Product of the Schistosoma mansoni Glutathione Peroxidase Gene is a Selenium Containing Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx) Sharing Molecular Weight and Substrate Specificity with Its Mammalian Counterpart

Biomedical and Environmental Sciences

Volumn 10, Issue 2-3, 1997, Pages 209-213

  Maiorino, Matilde ^a   Pierce, Raymond ^b   Flohé, Leopold ^c  

^a UNIVERSITY OF PADOVA   (Italy)

^b INSTITUT PASTEUR DE LILLE   (France)

^c TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE PEROXIDASE; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE;

AMINO ACID SEQUENCE; ANIMAL; CATTLE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; MOLECULAR GENETICS; MOLECULAR WEIGHT; REVIEW; SCHISTOSOMA MANSONI; SEQUENCE HOMOLOGY; SWINE;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; GLUTATHIONE PEROXIDASE; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; SCHISTOSOMA MANSONI; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; SWINE;

EID: 0031227820     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Brigelius-Flohé, R., Aumann, K. D., Blöcker, H., Gross, G., Kiess, M., Klöppel, K. D., Maiorino, M., Roveri, A., Schucklet, R., Ursini, F., Wingender, E., and Flohé, L. (1994). Phospholipid Hydroperoxide Glutathione Peroxidase: Genomic DNA, cDNA and deduced amino acid sequence. J. Biol. Chem., 269, 7342-7348.
2. Flohé, L., Günzler, W. A., and Schock H. H. (1973). Glutathione peroxidase: A selenoenzyme. FEBS lett. 32, 132-134.
3. Flohé, L. (1989). The selenoprotein glutathione peroxidase. In Glutathione: Chemical, biochemical, and medical aspects (D. Dolphin, R. Poulson and A. Avramovic, Eds.), pp. 643-731. John Wiley & Sons, Inc., New York.
4. Lei, X. G., Evenson, J. K., Thompson, K. M., and Sunde R. A. (1995). Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are differentially regulated in rats by dietary selenium. J. Nutr. 125, 1438-1466.
5. Maiorino, M., Coassin, M., Roveri, A., and Ursini, F. (1989). Microsomal lipid peroxidation: Effect of vitamin E and its functional interactions with phospholipid hydroperoxide glutathione peroxidase. Lipids 24, 721-726.
6. Maiorino, M., Roveri, A., and Ursini, F. (1993). Phospholipid hydroperoxide glutathione peroxidase is the major selenoperoxidase in nuclei and mitochondria of rat testis. In Free Radicals From Basic Science to Medicine, (G. Poli, E. Albano, and M.U. Dianzani, Eds.), pp. 412-418. Birkhäuser Verlag, Basel.
7. Maiorino, M., Aumann, K-D., Brigelius-Flohé, R., Doria, D., van Den Heuvel, J., McCarthy, J., Roveri, A., Ursini, F., and Flohé, L. (1995), Probing the presumed catalytic triad of selenim-containing peroxidases by mutational analysis of phospholipid hydroperoxide glutathione peroxidase (PHGPx). Biol. Chem. Hoppe-Seyler 376, 651-660.
8. Maiorino, M., Roche, C., Kiess, M., Koenig, K., Gawlik, D., Matthes, M., Naldini, E., Pierce, R., and Flohé, L. (1996). A selenium containing phospholipid hydroperoxide glutathione peroxidase in Schistosoma mansoni. Eur. J. Biochem. 238, 838-844.
9. Roche, C., Williams, D. L., Khalife, J., LePresle, T., Capron, A., and Pierce, R. J. (1994). Cloning and characterization of gene encoding Schistosoma mansoni glutathione peroxidase. Gene 138, 149-152.
10. Roche, C., Liu, J. L., LePresle, T., Capron, A., and Pierce, R. J. (1996). Tissue localization and stage-specific expression of the phospholipid hydroperoxide glutathione peroxidase of Schistosoma mansoni. Mol. Biochem. Parasitol. 75, 187-195.
11. Roveri, A., Casasco, A., Maiorino, M., Dalan, P., Calligaro, A., and Ursini, F. (1992). Phospholipid hydroperoxide glutathione peroxidase of rat testis: gonadotropin dependency and immunocytochernical identification. J. Biol. Chem. 267, 6142-6146.
12. Roveri, A., Maiorino, M., Nisii, C., and Ursini, F. (19941). Purification and characterization of phospholipid hydroperoxide glutathione peroxidase from rat testis mitochondrial membranes. Biochim. Biophys. Acta 1208, 211-221.
13. Roveri, A., Maiorino, M., and Ursini, F. (1994 II). Enzymatic and immunological measurements of soluble and membrane bound PHGPx. Methods Enzymol. 233, 202-212.
14. Schuckelt, R., Brigelius-Flohé, R., Maiorino, M., Roveri, A., Reumkens, J., Strassburger, W., Ursini, F., Wolf, B., and Flohé L. (1991). Phospholipid hydroperoxide glutathione peroxidase is a selenoenzyme distinct from the classical glutathione peroxidase as evident from cDNA and ammo acid sequencing. Free Rad. Res. Commun. 14, 343-361.
15. Ursini, F., Maiorino, M., and Gregolin, C. (1985). The selenoenzyme phospholipid hydroperoxide glutathione peroxidase. Biochim. Biophys. Acta 839, 62-70.
16. Ursini, F., Maiorino, M., and Sevanian, A. (1991). Membrane hydroperoxides. In Oxidative Stress: Oxidants and Antioxidants (H. Sies, Ed.), pp. 319-336. Academic Press, London.
17. Ursini, F., Maiorino, M., Brigelius-Flohé, R., Aumann, K.D., Roveri, A., Schomburg, D., and L. Flohé. (1995). The diversity of glutathione peroxidases. Methods Enzymol. 252, 38-53.