Determination of testosterone metabolites in human hepatocytes I. Development of an on-line sample preparation liquid chromatography technique and mass spectroscopic detection of 6β-hydroxytestosterone

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 784, Issue 1, 2003, Pages 49-61

  Friedrich, Gerhard ^a   Rose, Thorsten ^a   Rissler, Klaus ^b  

^a Institute of Contract Research   (Germany)

^b NONE   (Germany)

Author keywords

6 Hydroxytestosterone; Testosterone

Indexed keywords

ATMOSPHERIC PRESSURE; IONIZATION; LIQUID CHROMATOGRAPHY; METABOLITES;

SIGNAL MONOTORING;

BIOTECHNOLOGY;

6BETA HYDROXYTESTOSTERONE; BIOMATERIAL; CARBON; CORTICOSTERONE; METHANOL; SULFAMIDOCHRYSOIDINE; TESTOSTERONE DERIVATIVE; TETRAHYDROFURAN; UNCLASSIFIED DRUG; WATER;

ACCURACY; ARTICLE; CONCENTRATION RESPONSE; EXTRACTION; FREEZING; HORMONE DETERMINATION; HUMAN; INJECTION; ION MONITORING; LINEAR SYSTEM; LIVER CELL; MASS SPECTROMETRY; METABOLITE; ONLINE SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SAMPLE; SEPARATION TECHNIQUE; STORAGE; TESTOSTERONE METABOLISM; THAWING;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEPATOCYTES; HUMANS; MASS SPECTROMETRY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TESTOSTERONE;

CICONIIFORMES;

EID: 0037464622     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(02)00754-7     Document Type: Article

References (34)

1. Thomas P.E., Reik L.M., Ryan D.E., Levin W. J. Biol. Chem. 256:1981;1044.
2. Ryan D.E., Thomas P.E., Reik L.M., Levin W. Xenobiotica. 12:1982;727.
3. Guengerich F.P., Martin M.V., Beaune P.H., Kremers P., Wolff T., Waxman D.J. J. Biol. Chem. 261:1986;5051.
4. Waxman D.J., Attisano C., Guengerich F.P., Lapenson D.P. Arch. Biochem. Biophys. 263:1988;424.
5. Guengerich F.P., Shimada T. Chem. Res. Toxicol. 4:1991;391.
6. Nelson D.R., Koymanns L., Kamataki T., Stegemann J.J., Feyereisen R., Waxman D.J., Waterman M.R., Gotoh O., Coon M.J., Estabrook R.W., Gunsalus I.C., Nebert D.W. Pharmacogenetics. 6:1996;1.
7. van der Hoven T. Biochem. Biophys. Res. Commun. 100:1981;1285.
8. Wood A.W., Ryan D.E., Thomas P.E., Levin W. J. Biol. Chem. 258:1983;8839.
9. Kern A., Bader A., Pichlmayr R., Sewing K.-F. Biochem. Pharmacol. 54:1997;761.
10. Sonderfan A.J., Arlotto M.P., Dutton D., McMillen S.K., Parkinson A. Arch. Biochem. Biophys. 255:1987;27.
11. Waxman D.J., Attisano C., Guengerich F.P., Lapenson D.P. Arch. Biochem. Biophys. 263:1988;424.
12. Arlotto M.P., Trant J.M., Estabrook R.W. Methods Enzymol. 206:1991;454.
13. Waxman D.J. Methods Enzymol. 206:1991;462.
14. Van Der Hoeven T. Anal. Biochem. 138:1984;57.
15. Woertelboer H.M., de Kruif C.A., van Iersel A.A.J., Falke H.E., Noordhoek J., Blaauboer B.J. Biochem. Pharmacol. 40:1990;2525.
16. Williams T.M., Kind A.J., Hill D.W. J. Vet. Pharmacol. Ther. 23:2000;57.
17. Khalil M.W., Lawson V. Steroids. 41:1983;549.
18. Andersson S.H.G., Sjövall J. J. Steroid Biochem. 23:1985;469.
19. Daeseleire E.A.I., de Guesquière A., van Peterghem C.H. J. Chromatogr. Sci. 30:1992;409.
20. Hayata K., Hayashi N., Sekiba K. Acta Med. Okayama. 39:1985;161.
21. Laganà A., Marino A. J. Chromatogr. 588:1991;89.
22. Navajas R., Imaz C., Carreras D., García M., Pérez M., Rodríguez C., Rodríguez A.F., Cortés R. J. Chromatogr. B. 673:1995;159.
23. Smith S.J., Korzewka K.R., Aoyama T., Gonzalez F.J., Darbyshire J.F., Sugiyama K., Gillette J.R. Drug Metabol. Dispos. 20:1992;566.
24. Sanwald P., Blankson E.A., Duléry B.D., Schoun J., Huebert N.D., Dow J. J. Chromatogr. B. 672:1995;207.
25. Baltes M.R.H., Dubois J.G., Hancoq M. J. Chromatogr. B. 706:1998;201.
26. Stolker A.A.M., van Ginkel L.A., Stephany R.W., Maxwell R.J., Parks O.W., Lightfield A.R. J. Chromatogr. B. 726:1999;121.
27. Ekins S., Murray G.I., Burke M.D., Williams J.A., Marchant N.C., Hawksworth G.M. Drug Metabol. Dispos. 23:1995;1274.
28. Shou M., Lu T., Krausz K.W., Sai Y., Yang T., Korzekwa K.R., Gonzalez F.J., Gelboin H.V. Eur. J. Pharmacol. 394:2000;199.
29. Draisci R., Giannetti L., Lucentini L., Palleschi L., Purificato I., Moretti G. J. High Resolut. Chromatogr. 20:1997;421.
30. Draisci R., Palleschi L., Ferretti E., Lucentini L., Cammarata P. J. Chromtogr. A. 870:2000;511.
31. Tachibana S., Tanaka M. Anal. Biochem. 295:2001;248.
32. Fernandez C., Egginger G., Wainer I.W., Lloyd D.K. J. Chromatogr. B. 677:1996;363.
33. Friedrich G., Rose T., Rissler K. J. Chromatogr. B. 766:2002;295.
34. Roth W., Beschke K., Jauch R., Zimmer A., Koss F.W. J. Chromatogr. 222:1981;13.