Comparative modeling of thioredoxin glutathione reductase from Schistosoma mansoni: A multifunctional target for antischistosomal therapy

Journal of Molecular Graphics and Modelling

Volumn 27, Issue 6, 2009, Pages 665-675

  Sharma, Monika ^a   Khanna, Smriti ^a   Bulusu, Gopalakrishnan ^b   Mitra, Abhijit ^a  

^a INTERNATIONAL INSTITUTE OF INFORMATION TECHNOLOGY   (India)

^b TATA CONSULTANCY SERVICES   (India)

Author keywords

Docking; Glutathione disulfide; Homology modeling; Schistosoma mansoni; Thioredoxin glutathione reductase

Indexed keywords

BINDING POCKETS; COFACTORS; COMPARATIVE ANALYSIS; COMPARATIVE MODELING; DRUG TARGETS; ESSENTIAL COMPONENTS; GLUTATHIONE DISULFIDE; HOMOLOGY MODELING; HOMOLOGY MODELS; PARASITE-; REACTIVE OXYGEN SPECIES; REDOX ACTIVITIES; REDOX MECHANISMS; REDOX SYSTEMS; SCHISTOSOMA MANSONI; SELENOCYSTEINE; THIOREDOXIN GLUTATHIONE REDUCTASE; THIOREDOXIN REDUCTASE; X-RAY STRUCTURES;

DOCKING; ELECTRIC GROUNDING; MODEL STRUCTURES; OXYGEN;

PROTEINS;

FLAVINE ADENINE NUCLEOTIDE; GLUTATHIONE REDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SELENOCYSTEINE; THIOREDOXIN;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; SCHISTOSOMA MANSONI; X RAY ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIPROTOZOAL AGENTS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ELECTRON TRANSPORT; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; NADH, NADPH OXIDOREDUCTASES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SCHISTOSOMA MANSONI; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY;

SCHISTOSOMA MANSONI; TREMATODA;

EID: 58849122630     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmgm.2008.10.009     Document Type: Article

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