Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni

Biochemistry

Volumn 50, Issue 26, 2011, Pages 5870-5882

  Huang, Hsin Hung ^a   Day, Latasha ^a   Cass, Cynthia L ^b   Ballou, David P ^c   Williams, Charles H ^c   Williams, David L ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b ILLINOIS STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ANAEROBIC TITRATION; CATALYTIC MECHANISMS; DITHIOLS; DRUG TARGETS; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; HIGH CONCENTRATION; IN-LINE; PARASITE-; REDOX-ACTIVE; SCHISTOSOMA MANSONI; SELENOCYSTEINE; STEADY-STATE KINETICS; THIOLATES; THIOREDOXIN GLUTATHIONE REDUCTASE; THIOREDOXIN REDUCTASE; THIOREDOXINS; WILD TYPES;

AMINO ACIDS; CATALYSIS; ENZYMES;

SUBSTRATES;

CYSTEINE; DISULFIDE; GLUTAREDOXIN; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SCHISTOSOMA MANSONI THIOREDOXIN GLUTATHIONE REDUCTASE; SELENOCYSTEINE; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CHEMICAL REACTION; DEGLUTATHIONYLATION; ENZYME ACTIVITY; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS;

ANIMALS; BIOCATALYSIS; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; NADH, NADPH OXIDOREDUCTASES; PROTEIN STRUCTURE, TERTIARY; SCHISTOSOMA MANSONI; SELENOCYSTEINE;

SCHISTOSOMA MANSONI;

EID: 79959805617     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200107n     Document Type: Article

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