Association between polymorphisms of DRD2 and DRD4 and opioid dependence: Evidence from the current studies

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 156, Issue 6, 2011, Pages 661-670

  Chen, Dingyan ^a   Liu, Fang ^a   Shang, Qinggang ^b   Song, Xiaoqin ^a   Miao, Xiaoping ^a   Wang, Zengzhen ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Shenzhen Center for Chronic Disease Control   (China)

Author keywords

Addiction; Dopamine receptor; Genetic polymorphism; Meta analysis; Susceptibility

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; OPIATE;

ALLELE; ARTICLE; CONTROLLED STUDY; EXON; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HOMOZYGOTE; HUMAN; META ANALYSIS; OPIATE ADDICTION; PRIORITY JOURNAL; RISK;

ALLELES; ANALGESICS, OPIOID; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; OPIOID-RELATED DISORDERS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4;

EID: 80051561427     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31208     Document Type: Article

References (54)

1. Arinami T, Gao M, Hamaguchi H, Toru M. 1997. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum Mol Genet 6: 577-582.
2. Asghari V, Sanyal S, Buchwaldt S, Paterson A, Jovanovic V, Van Tol HH. 1995. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 65: 1157-1165.
3. Barratt DT, Coller JK, Somogyi AA. 2006. Association between the DRD2 A1 allele and response to methadone and buprenorphine maintenance treatments. Am J Med Genet Part B 141B: 323-331.
4. Blum K, Braverman ER, Holder JM, Lubar JF, Monastra VJ, Miller D, Lubar JO, Chen TJ, Comings DE. 2000. Reward deficiency syndrome: A biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. J Psychoactive Drugs 32 (Suppl i-iv): 1-112.
5. Camarena B, Loyzaga C, Aguilar A, Weissbecker K, Nicolini H. 2007. Association study between the dopamine receptor D(4) gene and obsessive-compulsive disorder. Eur Neuropsychopharmacol 17: 406-409.
6. Cao L, Li T, Liu X. 2002. Association analysis of dopamine D4 receptor and heroin dependence. Chin J Nerv Ment Dis 28: 60.
7. Cao L, Li T, Liu X. 2003. Association study of heroin dependence and dopamine D2 receptor gene. Chin J Psychiatry 36: 31-33.
8. Chien CC, Lin CH, Chang YY, Lung FW. 2010. Association of VNTR polymorphisms in the MAOA promoter and DRD4 exon 3 with heroin dependence in male Chinese addicts. World J Biol Psychiatry 11: 409-416.
9. Choi KH, Whisler K, Graham DL, Self DW. 2006. Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement. Neuroscience 137: 373-383.
10. Cravchik A, Sibley DR, Gejman PV. 1996. Functional analysis of the human D2 dopamine receptor missense variants. J Biol Chem 271: 26013-26017.
11. Crettol S, Besson J, Croquette-Krokar M, Hammig R, Gothuey I, Monnat M, Deglon JJ, Preisig M, Eap CB. 2008. Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment. Prog Neuropsychopharmacol Biol Psychiatry 32: 1722-1727.
12. Demiralp T, Herrmann CS, Erdal ME, Ergenoglu T, Keskin YH, Ergen M, Beydagi H. 2007. DRD4 and DAT1 polymorphisms modulate human gamma band responses. Cereb Cortex 17: 1007-1019.
13. Doehring A, Hentig N, Graff J, Salamat S, Schmidt M, Geisslinger G, Harder S, Lotsch J. 2009. Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution. Pharmacogenet Genomics 19: 407-414.
14. Duaux E, Krebs MO, Loo H, Poirier MF. 2000. Genetic vulnerability to drug abuse. Eur Psychiatry 15: 109-114.
15. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D, Bennett ER, Nemanov L, Katz M, Belmaker RH. 1996. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet 12: 78-80.
16. Franke P, Nothen MM, Wang T, Knapp M, Lichtermann D, Neidt H, Sander T, Propping P, Maier W. 2000. DRD4 exon III VNTR polymorphism-susceptibility factor for heroin dependence? Results of a case-control and a family-based association approach. Mol Psychiatry 5: 101-104.
17. Hirvonen MM, Lumme V, Hirvonen J, Pesonen U, Nagren K, Vahlberg T, Scheinin H, Hietala J. 2009. C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo. Prog Neuropsychopharmacol Biol Psychiatry 33: 630-636.
18. Ho AM, Tang NL, Cheung BK, Stadlin A. 2008. Dopamine receptor D4 gene -521C/T polymorphism is associated with opioid dependence through cold-pain responses. Ann N Y Acad Sci 1139: 20-26.
19. Hou QF, Li SB. 2009. Potential association of DRD2 and DAT1 genetic variation with heroin dependence. Neurosci Lett 464: 127-130.
20. Jonsson EG, Nothen MM, Grunhage F, Farde L, Nakashima Y, Propping P, Sedvall GC. 1999. Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Mol Psychiatry 4: 290-296.
21. Knapp CM, Lee K, Foye M, Ciraulo DA, Kornetsky C. 2001. Additive effects of intra-accumbens infusion of the cAMP-specific phosphodiesterase inhibitor, rolipram and cocaine on brain stimulation reward. Life Sci 69: 1673-1682.
22. Kotler M, Cohen H, Segman R, Gritsenko I, Nemanov L, Lerer B, Kramer I, Zer-Zion M, Kletz I, Ebstein RP. 1997. Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects. Mol Psychiatry 2: 251-254.
23. LaHoste GJ, Swanson JM, Wigal SB, Glabe C, Wigal T, King N, Kennedy JL. 1996. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol Psychiatry 1: 121-124.
24. Lawford BR, Young RM, Noble EP, Sargent J, Rowell J, Shadforth S, Zhang X, Ritchie T. 2000. The D(2) dopamine receptor A(1) allele and opioid dependence: Association with heroin use and response to methadone treatment. Am J Med Genet 96: 592-598.
25. Li T, Xu K, Deng H, Cai G, Liu J, Liu X, Wang R, Xiang X, Zhao J, Murray RM, et al. 1997. Association analysis of the dopamine D4 gene exon III VNTR and heroin abuse in Chinese subjects. Mol Psychiatry 2: 413-416.
26. Li T, Zhu ZH, Liu X, Hu X, Zhao J, Sham PC, Collier DA. 2000. Association analysis of polymorphisms in the DRD4 gene and heroin abuse in Chinese subjects. Am J Med Genet 96: 616-621.
27. Li T, Liu X, Zhao J, Hu X, Ball DM, Loh el W, Sham PC, Collier DA. 2002. Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects. Am J Med Genet Part B 114B: 329-335.
28. Li Y, Shao C, Zhang D, Zhao M, Lin L, Yan P, Xie Y, Jiang K, Jin L. 2006. The effect of dopamine D2, D5 receptor and transporter (SLC6A3) polymorphisms on the cue-elicited heroin craving in Chinese. Am J Med Genet Part B 141B: 269-273.
29. Lopez Leon S, Croes EA, Sayed-Tabatabaei FA, Claes S, Van Broeckhoven C, van Duijn CM. 2005. The dopamine D4 receptor gene 48-base-pair-repeat polymorphism and mood disorders: A meta-analysis. Biol Psychiatry 57: 999-1003.
30. Lynch WJ, Taylor JR. 2005. Persistent changes in motivation to self-administer cocaine following modulation of cyclic AMP-dependent protein kinase A (PKA) activity in the nucleus accumbens. Eur J Neurosci 22: 1214-1220.
31. Marcos M, Gomez-Munuera M, Pastor I, Gonzalez-Sarmiento R, Laso FJ. 2009. Tumor necrosis factor polymorphisms and alcoholic liver disease: A HuGE review and meta-analysis. Am J Epidemiol 170: 948-956.
32. Munafo MR, Timpson NJ, David SP, Ebrahim S, Lawlor DA. 2009. Association of the DRD2 gene Taq1A polymorphism and smoking behavior: A meta-analysis and new data. Nicotine Tob Res 11: 64-76.
33. Noble EP. 2000. Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: A review. Eur Psychiatry 15: 79-89.
34. Noble EP, Blum K, Ritchie T, Montgomery A, Sheridan PJ. 1991. Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 48: 648-654.
35. Noble EP, Gottschalk LA, Fallon JH, Ritchie TL, Wu JC. 1997. D2 dopamine receptor polymorphism and brain regional glucose metabolism. Am J Med Genet 74: 162-166.
36. Parsian A, Cloninger CR, Zhang ZH. 2000. Functional variant in the DRD2 receptor promoter region and subtypes of alcoholism. Am J Med Genet Part B 96B: 407-411.
37. Peng D, Wang X, Wang G, Peng Y. 2002. Association between a DRD2 marker (TaqIA) and heroin dependence. Chin Ment Health J 16: 618-620.
38. Perez de Castro I, Ibanez A, Torres P, Saiz-Ruiz J, Fernandez-Piqueras J. 1997. Genetic association study between pathological gambling and a functional DNA polymorphism at the D4 receptor gene. Pharmacogenetics 7: 345-348.
39. Perez de los Cobos J, Baiget M, Trujols J, Sinol N, Volpini V, Banuls E, Calafell F, Luquero E, del Rio E, Alvarez E. 2007. Allelic and genotypic associations of DRD2 TaqI A polymorphism with heroin dependence in Spanish subjects: A case control study. Behav Brain Funct 3: 25.
40. Persico AM, Bird G, Gabbay FH, Uhl GR. 1996. D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: Enhanced frequencies in psychostimulant-preferring polysubstance abusers. Biol Psychiatry 40: 776-784.
41. Pierce RC, Kumaresan V. 2006. The mesolimbic dopamine system: The final common pathway for the reinforcing effect of drugs of abuse? Neurosci Biobehav Rev 30: 215-238.
42. Rubinstein M, Phillips TJ, Bunzow JR, Falzone TL, Dziewczapolski G, Zhang G, Fang Y, Larson JL, McDougall JA, Chester JA, et al. 1997. Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 90: 991-1001.
43. Schoots O, Van Tol HH. 2003. The human dopamine D4 receptor repeat sequences modulate expression. Pharmacogenomics J 3: 343-348.
44. Shahmoradgoli Najafabadi M, Ohadi M, Joghataie MT, Valaie F, Riazalhosseini Y, Mostafavi H, Mohammadbeigi F, Najmabadi H. 2005. Association between the DRD2 A1 allele and opium addiction in the Iranian population. Am J Med Genet Part B 134B: 39-41.
45. Shao C, Jiang K, Li Y, Zhao M, Song L, Xu Y, Zhang D, Wang Q, Zhu M, Zhou W. 2005a. Relationship between DRD4 receptor gene polymorphism and heroin dependence and cue-elicited heroin craving. Shanghai Arch Psychiatry 17: 193-196.
46. Shao C, Li Y, Jiang K, Zhao M, Lin L, Song L, Xu Y, Zhu M, Wang Q, Zhou W. 2005b. Relationship between DRD2 receptor gene -141C Ins/Del polymorphism and heroin dependence. Chin J Behav Med Sci 14: 885-886.
47. Simpson J, Vetuz G, Wilson M, Brookes KJ, Kent L. 2010. The DRD4 receptor exon 3 VNTR and 5' SNP variants and mRNA expression in human post-mortem brain tissue. Am J Med Genet Part B 153B: 1228-1233.
48. Smith L, Watson M, Gates S, Ball D, Foxcroft D. 2008. Meta-analysis of the association of the Taq1A polymorphism with the risk of alcohol dependency: A HuGE gene-disease association review. Am J Epidemiol 167: 125-138.
49. UNODC. 2003. Global Illicit Drug Trends, 2003.
50. Xu K, Lichtermann D, Lipsky RH, Franke P, Liu X, Hu Y, Cao L, Schwab SG, Wildenauer DB, Bau CH, et al. 2004. Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations. Arch Gen Psychiatry 61: 597-606.
51. Xu Z, Chen X, Chen L, Hu H, Du Z, Wang F, Li X, Wang C. 2005. Study of DRD2 gene to heroin abuse in a large Chinese example. J Law Med 12: 209-210.
52. Xu Z, XU D, Zhang J, Lin Y, Chen X, Chen L. 2006. Correlated study of heroin dependence and DRD2 receptor gene Taq I A Polymorphism. J Kunming Med Coll 27: 41-44.
53. Zhao M, Yang D, Hao W, Zhang X, Zhang Y, Li L, Wang X. 2001. Associations between heroin dependence and dopamine D4 and 5-HT2C receptor gene. Chin J Behav Med Sci 10: 412-413, 415.
54. Zheng H, Wang Z, Shi X, Wang Z. 2009. XRCC1 polymorphisms and lung cancer risk in Chinese populations: A meta-analysis. Lung Cancer 65: 268-273.