Pharmacokinetic interaction studies of tanshinones with tolbutamide, a model CYP2C11 probe substrate, using liver microsomes, primary hepatocytes and in vivo in the rat

Phytomedicine

Volumn 17, Issue 3-4, 2010, Pages 203-211

  Wang, X ^a   Lee, W Y W ^a   Or, P M Y ^a   Yeung, J H K ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

4 Hydroxy tolbutamide; Danshen (Salvia miltiorrhiza); Rat CYP2C11 activity; Tanshinones; Tolbutamide metabolism

Indexed keywords

CRYPTOTANSHINONE; CYTOCHROME P450 2C11; DIHYDROTANSHINONE; SALVIA MILTIORRHIZA EXTRACT; TANSHINONE; TANSHINONE I; TANSHINONE IIA; TOLBUTAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DRUG SCREENING; ENZYME KINETICS; HERB DRUG INTERACTION; HYDROXYLATION; IN VIVO STUDY; LIVER CELL; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SALVIA MILTIORRHIZA;

ANIMALS; AREA UNDER CURVE; ARYL HYDROCARBON HYDROXYLASES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; HERB-DRUG INTERACTIONS; HYDROXYLATION; MALE; METABOLIC CLEARANCE RATE; METABOLIC DETOXICATION, DRUG; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; MODELS, ANIMAL; PHENANTHRENES; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA; STEROID 16-ALPHA-HYDROXYLASE; TOLBUTAMIDE;

ANIMALIA; RATTUS; SALVIA MILTIORRHIZA;

EID: 75249084372     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.07.013     Document Type: Article

References (31)

1. Chan K., Lo A.C.T., Yeung J.H., and Woo K.S. The effects of Danshen (Salvia miltiorrhiza) on warfarin pharmacodynamics and pharmacokinetics of warfarin enantiomers in rats. J. Pharm. Pharmacol. 47 (1995) 402-406
2. Eagling V.A., Tjia J.F., and Back D.J. Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes. Br. J. Clin. Pharmacol. 45 (1998) 107-114
3. Easterbrook J., Fackett D., and Li A.P. A comparison of aroclor 1254-induced and uninduced rat liver microsomes to human liver microsomes in phenytoin O-deethylation, coumarin 7-hydroxylation, tolbutamide 4-hydroxylation, S-mephenytoin 4′-hydroxylation, chloroxazone 6-hydroxylation and testosterone 6β-hydroxylation. Chem.-Biol. Inter. 134 (2001) 243-249
4. He F., Bi H.C., Xie Z.Y., Zuo Z., Li J.K., Li X., Zhao L.Z., Chen X., and Huang M. Rapid determination of six metabolites from multiple cytochrome P450 probe substrates in human liver microsome by liquid chromatography/mass spectrometry: application to high throughput inhibition screening of terpenoids. Rapid Commun. Mass Spectrom. 21 (2007) 635-643
5. Holbrook A.M., Pereira J.A., Labiris R., McDonald H., Douketis J.D., Crowther M., and Wells P.S. Systematic overview of warfarin and its drug and food interactions. Arch. Intern. Med. 165 (2005) 1095-1106
6. Izzo A.A., Di Carlo G., Borrelli F., and Ernst E. Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction. Int. J. Cardiol. 98 (2005) 1-14
7. Kirchheiner J., and Brockmoller J. Clinical consequences of cytochrome P450 2C9 polymorphisms. Clin. Pharmacol. Ther. 77 (2005) 1-16
8. Kuo Y.H., Lin Y.L., Don M.J., Chen R.M., and Ueng Y.F. Induction of cytochrome P450 dependent monooxygenase by extracts of the medicinal herb Salvia miltiorrhiza. J. Pharm. Pharmacol. 58 (2006) 521-527
9. Lam F.F., Yeung J.H., Cheung J.H., and Or P.M. Pharmacological evidence for calcium channel inhibition by danshen (Salvia miltiorrhiza) on rat isolated femoral artery. J. Cardiovasc. Pharmacol. 47 (2006) 139-145
10. Lam F.F., Yeung J.H., Kwan Y.W., Chan K.M., and Or P.M. Salvianolic acid B, anaqueous component of danshen (Salvia miltiorrhiza), relaxes rat coronary artery by inhibition of calcium channels. Eur. J. Pharmacol. 553 (2006) 240-245
11. Li P., Wang G.J., Li J., Hao H.P., and Zheng C.N. Simultaneous determination of tanshinone IIA and its three hydroxylated metabolites by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 20 (2006) 815-822
12. Liu A.H., Lin Y.H., Yang M., Sun J.H., Guo H., and Guo D.A. High-performance liquid chromatographic determination of tanshinones in the roots of Salvia miltiorrhiza and related traditional Chinese medicinal preparations. J. Pharm. Pharm. Sci. 9 (2006) 1-9
13. Lo A.C., Chan K., Yeung J.H., and Woo K.S. The effects of Danshen (Salvia miltiorrhiza) on pharmacokinetics and pharmacodynamics of warfarin in rats. Eur. J. Drug Metab. Pharmacokinet. 17 (1992) 257-262
14. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 243 (1951) 1331-1332
15. Ma L., Zhang X., Guo H., and Gan Y. Determination of four water-soluble compounds in Salvia miltiorrhiza Bunge by high-performance liquid chromatography with a coulometric electrode array system. J. Chromatogr. B: Anal. Tech. Biomed. Life Sci. 833 (2006) 260-263
16. Raman P., Donkin S.S., and Spurlock M.E. Regulation of hepatic glucose metabolism by leptin in pig and rat primary hepatocyte cultures. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286 (2004) R206-R216
17. Rettie A.E., and Jones J.P. Clinical and toxicological relevance of CYP2C9: drug-drug interactions and pharmacogenetics. Ann. Rev. Pharmacol. Toxicol. 45 (2005) 477-494
18. Schenkman J.B., and Jansson I. Spectral analysis of cytochrome P450. In: Phillips I.R., and Stephard E.A. (Eds). Methods in Molecular Biology, Vol. 107: Cytochrome P450 Protocols (1998), Human Press Inc., Totowa 25-33
19. Seglen P.O. Preparation of isolated rat liver cells. Methods Cell Biol. 13 (1976) 29-83
20. Shi Z., He J., Yao T., Chang W., and Zhao M. Simultaneous determination of cryptotanshinone, tanshinone I and tanshinone IIA in traditional Chinese medicinal preparations containing Radix Salvia miltiorrhiza by HPLC. J. Pharm. Biomed. Anal. 37 (2005) 481-486
21. Song M., Hang T.J., Zhang Z.X., and Chen H.Y. Effects of coexisting diterpenoids tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat. Eur. J. Pharma. Sci. 32 (2007) 247-253
22. Sun J., Yang M., Han J., Wang B., Ma X., Xu M., Liu P., and Guo D. Profiling the metabolic difference of seven tanshinones using high-performance liquid chromatography/multi-stage mass spectrometry with data-dependent acquisition. Rapid Commun. Mass Spectrom. 21 (2007) 2211-2226
23. Ueng Y.F., Kuo Y.H., Peng H.C., Chen T.L., Jan W.C., Guengerich P.F., and Lin Y.L. Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome p4501A2. Xenobiotica 33 (2003) 603-613
24. Veronese M.E., Mcmanus M.E., Laupattarakasem P., Minors J.O., and Birkett D.J. Tolbutamide hydroxylation by human, rabbit and rat liver microsomes by purified forms of cytochrome P450. Drug Metab. Dispos. 18 (1990) 356-361
25. Wang X., Lee W.Y.W., Or P.M.Y., and Yeung J.H.K. Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates. Phytomedicine (2009) 10.1016/j.phymed.2009.03.004
26. Wang X., Morris-Natschke S.L., and Lee K.H. New developments in the chemistry and biology of the bioactive constituents of Tanshen. Med. Res. Rev. 27 (2007) 133-148
27. Wu W.W.P., and Yeung J.H.K. Inhibition of warfarin hydroxylation by major tanshinones of Danshen (Salvia miltiorrhiza) in the rat in vitro and in vivo. Phytomedicine (2009) 10.1016/j.phymed.2009.05.005
28. Yeung J.H.K., Chan S.L., and Or P.M.Y. Polysaccharide peptides from COV-1 strain of Coriolus versicolor inhibit tolbutamide 4-hydroxylation in the rat in vitro and in vivo. Food Chem. Toxicol. 44 (2006) 1414-1423
29. Yu C.M., Chan J.C., and Sanderson J.E. Chinese herbs and warfarin potentiation by 'Danshen'. J. Intern. Med. 241 (1997) 337-339
30. Zhang J.L., Cui M., He Y., Yu H.L., and Guo D.A. Chemical fingerprint and metabolic fingerprint analysis of Danshen injection by HPLC-UV and HPLC-MS methods. J. Pharma. Biomed. Anal. 36 (2005) 1029-1035
31. Zhou L., Zuo Z., and Chow M.S. Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J. Clin. Pharmacol. 45 (2005) 1345-1359