Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats

Journal of Pharmacy and Pharmacology

Volumn 62, Issue 8, 2010, Pages 1077-1083

  Wang, Xin ^a   Yeung, John H K ^a  

^a Chinese University of Hong Kong   (Hong Kong)

Author keywords

caffeine; competitive inhibition; CYP1A2; Danshen

Indexed keywords

3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; CAFFEINE; CIMETIDINE; CYTOCHROME P450 1A2; FURAFYLLINE; PARAXANTHINE; PHENACETIN; PROTOCATECHUALDEHYDE; ROSMARINIC ACID; SALVIA MILTIORRHIZA EXTRACT; SALVIANOLIC ACID B;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; BLOOD CHEMISTRY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG HALF LIFE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LIVER CLEARANCE; LIVER MICROSOME; LIVER MICROSOME METABOLISM; MALE; METABOLITE; NONHUMAN; PLANT ROOT; PLASMA CLEARANCE; RAT; SINGLE DRUG DOSE;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOTRANSFORMATION; CAFFEINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A2; CYTOCHROMES; DRUGS, CHINESE HERBAL; ENZYME INHIBITORS; HALF-LIFE; HUMANS; INJECTIONS, INTRAPERITONEAL; LIVER; MALE; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA; SUBSTRATE SPECIFICITY; THEOPHYLLINE;

EID: 77954933481     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2010.01127.x     Document Type: Article

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