Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells

Journal of Biological Chemistry

Volumn 281, Issue 9, 2006, Pages 5593-5603

  Cenas, Narimantas ^a   Prast, Stefanie ^b   Nivinskas, Henrikas ^a   Sarlauskas, Jonas ^a   Arnér, Elias S J ^b  

^a VILNIUS UNIVERSITY   (Lithuania)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; DRUG INTERACTIONS; ENZYME INHIBITION; ONCOLOGY; SUBSTRATES;

HUMAN CANCER CELLS; NITROAROMATIC COMPOUNDS; NITROAROMATIC SUBSTRATES; NITROREDUCTASE; SELENOPROTEIN THIOREDOXIN REDUCTASE;

CELLS;

1 CHLORO 2,4 DINITROBENZENE; 2,4 DINITROPHENYL N METHYLNITRAMINE; 4,6 DINITROBENZOFUROXAN; 5,5' DITHIOBIS(2 NITROBENZOIC ACID); AMINE; AROMATIC NITRO COMPOUND; BENZOXAZOLE DERIVATIVE; CYTOCHROME C; DISULFIDE; JUGLONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SELENOLTHIOL; SELENOPROTEIN; THIOL DERIVATIVE; THIOREDOXIN; UNCLASSIFIED DRUG; CASP3 PROTEIN, HUMAN; CASP7 PROTEIN, HUMAN; CASPASE; CASPASE 3; CASPASE 7; ENZYME INHIBITOR; NAPHTHOQUINONE; NITROBENZENE DERIVATIVE; NITROGEN DERIVATIVE; PROTEIN BCL 2; SUPEROXIDE; THIOL REAGENT; THIOREDOXIN REDUCTASE;

APOPTOSIS; ARTICLE; CANCER CELL; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; ANIMAL; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; ENZYME ACTIVATION; GENETICS; METABOLISM; NEOPLASM; OXIDATION REDUCTION REACTION; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

MAMMALIA;

ANIMALS; APOPTOSIS; BINDING SITES; CASPASE 3; CASPASE 7; CASPASES; CELL LINE, TUMOR; DINITROBENZENES; DITHIONITROBENZOIC ACID; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; NAPHTHOQUINONES; NEOPLASMS; NITROGEN COMPOUNDS; OXIDATION-REDUCTION; PROTO-ONCOGENE PROTEINS C-BCL-2; SULFHYDRYL REAGENTS; SUPEROXIDES; THIOREDOXIN REDUCTASE (NADPH);

EID: 33646806762     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M511972200     Document Type: Article

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