Thioredoxin glutathione reductase: Its role in redox biology and potential as a target for drugs against neglected diseases

Biochimica et Biophysica Acta - General Subjects

Volumn 1810, Issue 12, 2011, Pages 1262-1271

  Prast Nielsen, Stefanie ^a   Huang, Hsin Hung ^b   Williams, David L ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Drug development; Flavoprotein oxidoreductase; Glutathione; Schistosomiasis; Selenocysteine; Thioredoxin

Indexed keywords

AURANOFIN; ENZYME INHIBITOR; FURAZOLIDONE; GLUTATHIONE REDUCTASE; PRAZIQUANTEL; SELENOCYSTINE; SELENOPROTEIN; THIOREDOXIN GLUTATHIONE REDUCTASE; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

CESTODIASIS; DOSE RESPONSE; DRUG RESEARCH; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; EUKARYOTE; GENE; GENE STRUCTURE; HUMAN; NEGLECTED DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION POTENTIAL; PLATYHELMINTH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVIEW; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SCHISTOSOMIASIS JAPONICA; SCHISTOSOMIASIS MANSONI; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; THIOREDOXIN GLUTATHIONE REDUCTASE GENE; TREMATODIASIS;

ANIMALS; HUMANS; MULTIENZYME COMPLEXES; NADH, NADPH OXIDOREDUCTASES; OXIDATION-REDUCTION;

ANIMALIA; CESTODA; PLATYHELMINTHES; TREMATODA;

EID: 80855138132     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2011.06.024     Document Type: Review

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