BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE)

Journal of Biological Chemistry

Volumn 286, Issue 43, 2011, Pages 37446-37457

  Kilger, Ellen ^a,b   Buehler, Anika ^a,b   Woelfing, Heidrun ^a,b   Kumar, Sathish ^d   Kaeser, Stephan A ^a,b   Nagarathinam, Amudha ^a,b,c   Walter, Jochen ^d   Jucker, Mathias ^a,b   Coomaraswamy, Janaky ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c Graduate School of Cellular and Molecular Neuroscience   (Germany)

^d UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; EXTRACELLULAR; IN-VIVO; INSULIN-DEGRADING ENZYMES; MOUSE MODELS; OVER-EXPRESSION; PEPTIDE SEQUENCES; PRECURSOR PROTEINS; PROTEOLYTIC CLEAVAGE; RECEPTOR PROTEINS; WILD TYPES;

AMINO ACIDS; ENZYMES; GLYCOPROTEINS; INSULIN; MAMMALS; METABOLISM; PEPTIDES; PHYSIOLOGY;

INTEGRODIFFERENTIAL EQUATIONS;

ADAN PRECURSOR PROTEIN; AMYLOID BETA PROTEIN; BRITISH PROTEIN PRECURSOR; GAMMA SECRETASE; INSULINASE; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBROSPINAL FLUID; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN SECRETION; REGULATORY MECHANISM;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; INSULYSIN; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; PROTEOLYSIS; SEQUENCE DELETION;

EID: 80054819853     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.288373     Document Type: Article

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