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Analytical Chemistry

Volumn 81, Issue 20, 2009, Pages 8354-8364

Large-scale identification and quantification of covalent modifications in therapeutic proteins

(1) Zhang, Zhongqi a

a AMGEN INC (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOMATED ANALYSIS; CHROMATOGRAPHIC METHODS; CHROMATOGRAPHIC TECHNIQUES; COMPUTER ALGORITHM; COVALENT MODIFICATIONS; GLYCOFORMS; ION CHROMATOGRAM; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; MS/MS ANALYSIS; PEAK AREA; PEPTIDE IDENTIFICATION; PEPTIDE IONS; PROTEIN MODIFICATIONS; QUALITY ATTRIBUTES; RELATIVE QUANTIFICATION; SCALE METHOD; THERAPEUTIC PROTEIN; TRYPTIC DIGESTION; WINDOW FUNCTIONS;

ALGORITHMS; CHROMATOGRAPHIC ANALYSIS; IONS; MASS SPECTROMETERS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; PEPTIDES; WAVE INTERFERENCE;

AMINES;

IMMUNOGLOBULIN G2; MONOCLONAL ANTIBODY; PEPTIDE; PROTEIN;

ALGORITHM; ARTICLE; DIGESTION; EXPERIMENTAL STUDY; HUMAN; LIQUID CHROMATOGRAPHY; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN MODIFICATION; TANDEM MASS SPECTROMETRY;

ALGORITHMS; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, LIQUID; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; PROTEINS; PROTEOMICS; SOFTWARE; TANDEM MASS SPECTROMETRY;

EID: 70450078402 PISSN: 00032700 EISSN: None Source Type: Journal
DOI: 10.1021/ac901193n Document Type: Article

Times cited : (92)

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