Interaction Effect of D4 Dopamine Receptor Gene and Serotonin Transporter Promoter Polymorphism on the Cortisol Stress Response

Behavioral Neuroscience

Volumn 123, Issue 6, 2009, Pages 1288-1295

  Armbruster, D ^a   Mueller, A ^a   Moser, D A ^b   Lesch, K P ^c   Brocke, B ^a   Kirschbaum, C ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF TRIER   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

5 HTTLPR; cortisol; DRD4; HPA; stress

Indexed keywords

DOPAMINE 4 RECEPTOR; HYDROCORTISONE; SEROTONIN TRANSPORTER;

ADULT; ALLELE; ARTICLE; BEHAVIOR GENETICS; FEAR; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENETIC POLYMORPHISM; GENOTYPE; HOMOZYGOTE; HORMONE RESPONSE; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; MENTAL STRESS; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; PROMOTER REGION; SALIVA LEVEL; STIMULUS RESPONSE; TRIER SOCIAL STRESS TEST;

ADULT; ALLELES; ANALYSIS OF VARIANCE; DOPAMINE; EXONS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PITUITARY-ADRENAL SYSTEM; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; QUESTIONNAIRES; RECEPTORS, DOPAMINE D4; SALIVA; SELF ASSESSMENT (PSYCHOLOGY); SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS, PSYCHOLOGICAL;

EID: 72249102004     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/a0017615     Document Type: Article

References (66)

1. Achenbach T.M. Manual for the Child Behavior Checklist/4-18 and 1991 profile (1991), University of Vermont, Department of Psychiatry, Burlington
2. Asghari V., Sanyal S., Buchwaldt S., Paterson A., Jovanovic V., and Van Tol H.H. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. Journal of Neurochemistry 65 (1995) 1157-1165
3. Auerbach J., Faroy M., Ebstein R., Kahana M., and Levine J. The association of the dopamine D4 receptor gene (DRD4) and the serotonin transporter promoter gene (5-HTTLPR) with temperament in 12-month-old infants. Journal of Child Psychology and Psychiatry, and Allied Disciplines 42 (2001) 777-783
4. Auerbach J., Geller V., Lezer S., Shinwell E., Belmaker R.H., Levine J., and Ebstein R. Dopamine D4 receptor (DRD4) and serotonin transporter promoter (5-HTTLPR) polymorphisms in the determination of temperament in 2-month-old infants. Molecular Psychiatry 4 (1999) 369-373
5. Azmita E.C., and Gannon P.J. The primate serotonergic system: A review of human and animal studies and a report on Macaca fascicularis. Advances in Neurology 43 (1986) 407-468
6. Barr C.S., Newman T.K., Schwandt M., Shannon C., Dvoskin R.L., Lindell S.G., et al. Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proceedings of the National Academy of Sciences, USA 101 (2004) 12358-12363
7. Barr C.S., Newman T.K., Shannon C., Parker C., Dvoskin R.L., Becker M.L., et al. Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biological Psychiatry 55 (2004) 733-738
8. Beck J.G., Carmin C.N., and Henninger N.J. The utility of the Fear Survey Schedule-III: An extended replication. Journal of Anxiety Disorders 12 (1998) 177-182
9. Calogero A.E., Bagdy G., Moncada M.L., and D'Agata R. Effect of selective serotonin agonists on basal, corticotrophin-releasing hormone- and vasopressin-induced ACTH release in vitro from rat pituitary cells. Journal of Endocrinology 136 (1993) 381-387
10. Canli T., Omura K., Haas B.W., Fallgatter A., Constable R.T., and Lesch K.P. Beyond affect: A role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proceedings of the National Academy of Sciences, USA 102 (2005) 12224-12229
11. Canli T., Qiu M., Omura K., Congdon E., Haas B.W., Amin Z., and Lesch K.P. Neural correlates of epigenesis. Proceedings of the National Academy of Sciences, USA 103 (2006) 16033-16038
12. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., and Poulton R. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
13. Cohen S., Kamarck T., and Mermelstein R. A global measure of perceived stress. Journal of Health and Social Behavior 24 (1983) 385-396
14. Dickerson S.S., and Kemeny M.E. Acute stressors and cortisol responses: A theoretical integration and synthesis of laboratory research. Psychological Bulletin 130 (2004) 355-391
15. Ding Y.C., Chi H.C., Grady D.L., Morishima A., Kidd J.R., Kidd K.K., and Moyzis R.K. Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proceedings of the National Academy of Sciences, USA 99 (2002) 309-314
16. Ebstein R. The molecular genetic architecture of human personality: Beyond self-report questionnaires. Molecular Psychiatry 11 (2006) 427-445
17. Ebstein R., Levine J., Geller V., Auerbach J., Gritsenko I., and Belmaker R.H. Dopamine D4 receptor and serotonin transporter promoter in the determination of neonatal temperament. Molecular Psychiatry 3 (1998) 238-246
18. Ebstein R., Novick O., Umansky R., Priel B., Osher Y., Blaine D., and Belmaker R.H. Dopamine D4 receptor (DRD4) exon III polymorphism associated with the human personality trait of novelty seeking. Nature Genetics 12 (1996) 78-80
19. Faraone S.V., Perlis R.H., Doyle A.E., Smoller J.W., Goralnick J.J., Holmgren M.A., and Sklar P. Molecular genetics of attention-deficit/hyperactivity disorder. Biological Psychiatry 57 (2005) 1313-1323
20. Fuller R.W. The involvement of serotonin in regulation of pituitary-adrenocortical function. Frontiers in Neuroendocrinology 13 (1992) 250-270
21. Fuller R.W. Serotonin receptors involved in regulation of pituitary-adrenocortical function in rats. Behavioural Brain Research 73 (1996) 215-219
22. Gaab J., Rohleder N., Nater U.M., and Ehlert U. Psychological determinants of the cortisol stress response: The role of anticipatory cognitive appraisal. Psychoneuroendocrinology 30 (2005) 599-610
23. Gelernter J., Cubells J.F., Kidd J.R., Pakstis A.J., and Kidd K.K. Population studies of polymorphisms of the serotonin transporter protein gene. American Journal of Medical Genetics 88 (1999) 61-66
24. Glatt C.E., and Freimer N.B. Association analysis of candidate genes for neuropsychiatric disease: The perpetual campaign. Trends in Genetics 18 (2002) 307-312
25. Goldman D., Oroszi G., and Ducci F. The genetics of addictions: Uncovering the genes. Nature Reviews Genetics 6 (2005) 521-532
26. Gotlib I.H., Joormann J., Minor K.L., and Hallmayer J. HPA axis reactivity: A mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biological Psychiatry 63 (2008) 847-851
27. Hariri A.R., Mattay V.S., Tessitore A., Kolachana B., Fera F., Goldman D., and Weinberger D.R. Serotonin transporter genetic variation and the response of the human amygdala. Science 297 (2002) 400-403
28. Hariri A.R., and Weinberger D.R. Functional neuroimaging of genetic variation in serotonergic neurotransmission. Genes, Brain, and Behavior 2 (2003) 341-349
29. Heils A., Teufel A., Petri S., Stober G., Riederer P., Bengel D., and Lesch K.P. Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry 66 (1996) 2621-2624
30. Heinz A., Braus D.F., Smolka M.N., Wrase J., Puls I., Hermann D., and Büchel C. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience 8 (2005) 20-21
31. Heinz A., Smolka M.N., Braus D.F., Wrase J., Beck A., Flor H., and Weinberger D.R. Serotonin transporter genotype (5-HTTLPR): Effects of neutral and undefined conditions on amygdala activation. Biological Psychiatry 61 (2007) 1011-1014
32. Herman J.P., Figueiredo H., Mueller N.K., Ulrich-Lai Y., Ostrander M.M., Choi D.C., and Cullinan W.E. Central mechanisms of stress integration: Hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Frontiers in Neuroendocrinology 24 (2003) 151-180
33. Hu X., Oroszi G., Chun J., Smith T.L., Goldman D., and Schuckit M.A. An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcoholism, Clinical and Experimental Research 29 (2005) 8-16
34. Hu X.Z., Lipsky R.H., Zhu G., Akhtar L.A., Taubman J., Greenberg B.D., and Goldman D. Serotonin tranporter gain-of-function genotypes are linked to obsessive compulsive disorder. American Journal of Human Genetics 78 (2006) 815-826
35. Jacobs B.L., and Azmitia E.C. Structure and function of the brain serotonin system. Physiological Reviews 72 (1992) 165-229
36. Jankord R., and Herman J.P. Limbic regulation of hypothalamo-pituitary-adrenocortical function during acute and chronic stress. Annals of the New York Academy of Sciences 1148 (2008) 64-73
37. Kang J.I., Namkoong K., and Kim S.J. The association of 5-HTTLPR and DRD4 VNTR polymorphisms with affective temperamental traits in healthy volunteers. Journal of Affective Disorders 109 (2008) 157-163
38. Kendler K.S., Kuhn J.W., Vittum J., Prescott C.A., and Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: A replication. Archives of General Psychiatry 62 (2005) 529-535
39. Kendler K.S., Neale M.C., Kessler R.C., Heath A.C., and Eaves L.J. The genetic epidemiology of phobias in women: The interrelationship of agoraphobia, social phobia, situational phobia, and simple phobia. Archives of General Psychiatry 49 (1992) 273-281
40. Kirschbaum C., Pirke K.M., and Hellhammer D.H. The "Trier Social Stress Test"-A tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 28 (1993) 76-81
41. Kraft J.B., Slager S.L., McGrath P.J., and Hamilton S.P. Sequence analysis of the serotonin transporter and associations with antidepressant response. Biological Psychiatry 58 (2005) 374-381
42. Kudielka B.M., Hellhammer D.H., and Kirschbaum C. Ten years of research with the Trier Social Stress Test-Revisited. In: Harmon-Jones E., and Winkielman P. (Eds). Social neuroscience: Integrating biological and psychological explanations of social behavior (2007), Guilford Press, New York, NY 56-83
43. Lacey J.I., and Lacey B.C. Verification and extension of the principle of autonomic response-stereotypy. American Journal of Psychology 71 (1958) 50-73
44. LeDoux J.E. Cognitive-emotional interactions: Listen to the brain. In: Lane R.D., and Nadel L. (Eds). Cognitive neuroscience of emotion (2000), Oxford University Press, New York, NY 129-155
45. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., and Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1531
46. Munafò M.R., Clark T., and Flint J. Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis. Molecular Psychiatry 10 (2005) 415-419
47. Nakamura M., Ueno S., Sano A., and Tanabe H. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Molecular Psychiatry 5 (2000) 32-38
48. Oades R.D., and Müller B. The development of conditioned blocking and monoamine metabolism in children with attention-deficit-hyperactivity disorder or complex tics and healthy controls: An exploratory analysis. Behavioural Brain Research 88 (1997) 95-102
49. Oak J.N., Oldenhof J., and Van Tol H.H. The dopamine D(4) receptor: One decade of research. European Journal of Pharmacology 405 (2000) 303-327
50. O'Hara R., Schroder C.M., Mahadevan R., Schatzberg A.F., Lindley S., Fox S., et al. Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: Association and interaction with cortisol. Molecular Psychiatry 12 (2007) 544-555
51. Pezawas L., Meyer-Lindenberg A., Drabant E.M., Verchinski B.A., Munoz K.E., Kolachana B.S., and Weinberger D.R. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nature Neuroscience 8 (2005) 828-834
52. Phelps E.A., and LeDoux J.E. Contributions of the amygdala to emotion processing: From animal models to human behavior. Neuron 48 (2005) 175-187
53. Porter R.J., Gallagher P., Watson S., and Young A.H. Corticosteroid-serotonin interactions in depression: A review of the human evidence. Psychopharmacology (Berl) 173 (2004) 1-17
54. Reist C., Ozdemir V., Wang E., Hashemzadeh M., Mee S., and Moyzis R. Novelty seeking and the dopamine D4 receptor gene (DRD4) revisited in Asians: Haplotype characterization and relevance of the 2-repeat allele. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 144 (2007) 453-457
55. Schinka J.A., Busch R.M., and Robichaux-Keene N. A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Molecular Psychiatry 9 (2004) 197-202
56. Schmidt L.A., Fox N.A., and Hamer D.H. Evidence for a gene-gene interaction in predicting children's behavior problems: Association of serotonin transporter short and dopamine receptor D4 long genotypes with internalizing and externalizing behaviors in typically developing 7-year-olds. Development and Psychopathology 19 (2007) 1105-1116
57. Schulz P., Schlotz W., and Becker P. Trierer Inventar zum chronischen Stress (2004), Hogrefe Verlag, Göttingen, Germany
58. Sen S., Burmeister M., and Ghosh D. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 127 (2004) 85-89
59. Spielberger C.D., Gorsuch R.L., and Lushene R.E. Manual for the State-Trait Anxiety Inventory (Self-Evaluation Questionnaire) (1970), Consulting Psychologists Press, Palo Alto, CA
60. Steyer R., Schwenkmezger P., Notz P., and Eid M. Der Mehrdimensionale Befindlichkeitsfragebogen (MDBF): Handanweisung (1997), Hogrefe, Göttingen, Germany
61. Sundet J.M., Skre I., Okkenhaug J.J., and Tambs K. Genetic and environmental causes of the interrelationships between self-reported fears: A study of a non-clinical sample of Norwegian identical twins and their families. Scandinavian Journal of Psychology 44 (2003) 97-106
62. Wang E., Ding Y.C., Flodman P., Kidd J.R., Kidd K.K., Grady D.L., and Moyzis R.K. The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. American Journal of Human Genetics 74 (2004) 931-944
63. Weidenfeld J., Newman M.E., Itzik A., Gur E., and Feldman S. The amygdala regulates the pituitary-adrenocortical response and release of hypothalamic serotonin following electrical stimulation of the dorsal raphe nucleus in the rat. Neuroendocrinology 76 (2002) 63-69
64. Wendland J.R., Martin B.J., Kruse M.R., Lesch K.P., and Murphy D.L. Simultaneous genotyping of four functional loci of human SLC6A4, with reappraisal of 5-HTTLPR and rs25531. Molecular Psychiatry 11 (2006) 224-226
65. White T.L., and Depue R.A. Differential association of traits of fear and anxiety with norepinephrine- and dark-induced pupil reactivity. Journal of Personality and Social Psychology 77 (1999) 863-877
66. Zhao J.H. 2LD, GENECOUNTING and HAP: Computer programs for linkage disequilibrium analysis. Bioinformatics 20 (2004) 1325-1326