch JT, et al. The mechanism of Z alpha1-antitrypsin accumulation in the liver. Nature. 1992 357 : 605 607.
-
(1992)
Nature
, vol.357
, pp. 605-607
-
-
Lomas, D.A.1
Evans, D.L.2
Finch, J.T.3
-
13
-
-
0015496403
-
Alpha1 antitrypsin in the livers of patients with emphysema
-
Lieberman J, Mittman C, Gordon HW. Alpha1 antitrypsin in the livers of patients with emphysema. Science. 1972 175 : 63 5.
-
(1972)
Science
, vol.175
, pp. 63-5
-
-
Lieberman, J.1
Mittman, C.2
Gordon, H.W.3
-
15
-
-
2442488539
-
1-Antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant
-
1- Antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant. Chest. 2004 125 : 1952 1957.
-
(2004)
Chest.
, vol.125
, pp. 1952-1957
-
-
Mulgrew, A.T.1
Taggart, C.C.2
Lawless, M.W.3
-
16
-
-
19944430698
-
1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo
-
1- antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo. Am J Pathol. 2005 166 : 377 386.
-
(2005)
Am J Pathol.
, vol.166
, pp. 377-386
-
-
Mahadeva, R.1
Atkinson, C.2
Li, Z.3
-
17
-
-
20744450475
-
Alpha1-antitrypsin deficiency
-
Stoller JK, Aboussouan LS. Alpha1-antitrypsin deficiency. Lancet. 2005 365 : 2225 2236.
-
(2005)
Lancet
, vol.365
, pp. 2225-2236
-
-
Stoller, J.K.1
Aboussouan, L.S.2
-
18
-
-
0036789017
-
Serpinopathies and the conformational dementias
-
Lomas DA, Carrell RW. Serpinopathies and the conformational dementias. Nat Rev Genet. 2002 3 : 759 768.
-
(2002)
Nat Rev Genet.
, vol.3
, pp. 759-768
-
-
Lomas, D.A.1
Carrell, R.W.2
-
19
-
-
0034721790
-
1-antitrypsin polymers are formed by reactive loop beta-sheet A linkage
-
1-antitrypsin polymers are formed by reactive loop beta-sheet A linkage. J Biol Chem. 2000 275 : 33663 33668.
-
(2000)
J Biol Chem.
, vol.275
, pp. 33663-33668
-
-
Sivasothy, P.1
Dafforn, T.R.2
Gettins, P.G.W.3
-
20
-
-
0025226070
-
Structural transition of alpha1-antitrypsin by a peptide sequentially similar to beta-strand s4A
-
Schulze AJ, Baumann U, Knof S, et al. Structural transition of alpha1-antitrypsin by a peptide sequentially similar to beta-strand s4A. Eur J Biochem. 1990 194 : 51 6.
-
(1990)
Eur J Biochem.
, vol.194
, pp. 51-6
-
-
Schulze, A.J.1
Baumann, U.2
Knof, S.3
-
21
-
-
0026701963
-
Kinetic characterization of the substrate reaction between a complex of antithrombin with a synthetic reactive-bond loop tetradecapeptide and four target proteinases of the inhibitor
-
Björk I, Nordling K, Larsson I, et al. Kinetic characterization of the substrate reaction between a complex of antithrombin with a synthetic reactive-bond loop tetradecapeptide and four target proteinases of the inhibitor. J Biol Chem. 1992 267 : 19047 19050.
-
(1992)
J Biol Chem.
, vol.267
, pp. 19047-19050
-
-
Björk, I.1
Nordling, K.2
Larsson, I.3
-
22
-
-
0029866947
-
Probing serpin reactive loop conformations by proteolytic cleavage
-
Chang WSW, Wardell MR, Lomas DA, et al. Probing serpin reactive loop conformations by proteolytic cleavage. Biochem J. 1996 314 : 647 653.
-
(1996)
Biochem J.
, vol.314
, pp. 647-653
-
-
Chang, W.S.W.1
Wardell, M.R.2
Lomas, D.A.3
-
23
-
-
0030819064
-
Mechanisms of antithrombin polymerisation and heparin activation probed by insertion of synthetic reactive loop peptides
-
Fitton HL, Pike RN, Carrell RW, et al. Mechanisms of antithrombin polymerisation and heparin activation probed by insertion of synthetic reactive loop peptides. Biol Chem. 1997 378 : 1059 1063.
-
(1997)
Biol Chem.
, vol.378
, pp. 1059-1063
-
-
Fitton, H.L.1
Pike, R.N.2
Carrell, R.W.3
-
24
-
-
0032538299
-
Implications for function and therapy of a 2.9 Å structure of binary-complexed antithrombin
-
Skinner R, Chang WSW, Jin L, et al. Implications for function and therapy of a 2.9 Å structure of binary-complexed antithrombin. J Mol Biol. 1998 283 : 9 14.
-
(1998)
J Mol Biol.
, vol.283
, pp. 9-14
-
-
Skinner, R.1
Chang, W.S.W.2
Jin, L.3
-
26
-
-
4444332086
-
How small peptides block and reverse serpin polymerization
-
Zhou A, Stein PE, Huntington JA, et al. How small peptides block and reverse serpin polymerization. J Mol Biol. 2004 342 : 931 941.
-
(2004)
J Mol Biol.
, vol.342
, pp. 931-941
-
-
Zhou, A.1
Stein, P.E.2
Huntington, J.A.3
-
27
-
-
34247626017
-
Fluorescence correlation spectroscopic study of serpin depolymerization by computationally designed peptides
-
Chowdhury P, Wang W, Lavender S, et al. Fluorescence correlation spectroscopic study of serpin depolymerization by computationally designed peptides. J Mol Biol. 2007 369 : 462 473.
-
(2007)
J Mol Biol.
, vol.369
, pp. 462-473
-
-
Chowdhury, P.1
Wang, W.2
Lavender, S.3
-
28
-
-
0037366605
-
The combinatorial synthesis of bicyclic privileged structures or privileged substructures
-
Horton DA, Bourne GT, Smythe ML. The combinatorial synthesis of bicyclic privileged structures or privileged substructures. Chem Rev. 2003 103 : 893 930.
-
(2003)
Chem Rev.
, vol.103
, pp. 893-930
-
-
Horton, D.A.1
Bourne, G.T.2
Smythe, M.L.3
-
29
-
-
0032807739
-
Combinatorial approaches to materials design
-
McFarland EW, Weinberg WH. Combinatorial approaches to materials design. TIBTECH. 1999 17 : 107 115.
-
(1999)
TIBTECH.
, vol.17
, pp. 107-115
-
-
McFarland, E.W.1
Weinberg, W.H.2
-
30
-
-
33750449952
-
A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide
-
Kim W, Kim Y, Min J, et al. A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide. ACS Chem Biol. 2006 1 : 461 469.
-
(2006)
ACS Chem Biol.
, vol.1
, pp. 461-469
-
-
Kim, W.1
Kim, Y.2
Min, J.3
-
32
-
-
0036007197
-
Combinatorial chemistry: 20 years on
-
Furka Á. Combinatorial chemistry: 20 years on. Drug Discov Today. 2002 7 : 1 7.
-
(2002)
Drug Discov Today.
, vol.7
, pp. 1-7
-
-
Furka, Á.1
-
35
-
-
0017868338
-
Empirical predictions of protein conformation
-
Chou PY, Fasman GD. Empirical predictions of protein conformation. Annu Rev Biochem. 1978 47 : 251 276.
-
(1978)
Annu Rev Biochem.
, vol.47
, pp. 251-276
-
-
Chou, P.Y.1
Fasman, G.D.2
-
36
-
-
0028577207
-
An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library
-
Dooley CT, Chung NN, Wilkes BC, et al. An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library. Science. 1994 266 : 2019 2022.
-
(1994)
Science
, vol.266
, pp. 2019-2022
-
-
Dooley, C.T.1
Chung, N.N.2
Wilkes, B.C.3
-
37
-
-
0031573094
-
Tight-binding streptavidin ligands from a cyclic peptide library
-
Yu Z, Tu J, Chu YH. Tight-binding streptavidin ligands from a cyclic peptide library. Anal Chem. 1997 69 : 4515 4518.
-
(1997)
Anal Chem.
, vol.69
, pp. 4515-4518
-
-
Yu, Z.1
Tu, J.2
Chu, Y.H.3
-
38
-
-
0042121237
-
Multiple sequence alignment with the Clustal series of programs
-
Chenna R, Sugawara H, Koike T, et al. Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 2003 31 : 3497 3500.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 3497-3500
-
-
Chenna, R.1
Sugawara, H.2
Koike, T.3
-
39
-
-
33845931650
-
Survey of the year 2005 commercial optical biosensor literature
-
Rich RL, Myszka DG. Survey of the year 2005 commercial optical biosensor literature. J Mol Recognit. 2006 19 : 478 534.
-
(2006)
J Mol Recognit.
, vol.19
, pp. 478-534
-
-
Rich, R.L.1
Myszka, D.G.2
-
40
-
-
15544374363
-
Using surface plasmon resonance to directly determine binding affinities of combinatorially selected cyclopeptides and their linear analogs to a streptavidin chip
-
Chang YP, Chu YH. Using surface plasmon resonance to directly determine binding affinities of combinatorially selected cyclopeptides and their linear analogs to a streptavidin chip. Anal Biochem. 2005 340 : 74 9.
-
(2005)
Anal Biochem.
, vol.340
, pp. 74-9
-
-
Chang, Y.P.1
Chu, Y.H.2
-
41
-
-
33750614316
-
Using surface plasmon resonance to directly measure slow binding of low-molecular mass inhibitors to a VanX chip
-
Chang YP, Tseng MJ, Chu YH. Using surface plasmon resonance to directly measure slow binding of low-molecular mass inhibitors to a VanX chip. Anal Biochem. 2006 359 : 63 71.
-
(2006)
Anal Biochem.
, vol.359
, pp. 63-71
-
-
Chang, Y.P.1
Tseng, M.J.2
Chu, Y.H.3
-
42
-
-
35848929750
-
1- antitrypsin and increase the clearance of intracellular aggregates
-
1-antitrypsin and increase the clearance of intracellular aggregates. J Med Chem. 2007 50 : 5357 5363.
-
(2007)
J Med Chem.
, vol.50
, pp. 5357-5363
-
-
Mallya, M.1
Phillips, R.L.2
Saldanha, S.A.3
-
43
-
-
0022591495
-
The classification of amino acid conservation
-
Taylor WR. The classification of amino acid conservation. J Theor Biol. 1986 119 : 205 218.
-
(1986)
J Theor Biol.
, vol.119
, pp. 205-218
-
-
Taylor, W.R.1
-
44
-
-
3342889562
-
Different conformational changes within the F-Helix occur during serpin folding, polymerization, and proteinase inhibition
-
Cabrita LD, Dai W, Bottomley SP. Different conformational changes within the F-Helix occur during serpin folding, polymerization, and proteinase inhibition. Biochemistry. 2004 43 : 9834 9839.
-
(2004)
Biochemistry.
, vol.43
, pp. 9834-9839
-
-
Cabrita, L.D.1
Dai, W.2
Bottomley, S.P.3
-
45
-
-
0034976979
-
1-antitrypsin that play structural and functional roles
-
1- antitrypsin that play structural and functional roles. Protein Sci. 2001 10 : 1446 1453.
-
(2001)
Protein Sci.
, vol.10
, pp. 1446-1453
-
-
Lee, C.1
Maeng, J.S.2
Kocher, J.P.3
-
46
-
-
0036433482
-
1- antitrypsin deficiency
-
1-antitrypsin deficiency. Chest. 2002 122 : 1818 1829.
-
(2002)
Chest.
, vol.122
, pp. 1818-1829
-
-
De Serres, F.J.1
-
47
-
-
0038216603
-
Augmentation therapy with alpha1-antitrypsin: Patterns of use and adverse events
-
Stoller JK, Fallat R, Schluchter MD, et al. Augmentation therapy with alpha1-antitrypsin: patterns of use and adverse events. Chest. 2003 123 : 1425 1434.
-
(2003)
Chest.
, vol.123
, pp. 1425-1434
-
-
Stoller, J.K.1
Fallat, R.2
Schluchter, M.D.3
-
48
-
-
0037952677
-
Cost-effectiveness analysis of augmentation therapy for severe alpha1-antitrypsin deficiency
-
Gildea TR, Shermock KM, Singer ME, et al. Cost-effectiveness analysis of augmentation therapy for severe alpha1-antitrypsin deficiency. Am J Respir Crit Care Med. 2003 167 : 1387 1392.
-
(2003)
Am J Respir Crit Care Med.
, vol.167
, pp. 1387-1392
-
-
Gildea, T.R.1
Shermock, K.M.2
Singer, M.E.3
|