Reactivity of the human thioltransferase (glutaredoxin) C7S, C25S, C78S, C82S mutant and NMR solution structure of its glutathionyl mixed disulfide intermediate reflect catalytic specificity

Biochemistry

Volumn 37, Issue 49, 1998, Pages 17145-17156

  Yang, Yanwu ^a   Jao, Shu Chuan ^a,c   Nanduri, Sambasivarao ^a   Starke, David W ^b   Mieyal, John J ^b,c   Qin, Jun ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXIDOREDUCTASE; TRANSFERASE;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ESCHERICHIA COLI; GLUTATHIONE DISULFIDE; HUMANS; LIVER; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXIDOREDUCTASES; PROTEIN DISULFIDE REDUCTASE (GLUTATHIONE); PROTEIN STRUCTURE, SECONDARY; PROTEINS; SERINE; SOLUTIONS; SUBSTRATE SPECIFICITY; SWINE;

EID: 0032497928     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9806504     Document Type: Article

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