Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates

Phytomedicine

Volumn 16, Issue 8, 2009, Pages 712-725

  Wang, Xin ^a   Lee, Wayne Y W ^a   Or, Penelope M Y ^a   Yeung, John H K ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

Competitive inhibition of CYP1A2 probes; CYP1A2; Danshen; Expression; Tanshinones

Indexed keywords

CAFFEINE; CRYPTOTANSHINONE; CYTOCHROME P450 1A2; DIHYDROTANSHINONE; FURAFYLLINE; PARAXANTHINE; PHENACETIN; PHENACETIN O DEETHYLASE; PLANT MEDICINAL PRODUCT; SALVIA MILTIORRHIZA EXTRACT; TANSHINONE; TANSHINONE I; TANSHINONE IIA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG HALF LIFE; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MALE; METABOLISM; NONHUMAN; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SALVIA MILTIORRHIZA; WESTERN BLOTTING;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; CYTOCHROME P-450 CYP1A2; DRUGS, CHINESE HERBAL; HALF-LIFE; MALE; METABOLIC CLEARANCE RATE; PHENACETIN; PHENANTHRENES; PHENANTHROLINES; PLANT EXTRACTS; PLANT ROOTS; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA;

RATTUS; SALVIA MILTIORRHIZA;

EID: 67349217348     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.03.004     Document Type: Article

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