The extracellular domain of Bri2 (ITM2B) binds the ABri peptide (1-23) and amyloid β-peptide (Aβ1-40): Implications for Bri2 effects on processing of amyloid precursor protein and Aβ aggregation

Biochemical and Biophysical Research Communications

Volumn 393, Issue 3, 2010, Pages 356-361

  Peng, Siwei ^a   Fitzen, Michael ^b   Jörnvall, Hans ^b   Johansson, Jan ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Alzheimer's disease; APP; Bri2; Brichos domain; ITM2B; Protein interaction

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID PRECURSOR PROTEIN; INTEGRAL MEMBRANE PROTEIN 2B; MEMBRANE PROTEIN; PROTEIN BRI2; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS;

MUS MUSCULUS;

EID: 77949261577     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.12.122     Document Type: Article

References (28)

1. Rostagno A., Tomidokoro Y., Lashley T., Ng D., Plant G., Holton J., Frangione B., Revesz T., and Ghiso J. Chromosome 13 dementias. Cell Mol. Life Sci. 62 (2005) 1814-1825
2. Hatters D.M. Protein misfolding inside cells: the case of huntingtin and Huntington's disease. IUBMB Life 60 (2008) 724-728
3. Sanders C.R., and Nagy J.K. Misfolding of membrane proteins in health and disease: the lady or the tiger?. Curr. Opin. Struct. Biol. 10 (2000) 438-442
4. Ghiso J., Rostagno A., Tomidokoro Y., Lashley T., Bojsen-Moller M., Braendgaard H., Plant G., Holton J., Lal R., Revesz T., and Frangione B. Genetic alterations of the BRI2 gene: familial British and Danish dementias. Brain Pathol. 16 (2006) 71-79
5. Holton J.L., Lashley T., Ghiso J., Braendgaard H., Vidal R., Guerin C.J., Gibb G., Hanger D.P., Rostagno A., Anderton B.H., Strand C., Ayling H., Plant G., Frangione B., Revesz T., and Bojsen-Moller M. Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta. J. Neuropathol. Exp. Neurol. 61 (2002) 254-267
6. Tsachaki M., Ghiso J., and Efthimiopoulos S. BRI2 as a central protein involved in neurodegeneration. Biotechnol. J. 3 (2008) 1548-1554
7. Sisodia S.S., and Price D.L. Role of the beta-amyloid protein in Alzheimer's disease. Faseb J. 9 (1995) 366-370
8. Butterfield D.A., and Boyd-Kimball D. Amyloid beta-peptide(1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain. Brain Pathol. 14 (2004) 426-432
9. Jarrett J.T., Berger E.P., and Lansbury Jr. P.T. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 32 (1993) 4693-4697
10. Ling Y., Morgan K., and Kalsheker N. Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease. Int. J. Biochem. Cell Biol. 35 (2003) 1505-1535
11. Martin L., Fluhrer R., Reiss K., Kremmer E., Saftig P., and Haass C. Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. J. Biol. Chem. 283 (2008) 1644-1652
12. Gibson G., El-Agnaf O.M., Anwar Z., Sidera C., Isbister A., and Austen B.M. Structure and neurotoxicity of novel amyloids derived from the BRI gene. Biochem. Soc. Trans. 33 (2005) 1111-1112
13. Tomidokoro Y., Lashley T., Rostagno A., Neubert T.A., Bojsen-Moller M., Braendgaard H., Plant G., Holton J., Frangione B., Revesz T., and Ghiso J. Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND Aβ) in the absence of compact plaques. J. Biol. Chem. 280 (2005) 36883-36894
14. Fotinopoulou A., Tsachaki M., Vlavaki M., Poulopoulos A., Rostagno A., Frangione B., Ghiso J., and Efthimiopoulos S. BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Aβ) production. J. Biol. Chem. 280 (2005) 30768-30772
15. Kim J., Miller V.M., Levites Y., West K.J., Zwizinski C.W., Moore B.D., Troendle F.J., Bann M., Verbeeck C., Price R.W., Smithson L., Sonoda L., Wagg K., Rangachari V., Zou F., Younkin S.G., Graff-Radford N., Dickson D., Rosenberry T., and Golde T.E. BRI2 (ITM2b) inhibits Abeta deposition in vivo. J. Neurosci. 28 (2008) 6030-6036
16. Hedlund J., Johansson J., and Persson B. BRICHOS - a superfamily of multidomain proteins with diverse functions. BMC Res. Notes 2 (2009) 180
17. Sanchez-Pulido L., Devos D., and Valencia A. BRICHOS: a conserved domain in proteins associated with dementia, respiratory distress and cancer. Trends Biochem. Sci. 27 (2002) 329-332
18. Johansson J., Weaver T.E., and Tjernberg L.O. Proteolytic generation and aggregation of peptides from transmembrane regions: lung surfactant protein C and amyloid beta-peptide. Cell Mol. Life Sci. 61 (2004) 326-335
19. Johansson J. Molecular determinants for amyloid fibril formation: lessons from lung surfactant protein C. Swiss Med. Wkly 133 (2003) 275-282
20. Johansson H., Nordling K., Weaver T.E., and Johansson J. The Brichos domain-containing C-terminal part of pro-surfactant protein C binds to an unfolded poly-val transmembrane segment. J. Biol. Chem. 281 (2006) 21032-21039
21. Johansson H., Nerelius C., Nordling K., and Johansson J. Preventing amyloid formation by catching unfolded transmembrane segments. J. Mol. Biol. 389 (2009) 227-279
22. Nerelius C., Martin E., Peng S., Gustafsson M., Nordling K., Weaver T., and Johansson J. Mutations linked to interstitial lung disease can abrogate anti-amyloid function of prosurfactant protein C. Biochem. J. 416 (2008) 201-209
23. Fitzen M., Alvelius G., Nordling K., Jornvall H., Bergman T., and Johansson J. Peptide-binding specificity of the prosurfactant protein C Brichos domain analyzed by electrospray ionization mass spectrometry. Rapid. Commun. Mass Spectrom. 23 (2009) 3591-3598
24. Matsuda S., Giliberto L., Matsuda Y., McGowan E.M., and D'Adamio L. BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J. Neurosci. 28 (2008) 8668-8676
25. Matsuda S., Matsuda Y., and D'Adamio L. BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2. J. Biol. Chem. 284 (2009) 15815-15825
26. Westley B.R., Griffin S.M., and May F.E. Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C. Biochemistry 44 (2005) 7967-7975
27. Johansson H., Eriksson M., Nordling K., Presto J., and Johansson J. The Brichos domain of prosurfactant protein C can hold and fold a transmembrane segment. Protein Sci. 18 (2009) 1175-1182
28. S. Matsuda, Y. Matsuda, E.L. Snapp, L. D'Adamio, Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles, Neurobiol. Aging, 2009, 10.1016/j.neurobiolaging.2009.08.005.