Increased dopamine DRD4 receptor mRNA expression in lymphocytes of musicians and autistic individuals: Bridging the music-autism connection

Neuroendocrinology Letters

Volumn 31, Issue 1, 2010, Pages 122-125

  Emanuele, Enzo ^a   Boso, Marianna ^a   Cassola, Francesco ^b   Broglia, Davide ^a   Bonoldi, Ilaria ^a   Mancini, Lara ^a   Marini, Mara ^a   Politi, Pierluigi ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b IRCCS   (Italy)

Author keywords

Autistic spectrum disorder; Dopamine; Music; Reward

Indexed keywords

DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; MESSENGER RNA;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; AUTISM; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; GENE EXPRESSION; HUMAN; MUSICIAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; POST HOC ANALYSIS; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS;

EID: 77749346005     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Boso M, Emanuele E, Minazzi V, Abbamonte M, Politi P (2007). Effect of long-term interactive music therapy on behavior profile and musical skills in young adults with severe autism. J Altern Complement Med. 13: 709-712.
2. Broderick PA & Piercey MF (1998). Clozapine, haloperidol, and the D4 antagonist PNU-101387G: in vivo effects on mesocortical, mesolimbic, and nigrostriatal dopamine and serotonin release. J Neural Transm. 105: 749-767.
3. Czermak C, Lehofer M, Renger H, Wagner EM, Lemonis L, Rohrhofer A, et al (2004a). Dopamine receptor D3 mRNA expression in human lymphocytes is negatively correlated with the personality trait of persistence. J Neuroimmunol. 150: 145-149.
4. Czermak C, Lehofer M, Wagner EM, Prietl B, Lemonis L, Rohrhofer A, et al (2004b). Reduced dopamine D4 receptor mRNA expression in lymphocytes of long-term abstinent alcohol and heroin addicts. Addiction. 99: 251-257.
5. Emilien G, Maloteaux JM, Geurts M, Hoogenberg K, Cragg S (1999). Dopamine receptors - physiological understanding to therapeutic intervention potential. Pharmacol Ther. 84: 133-156.
6. Gardner EL & Ashby CR Jr (2000). Heterogeneity of the mesotelencephalic dopamine fibers: physiology and pharmacology. Neurosci Biobehav Rev. 24: 115-118.
7. Gobbi G & Pulvirenti L (2001). Long-term treatment with clozapine in an adult with autistic disorder accompanied by aggressive behaviour. J Psychiatry Neurosci. 26: 340-341.
8. Gold C, Wigram T, Elefant C (2006). Music therapy for autistic spectrum disorder. Cochrane Database Syst Rev. 19: CD004381.
9. Hoenicka J, Aragüés M, Ponce G, Rodríguez- Jiménez R, Jiménez-Arriero MA, Palomo T (2007). From dopaminergic genes to psychiatric disorders. Neurotox Res. 11: 61-72.
10. Ikemoto S (2007). Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain Res Rev. 56: 27-78.
11. Koob GF & Le Moal M (2008). Addiction and the brain antireward system. Annu Rev Psychol. 59: 29-53.
12. Livak KJ, Rogers J, Lichter JB (1995). Variability of dopamine D4 receptor (DRD4) gene sequence within and among nonhuman primate species. Proc Natl Acad Sci USA. 92: 427-431.
13. Menon V & Levitin DJ (2005). The rewards of music listening: response and physiological connectivity of the mesolimbic system. Neuroimage. 28: 175-184.
14. Schopler E, Reichler RJ, DeVellis RF, Daly K (1980). Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). J Autism Dev Disord. 10: 91-103.
15. Schultz W (2007). Behavioral dopamine signals. Trends Neurosci. 30: 203-210.
16. Treffert DA & Wallace GL (2002). Islands of genius. Artistic brilliance and a dazzling memory can sometimes accompany autism and other developmental disorders. Sci Am. 286: 76-85.
17. Wing L (1997). The autistic spectrum. Lancet. 350: 1761-1766.