A pharmacodynamic-pharmacokinetic (PD-PK) study on the effects of Danshen (Salvia miltiorrhiza) on midazolam, a model CYP3A probe substrate, in the rat

Phytomedicine

Volumn 17, Issue 11, 2010, Pages 876-883

  Wang, Xin ^a   Lee, Wayne Y W ^a   Zhou, Xuelin ^a   Or, Penelope M Y ^a   Yeung, John H K ^a  

^a Prince of Wales Hospital   (Hong Kong)

Author keywords

CYP3A; Danshen (Salvia miltiorrhiza); Midazolam pharmacodynamics pharmacokinetics in vivo; Rat

Indexed keywords

3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; ALPHA HYDROXYMIDAZOLAM; CRYPTOTANSHINONE; CYTOCHROME P450 3A; DIHYDROTANSHINONE; MIDAZOLAM; PHENOBARBITAL; PROTOCATECHUALDEHYDE; ROSMARINIC ACID; SALVIA MILTIORRHIZA EXTRACT; SALVIANOLIC ACID B; TANSHINONE; TANSHINONE I; TANSHINONE IIA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG HALF LIFE; ENZYME INDUCTION; ENZYME SUBSTRATE; HERB DRUG INTERACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPNOSIS; IN VIVO STUDY; LOW DRUG DOSE; MALE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; SALVIA MILTIORRHIZA; SLEEP TIME;

RATTUS; SALVIA MILTIORRHIZA;

EID: 77955983969     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.05.007     Document Type: Article

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