Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T

Radiotherapy and Oncology

Volumn 101, Issue 1, 2011, Pages 190-197

  Ramaekers, Chantal H M A ^a,b   Van Den Beucken, Twan ^a,b   Meng, Alice ^a   Kassam, Shaqil ^a   Thoms, John ^a   Bristow, Robert G ^a,c   Wouters, Bradly G ^a,b,c  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

FANCD2; HIF; Hypoxia; UBE2T

Indexed keywords

DNA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; MITOMYCIN C; OXYGEN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE UBE2T; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL HYPOXIA; CELL STRAIN MCF 7; CELL SURVIVAL; CHEMOTHERAPY; CONTROLLED STUDY; DNA REPAIR; DOWN REGULATION; FANCONI ANEMIA; FEMALE; GENE EXPRESSION; GENOMIC INSTABILITY; HELA CELL; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN MICROARRAY; PROTEIN STABILITY; QUANTITATIVE ANALYSIS; SENSITIZATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANOXIA; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL SURVIVAL; DNA REPAIR; DOWN-REGULATION; FANCONI ANEMIA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; REFERENCE VALUES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; UBIQUITIN-CONJUGATING ENZYMES;

EID: 80655144415     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.05.059     Document Type: Article

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