Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia

Biochemical and Biophysical Research Communications

Volumn 332, Issue 3, 2005, Pages 808-816

  Morelli, Laura ^a   Llovera, Ramiro E ^a   Alonso, Leonardo G ^a   Frangione, Blas ^b   De Prat Gay, Gonzalo ^a   Ghiso, Jorge ^b   Castaño, Eduardo M ^a  

^a FUNDACIÓN INSTITUTO LELOIR   (Argentina)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amyloid; Cerebrovascular amyloidoses; Degradation; Hereditary dementia; Insulin degrading enzyme; Neurodegeneration

Indexed keywords

AMINO ACID DERIVATIVE; AMYLOID PROTEIN; INSULINASE; OLIGOMER; PROTEIN ABRI; PROTEIN ADAN; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; DEMENTIA; FAMILIAL DISEASE; IN VITRO STUDY; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; WILD TYPE;

AMINO ACID SEQUENCE; AMYLOID; ANIMALS; BINDING SITES; CYSTEINE; DEMENTIA; DENMARK; GENES, DOMINANT; GREAT BRITAIN; HUMANS; INSULYSIN; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MUTATION; PROTEIN STRUCTURE, QUATERNARY; RATS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 19744378269     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.05.020     Document Type: Article

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