The molecular genetics of executive function: Role of monoamine system genes

Biological Psychiatry

Volumn 69, Issue 12, 2011, Pages

  Barnes, Jessica J M ^a   Dean, Angela J ^a   Nandam, L Sanjay ^a   O'Connell, Redmond G ^b   Bellgrove, Mark A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Attention; dopamine; executive function; genetics; noradrenaline; serotonin

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; DOPAMINE; DOPAMINE 4 RECEPTOR; DOPAMINE TRANSPORTER; DOSULEPIN; ESCITALOPRAM; FLUOXETINE; METHYLPHENIDATE; MONOAMINE; NORADRENALIN; PLACEBO; SEROTONIN;

ATTENTION; ATTENTION DEFICIT DISORDER; DOPAMINERGIC TRANSMISSION; DRUG MECHANISM; ERROR; ERROR PROCESSING; EXECUTIVE FUNCTION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; INFORMATION PROCESSING; INHIBITION (PSYCHOLOGY); MOLECULAR GENETICS; NEUROSCIENCE; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; RESPONSE INHIBITION; REVIEW; SEROTONINERGIC SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; SUSTAINED ATTENTION; TASK PERFORMANCE;

ANIMALS; ATTENTION; BIOGENIC MONOAMINES; EXECUTIVE FUNCTION; HUMANS; INHIBITION (PSYCHOLOGY); MODELS, BIOLOGICAL; POLYMORPHISM, GENETIC; PSYCHOMOTOR PERFORMANCE; PSYCHOTROPIC DRUGS;

EID: 79958173109     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.12.040     Document Type: Review

References (186)

1. A. Miyake, N.P. Friedman, M.J. Emerson, A.H. Witzki, A. Howerter, and T.D. Wager The unity and diversity of executive functions and their contributions to complex "frontal lobe" tasks: A latent variable analysis Cogn Psychol 41 2000 49 100
2. A.R. Aron, P.C. Fletcher, E.T. Bullmore, B.J. Sahakian, and T.W. Robbins Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans Nat Neurosci 6 2003 115 116 (Pubitemid 36182778)
3. R.A. Barkley Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD Psychol Bull 121 1997 65 94 (Pubitemid 127705285)
4. R.G. O'Connell, M.A. Bellgrove, P.M. Dockree, A. Lau, R. Hester, and H. Garavan The neural correlates of deficient error awareness in attention-deficit hyperactivity disorder (ADHD) Neuropsychologia 47 2009 1149 1159
5. M.A. Bellgrove, C.D. Chambers, A. Vance, N. Hall, M. Karamitsios, and J.L. Bradshaw Lateralized deficit of response inhibition in early-onset schizophrenia Psychol Med 36 2006 495 505 (Pubitemid 43381002)
6. N. Friedman, A. Miyake, S. Young, J. Defries, R. Corley, and J. Hewitt Individual differences in executive functions are almost entirely genetic in origin J Exp Psychol Gen 137 2008 201 225
7. G. Winterer, and D. Goldman Genetics of human prefrontal function Brain Res Brain Res Rev 43 2003 134 163 (Pubitemid 37130084)
8. R. Parasuraman, P.M. Greenwood, R. Kumar, and J. Fossella Beyond heritability: Neurotransmitter genes differentially modulate visuospatial attention and working memory Psychol Sci 16 2005 200 207 (Pubitemid 40451209)
9. M.A. Bellgrove, Z. Hawi, M. Gill, and I.H. Robertson The cognitive genetics of attention deficit hyperactivity disorder (ADHD): Sustained attention as a candidate phenotype Cortex 42 2006 838 845 (Pubitemid 46768738)
10. T.E. Goldberg, and D.R. Weinberger Genes and the parsing of cognitive processes Trends Cogn Sci 8 2004 325 335 (Pubitemid 38887449)
11. M.A. Bellgrove, and J.B. Mattingley Molecular genetics of attention Ann N Y Acad Sci 1129 2008 200 212 (Pubitemid 351990283)
12. A. Papassotiropoulos, D.A. Stephan, M.J. Huentelman, F.J. Hoerndli, D.W. Craig, and J.V. Pearson Common Kibra alleles are associated with human memory performance Science 314 2006 475 478 (Pubitemid 44628970)
13. A.C. Need, D.K. Attix, J.M. McEvoy, E.T. Cirulli, K.L. Linney, and P. Hunt A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB Hum Mol Genet 18 2009 4650 4661
14. A. Abbott Psychiatric genetics: The brains of the family Nature 454 2008 154 157 (Pubitemid 351969871)
15. I.H. Robertson, T. Manly, J. Andrade, B.T. Baddeley, and J. Yiend "Oops!": Performance correlates of everyday attentional failures in traumatic brain injured and normal subjects Neuropsychologia 35 1997 747 758 (Pubitemid 27263222)
16. R.G. O'Connell, P.M. Dockree, I.H. Robertson, M.A. Bellgrove, J.J. Foxe, and S.P. Kelly Uncovering the neural signature of lapsing attention: Electrophysiological signals predict errors up to 20 s before they occur J Neurosci 29 2009 8604 8611
17. D.H. Weissman, K.C. Roberts, K.M. Visscher, and M.G. Woldorff The neural bases of momentary lapses in attention Nat Neurosci 9 2006 971 978 (Pubitemid 43980513)
18. T. Manly, A.M. Owen, L. McAvinue, A. Datta, G.H. Lewis, and S.K. Scott Enhancing the sensitivity of a sustained attention task to frontal damage: Convergent clinical and functional imaging evidence Neurocase 9 2003 340 349 (Pubitemid 36949462)
19. J.V. Pardo, P.T. Fox, and M.E. Raichle Localization of a human system for sustained attention by positron emission tomography Nature 349 1991 61 64 (Pubitemid 21912013)
20. W. Sturm, A. de Simone, B.J. Krause, K. Specht, V. Hesselmann, and I. Radermacher Functional anatomy of intrinsic alertness: Evidence for a fronto-parietal-thalamic-brainstem network in the right hemisphere Neuropsychologia 37 1999 797 805 (Pubitemid 29245978)
21. J.T. Coull, C. Buchel, K.J. Friston, and C.D. Frith Noradrenergically mediated plasticity in a human attentional neuronal network Neuroimage 10 1999 705 715 (Pubitemid 30026764)
22. W. Sturm, and K. Willmes On the functional neuroanatomy of intrinsic and phasic alertness Neuroimage 14 2001 S76 S84
23. W. Sturm, F. Longoni, B. Fimm, T. Dietrich, S. Weis, and S. Kemna Network for auditory intrinsic alertness: A PET study Neuropsychologia 42 2004 563 568 (Pubitemid 38064280)
24. Y.D. Van der Werf, M.P. Witter, and H.J. Groenewegen The intralaminar and midline nuclei of the thalamus Anatomical and functional evidence for participation in processes of arousal and awareness Brain Res Brain Res Rev 39 2002 107 140 (Pubitemid 35341095)
25. A. Mazaheri, I.L. Nieuwenhuis, H. van Dijk, and O. Jensen Prestimulus alpha and mu activity predicts failure to inhibit motor responses Hum Brain Mapp 30 2009 1791 1800
26. R.T. Marrocco, E.A. Witte, and M.C. Davidson Arousal systems Curr Opin Neurobiol 4 1994 166 170 (Pubitemid 24126277)
27. F. Javoy-Agid, B. Scatton, M. Ruberg, R. L'Heureux, P. Cervera, and R. Raisman Distribution of monoaminergic, cholinergic, and GABAergic markers in the human cerebral cortex Neuroscience 29 1989 251 259 (Pubitemid 19113419)
28. T. Sagvolden The alpha-2A adrenoceptor agonist guanfacine improves sustained attention and reduces overactivity and impulsiveness in an animal model of attention-deficit/hyperactivity disorder (ADHD) Behav Brain Funct 2 2006 41
29. J.A. Milstein, O. Lehmann, D.E. Theobald, J.W. Dalley, and T.W. Robbins Selective depletion of cortical noradrenaline by anti-dopamine beta-hydroxylase-saporin impairs attentional function and enhances the effects of guanfacine in the rat Psychopharmacology (Berl) 190 2007 51 63 (Pubitemid 44885343)
30. T. Sagvolden, and T. Xu l-amphetamine improves poor sustained attention while d-amphetamine reduces overactivity and impulsiveness as well as improves sustained attention in an animal model of attention-deficit/hyperactivity disorder (ADHD) Behav Brain Funct 4 2008 3
31. C. Matrenza, J.M. Hughes, A.H. Kemp, K.A. Wesnes, B.J. Harrison, and P.J. Nathan Simultaneous depletion of serotonin and catecholamines impairs sustained attention in healthy female subjects without affecting learning and memory Psychopharmacologie 18 2004 21 31 (Pubitemid 38623090)
32. A. Smith, and D. Nutt Noradrenaline and attention lapses Nature 380 1996 291
33. S.S. Gau, and C.Y. Shang Improvement of executive functions in boys with attention deficit hyperactivity disorder: An open-label follow-up study with once-daily atomoxetine Int J Neuropsychopharmacol 13 2010 243 256
34. C.W. Berridge, D.M. Devilbiss, M.E. Andrzejewski, A.F. Arnsten, A.E. Kelley, and B. Schmeichel Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function Biol Psychiatry 60 2006 1111 1120 (Pubitemid 44647216)
35. Berridge CW, Devilbiss DM (in press): Psychostimulants as Cognitive Enhancers: The prefrontal cortex, catecholamines, and attention-deficit/ hyperactivity disorder. Biol Psychiatry.
36. J. Hood, G. Baird, P. Rankin, and E. Isaacs Immediate effects of methylphenidate on cognitive attention skills of children with attention-deficit-hyperactivity disorder Dev Med Child Neurol 47 2005 408 414 (Pubitemid 40740500)
37. D. Turner, A. Blackwell, J. Dowson, and B. Sahakian Neurocognitive effects of methylphenidate in adult attention-deficit/hyperactivity disorder Psychopharmacology 178 2005 286 295 (Pubitemid 40379223)
38. S. Granon, F. Passetti, K.L. Thomas, J.W. Dalley, B.J. Everitt, and T.W. Robbins Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex J Neurosci 20 2000 1208 1215 (Pubitemid 30220477)
39. H. Saeedi, G. Remington, and B.K. Christensen Impact of haloperidol, a dopamine D2 antagonist, on cognition and mood Schizophr Res 85 2006 222 231 (Pubitemid 43947541)
40. J.G. Ramaekers, N.D. Muntjewerff, and J.F. O'Hanlon A comparative study of acute and subchronic effects of dothiepin, fluoxetine and placebo on psychomotor and actual driving performance Br J Clin Pharmacol 39 1995 397 404
41. M. Wingen, K.P. Kuypers, V. van de Ven, E. Formisano, and J.G. Ramaekers Sustained attention and serotonin: A pharmaco-fMRI study Hum Psychopharmacol 23 2008 221 230 (Pubitemid 351577692)
42. C.A. Winstanley, Y. Chudasama, J.W. Dalley, D.E. Theobald, J.C. Glennon, and T.W. Robbins Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats Psychopharmacology (Berl) 167 2003 304 314 (Pubitemid 36712978)
43. M. Sarter, and J.P. Bruno Cortical cholinergic inputs mediating arousal, attentional processing and dreaming: Differential afferent regulation of the basal forebrain by telencephalic and brainstem afferents Neuroscience 95 2000 933 952 (Pubitemid 30006882)
44. F. Passetti, J.W. Dalley, M.T. O'Connell, B.J. Everitt, and T.W. Robbins Increased acetylcholine release in the rat medial prefrontal cortex during performance of a visual attentional task Eur J Neurosci 12 2000 3051 3058
45. J. McGaughy, J.W. Dalley, C.H. Morrison, B.J. Everitt, and T.W. Robbins Selective behavioral and neurochemical effects of cholinergic lesions produced by intrabasalis infusions of 192 IgG-saporin on attentional performance in a five-choice serial reaction time task J Neurosci 22 2002 1905 1913 (Pubitemid 35386309)
46. G. Maura, E. Fedele, and M. Raiteri Acetylcholine release from rat hippocampal slices is modulated by 5-hydroxytryptamine Eur J Pharmacol 165 1989 173 179 (Pubitemid 19181784)
47. C. Bianchi, A. Siniscalchi, and L. Beani 5-HT1A agonists increase and 5-HT3 agonists decrease acetylcholine efflux from the cerebral cortex of freely moving guinea-pigs Br J Pharmacol 101 1990 448 452 (Pubitemid 20292904)
48. A. Siniscalchi, L. Beani, and C. Bianchi Different effects of 8-OH-DPAT, a 5-HT1A receptor agonist, on cortical acetylcholine release, electrocortigram and body temperature in guinea pigs and rats Eur J Pharmacol 175 1990 219 223 (Pubitemid 20030162)
49. T.J. Polderman, M.F. Gosso, D. Posthuma, T.C. Van Beijsterveldt, P. Heutink, F.C. Verhulst, and D.I. Boomsma A longitudinal twin study on IQ, executive functioning, and attention problems during childhood and early adolescence Acta Neurol Belg 106 2006 191 207 (Pubitemid 46243057)
50. P. Birkett, T. Sigmundsson, T. Sharma, T. Toulopoulou, T.D. Griffiths, A. Reveley, and R. Murray Reaction time and sustained attention in schizophrenia and its genetic predisposition Schizophr Res 95 2007 76 85 (Pubitemid 47321821)
51. D. Slaats-Willemse, H. Swaab-Barneveld, L. De Sonneville, and J. Buitelaar Familial clustering of executive functioning in affected sibling pair families with ADHD J Am Acad Child Adolesc Psychiatry 44 2005 385 391 (Pubitemid 40393277)
52. E.Y. Levin, B. Levenberg, and S. Kaufman The enzymatic conversion of 3,4-dihydroxyphenylethylamine to norepinephrine J Biol Chem 235 1960 2080 2086
53. M. Kopeckova, I. Paclt, and P. Goetz Polymorphisms and low plasma activity of dopamine-beta-hydroxylase in ADHD children Neuro Endocrinol Lett 27 2006 748 754 (Pubitemid 46138633)
54. Y. Tang, S.G. Buxbaum, I. Waldman, G.M. Anderson, C.P. Zabetian, M.D. Kohnke, and J.F. Cubells A single nucleotide polymorphism at DBH, possibly associated with attention-deficit/hyperactivity disorder, associates with lower plasma dopamine beta-hydroxylase activity and is in linkage disequilibrium with two putative functional single nucleotide polymorphisms Biol Psychiatry 60 2006 1034 1038 (Pubitemid 44647207)
55. N. Bhaduri, and K. Mukhopadhyay Correlation of plasma dopamine beta-hydroxylase activity with polymorphisms in DBH gene: A study on Eastern Indian population Cell Mol Neurobiol 28 2008 343 350
56. J.F. Cubells, and C.P. Zabetian Human genetics of plasma dopamine beta-hydroxylase activity: Applications to research in psychiatry and neurology Psychopharmacology (Berl) 174 2004 463 476 (Pubitemid 39119336)
57. C.P. Zabetian, G.M. Anderson, S.G. Buxbaum, R.C. Elston, H. Ichinose, and T. Nagatsu A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: Evidence for a major functional polymorphism at the DBH locus Am J Hum Genet 68 2001 515 522 (Pubitemid 32147822)
58. Y. Chen, G. Wen, F. Rao, K. Zhang, L. Wang, and J.L. Rodriguez-Flores Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure J Hypertens 28 2010 76 86
59. C. Kieling, J.P. Genro, M.H. Hutz, and L.A. Rohde The -1021 C/T DBH polymorphism is associated with neuropsychological performance among children and adolescents with ADHD Am J Med Genet B Neuropsychiatr Genet 147B 2008 485 490 (Pubitemid 351830808)
60. T. Roman, L.A. Rohde, and M.H. Hutz Polymorphisms of the dopamine transporter gene: Influence on response to methylphenidate in attention deficit-hyperactivity disorder Am J Pharmacogenomics 4 2004 83 92 (Pubitemid 38560315)
61. M.A. Bellgrove, J.B. Mattingley, Z. Hawi, C. Mullins, A. Kirley, M. Gill, and I.H. Robertson Impaired temporal resolution of visual attention and dopamine beta hydroxylase genotype in attention-deficit/hyperactivity disorder Biol Psychiatry 60 2006 1039 1045 (Pubitemid 44647219)
62. C.M. Greene, M.A. Bellgrove, M. Gill, and I.H. Robertson Noradrenergic genotype predicts lapses in sustained attention Neuropsychologia 47 2009 591 594
63. I.R. Gizer, C. Ficks, and I.D. Waldman Candidate gene studies of ADHD: A meta-analytic review Hum Genet 126 2009 51 90
64. M.A. Bellgrove, Z. Hawi, A. Kirley, M. Gill, and I.H. Robertson Dissecting the attention deficit hyperactivity disorder (ADHD) phenotype: Sustained attention, response variability and spatial attentional asymmetries in relation to dopamine transporter (DAT1) genotype Neuropsychologia 43 2005 1847 1857 (Pubitemid 41317401)
65. S.K. Loo, E. Specter, A. Smolen, C. Hopfer, P.D. Teale, and M.L. Reite Functional effects of the DAT1 polymorphism on EEG measures in ADHD J Am Acad Child Adolesc Psychiatry 42 2003 986 993 (Pubitemid 44515849)
66. K. Langley, L. Marshall, M. van den Bree, H. Thomas, M. Owen, and M. O'Donovan Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD Am J Psychiatry 161 2004 133 138 (Pubitemid 38419318)
67. K. Brookes, X. Xu, W. Chen, K. Zhou, B. Neale, and N. Lowe The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: Association signals in DRD4, DAT1 and 16 other genes Mol Psychiatry 11 2006 934 953 (Pubitemid 44470216)
68. S.V. Faraone, A.E. Doyle, E. Mick, and J. Biederman Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder Am J Psychiatry 158 2001 1052 1057 (Pubitemid 32623108)
69. M.A. Bellgrove, Z. Hawi, N. Lowe, A. Kirley, I.H. Robertson, and M. Gill DRD4 gene variants and sustained attention in attention deficit hyperactivity disorder (ADHD): Effects of associated alleles at the VNTR and -521 SNP Am J Med Genet B Neuropsychiatr Genet 136B 2005 81 86 (Pubitemid 40917534)
70. K.A. Johnson, S.P. Kelly, I.H. Robertson, E. Barry, A. Mulligan, and M. Daly Absence of the 7-repeat variant of the DRD4 VNTR is associated with drifting sustained attention in children with ADHD but not in controls Am J Med Genet B Neuropsychiatr Genet 147B 2008 927 937
71. C. Kieling, T. Roman, A.E. Doyle, M.H. Hutz, and L.A. Rohde Association between DRD4 gene and performance of children with ADHD in a test of sustained attention Biol Psychiatry 60 2006 1163 1165 (Pubitemid 44647222)
72. H.H. Van Tol, J.R. Bunzow, H.C. Guan, R.K. Sunahara, P. Seeman, H.B. Niznik, and O. Civelli Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine Nature 350 1991 610 614 (Pubitemid 21912282)
73. J. Lasky-Su, B.M. Neale, B. Franke, R.J. Anney, K. Zhou, and J.B. Maller Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations Am J Med Genet B Neuropsychiatr Genet 147B 2008 1345 1354
74. S.H. Kollins, A.D. Anastopoulos, A.M. Lachiewicz, D. FitzGerald, E. Morrissey-Kane, and M.E. Garrett SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families Am J Med Genet B Neuropsychiatr Genet 147B 2008 1580 1588
75. R. Rodriguez-Jimenez, C. Avila, G. Ponce, M.I. Ibanez, G. Rubio, and J.-A. Ma The TaqIA polymorphism linked to the DRD2 gene is related to lower attention and less inhibitory control in alcoholic patients Eur Psychiatry 21 2006 66 69 (Pubitemid 43243056)
76. M. Bosia, S. Anselmetti, A. Pirovano, E. Ermoli, E. Marino, and P. Bramanti HTTLPR functional polymorphism in schizophrenia: Executive functions vs. sustained attention dissociation Prog Neuropsychopharmacol Biol Psychiatry 34 2009 81 85
77. K.P. Lesch, D. Bengel, A. Heils, S.Z. Sabol, B.D. Greenberg, and S. Petri Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science 274 1996 1527 1531 (Pubitemid 26403928)
78. O.O. Polesskaya, and B.P. Sokolov Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics J Neurosci Res 67 2002 812 822 (Pubitemid 34226294)
79. A. Ucok, H. Alpsan, S. Cakir, and G. Saruhan-Direskeneli Association of a serotonin receptor 2A gene polymorphism with cognitive functions in patients with schizophrenia Am J Med Genet B Neuropsychiatr Genet 144B 2007 704 707 (Pubitemid 47077158)
80. G. Logan, and W. Cowan On the ability to inhibit thought and action: A theory of an act of control Psychol Review 91 1984 295 327
81. C.D. Chambers, H. Garavan, and M.A. Bellgrove Insights into the neural basis of response inhibition from cognitive and clinical neuroscience Neurosci Biobehav Rev 33 2009 631 646
82. J. Crosbie, and R. Schachar Deficient inhibition as a marker for familial ADHD Am J Psychiatry 158 2001 1884 1890 (Pubitemid 33054783)
83. L. Menzies, S. Achard, S.R. Chamberlain, N. Fineberg, C.H. Chen, and N. del Campo Neurocognitive endophenotypes of obsessive-compulsive disorder Brain 130 2007 3223 3236 (Pubitemid 350209066)
84. R.J. Schachar, J. Crosbie, C.L. Barr, T.J. Ornstein, J. Kennedy, and M. Malone Inhibition of motor responses in siblings concordant and discordant for attention deficit hyperactivity disorder Am J Psychiatry 162 2005 1076 1082 (Pubitemid 40770689)
85. G. Logan, R. Schachar, and R. Tannock Impulsivity and inhibitory control Psychol Sci 8 1997 60 64
86. H. Garavan, T.J. Ross, and E.A. Stein Right hemispheric dominance of inhibitory control: An event-related functional MRI study Proc Natl Acad Sci U S A 96 1999 8301 8306 (Pubitemid 29328449)
87. C.S. Li, C. Huang, R.T. Constable, and R. Sinha Imaging response inhibition in a stop-signal task: Neural correlates independent of signal monitoring and post-response processing J Neurosci 26 2006 186 192 (Pubitemid 43089531)
88. C.D. Chambers, M.A. Bellgrove, M.G. Stokes, T.R. Henderson, H. Garavan, and I.H. Robertson Executive "brake failure" following deactivation of human frontal lobe J Cogn Neurosci 18 2006 444 455
89. S. Gauggel, M. Rieger, and T.A. Feghoff Inhibition of ongoing responses in patients with Parkinson's disease J Neurol Neurosurg, Psychiatry 75 2004 539 544 (Pubitemid 38406648)
90. W.P. van den Wildenberg, G.J. van Boxtel, M.W. van der Molen, D.A. Bosch, J.D. Speelman, and C.H. Brunia Stimulation of the subthalamic region facilitates the selection and inhibition of motor responses in Parkinson's disease J Cogn Neurosci 18 2006 626 636 (Pubitemid 43763862)
91. D.M. Eagle, and C. Baunez Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition Neurosci Biobehav Rev 34 2010 50 72
92. A.R. Aron, and R.A. Poldrack Cortical and subcortical contributions to Stop signal response inhibition: Role of the subthalamic nucleus J Neurosci 26 2006 2424 2433 (Pubitemid 44699002)
93. R.G. O'Connell, P.M. Dockree, M.A. Bellgrove, A. Turin, S. Ward, and J.J. Foxe Two types of action error: Electrophysiological evidence for separable inhibitory and sustained attention neural mechanisms producing error on go/no-go tasks J Cogn Neurosci 21 2009 93 104
94. A. Kok, J.R. Ramautar, M.B. De Ruiter, G.P. Band, and K.R. Ridderinkhof ERP components associated with successful and unsuccessful stopping in a stop-signal task Psychophysiology 41 2004 9 20 (Pubitemid 38209024)
95. S.R. Pliszka, M. Liotti, and M.G. Woldorff Inhibitory control in children with attention-deficit/hyperactivity disorder: Event-related potentials identify the processing component and timing of an impaired right-frontal response-inhibition mechanism Biol Psychiatry 48 2000 238 246 (Pubitemid 30618996)
96. E. Sokhadze, C. Stewart, M. Hollifield, and A. Tasman Event-related potential study of executive dysfunctions in a speeded reaction task in cocaine addiction J Neurother 12 2008 185 204
97. M. Ruchsow, G. Groen, M. Kiefer, P. Beschoner, L. Hermle, D. Ebert, and M. Falkenstein Electrophysiological evidence for reduced inhibitory control in depressed patients in partial remission: A Go/Nogo study Int J Psychophysiol 68 2008 209 218
98. M. Ruchsow, K. Reuter, L. Hermle, D. Ebert, M. Kiefer, and M. Falkenstein Executive control in obsessive-compulsive disorder: Event-related potentials in a Go/Nogo task J Neural Transm 114 2007 1595 1601 (Pubitemid 350212006)
99. M.S. Kim, Y.Y. Kim, S.Y. Yoo, and J.S. Kwon Electrophysiological correlates of behavioral response inhibition in patients with obsessive-compulsive disorder Depress Anxiety 24 2007 22 31 (Pubitemid 46278677)
100. A. Bari, D.M. Eagle, A.C. Mar, E.S. Robinson, and T.W. Robbins Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats Psychopharmacology (Berl) 205 2009 2773283
101. D.M. Eagle, A. Bari, and T.W. Robbins The neuropsychopharmacology of action inhibition: Cross-species translation of the stop-signal and go/no-go tasks Psychopharmacology (Berl) 199 2008 439 456
102. S.R. Chamberlain, A. Hampshire, U. Muller, K. Rubia, N. Del Campo, and K. Craig Atomoxetine modulates right inferior frontal activation during inhibitory control: A pharmacological functional magnetic resonance imaging study Biol Psychiatry 65 2009 550 555
103. S.R. Chamberlain, U. Muller, A.D. Blackwell, L. Clark, T.W. Robbins, and B.J. Sahakian Neurochemical modulation of response inhibition and probabilistic learning in humans Science 311 2006 861 863 (Pubitemid 43228852)
104. E.S. Robinson, D.M. Eagle, A.C. Mar, A. Bari, G. Banerjee, and X. Jiang Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat Neuropsychopharmacology 33 2008 1028 1037 (Pubitemid 351367544)
105. D.M. Eagle, M.R. Tufft, H.L. Goodchild, and T.W. Robbins Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol Psychopharmacology (Berl) 192 2007 193 206 (Pubitemid 46669203)
106. K. Rubia, F. Lee, A.J. Cleare, N. Tunstall, C.H. Fu, and M. Brammer Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI Psychopharmacology (Berl) 179 2005 791 803 (Pubitemid 40767899)
107. A.F. Arnsten Catecholamine modulation of prefrontal cortical cognitive function Trends Cogn Sci 2 1998 436 447 (Pubitemid 28518356)
108. T. Sagvolden, E.B. Johansen, H. Aase, and V.A. Russell A dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) predominantly hyperactive/impulsive and combined subtypes Behav Brain Sci 28 2005 397 419 Discussion: 419368 (Pubitemid 41440193)
109. S.R. Pliszka, J.T. McCracken, and J.W. Maas Catecholamines in attention-deficit hyperactivity disorder: Current perspectives J Am Acad Child Adolesc Psychiatry 35 1996 264 272 (Pubitemid 26072283)
110. R. Tannock, R.J. Schachar, R.P. Carr, D. Chajczyk, and G.D. Logan Effects of methylphenidate on inhibitory control in hyperactive children J Abnorm Child Psychol 17 1989 473 491 (Pubitemid 19261803)
111. A.R. Aron, J.H. Dowson, B.J. Sahakian, and T.W. Robbins Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder Biol Psychiatry 54 2003 1465 1468 (Pubitemid 37522172)
112. A.M. Boonstra, J.J. Kooij, J. Oosterlaan, J.A. Sergeant, and J.K. Buitelaar Does methylphenidate improve inhibition and other cognitive abilities in adults with childhood-onset ADHD? J Clin Exp Neuropsychol 27 2005 278 298 (Pubitemid 40523416)
113. L.S. Nandam, R. Hester, J. Wagner, T.D.R. Cummins, K. Garner, and A. Dean Methylphenidate but not atomoxetine or citalopram modulates inhibitory control and response time variability [published online ahead of print December 28] Biol Psychiatry 2010
114. Arnsten AFT (in press): Catecholamine influences on dorsolateral prefrontal cortical networks. Biol Psychiatry.
115. J.W. Mink The basal ganglia: Focused selection and inhibition of competing motor programs Prog Neurobiol 50 1996 381 425 (Pubitemid 27028538)
116. Eagle DM, Allen ME, Wong JCK, Mar AC, Theobald DE, Robbins TW (2008): Different effects of D1 and D2 receptor antagonists on the stopsignal task: Comparison of effects in the dorsomedial striatum and nucleus accumbens core. Presented at the Society For Neuroscience Annual Meeting, Washington, DC.
117. D. Slaats-Willemse, H. Swaab-Barneveld, L. de Sonneville, E. van der Meulen, and J. Buitelaar Deficient response inhibition as a cognitive endophenotype of ADHD J Am Acad Child Adolesc Psychiatry 42 2003 1242 1248 (Pubitemid 39592078)
118. O. Kebir, K. Tabbane, S. Sengupta, and R. Joober Candidate genes and neuropsychological phenotypes in children with ADHD: Review of association studies J Psychiatry Neurosci 34 2009 88 101
119. U.M. Kramer, N. Rojo, R. Schule, T. Cunillera, L. Schols, and J. Marco-Pallares ADHD candidate gene (DRD4 exon III) affects inhibitory control in a healthy sample BMC Neurosci 10 2009 150
120. E. Congdon, K.P. Lesch, and T. Canli Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: Implications for impulsivity Am J Med Genet B Neuropsychiatr Genet 147B 2008 27 32
121. K.M. Cornish, T. Manly, R. Savage, J. Swanson, D. Morisano, and N. Butler Association of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample Mol Psychiatry 10 2005 686 698 (Pubitemid 40961739)
122. A.C. Bedard, K.P. Schulz, E.H. Cook Jr, J. Fan, S.M. Clerkin, and I. Ivanov Dopamine transporter gene variation modulates activation of striatum in youth with ADHD Neuroimage 53 2009 935 942
123. E. Congdon, R.T. Constable, K.P. Lesch, and T. Canli Influence of SLC6A3 and COMT variation on neural activation during response inhibition Biol Psychol 81 2009 144 152
124. S.V. Faraone, and S.A. Khan Candidate gene studies of attention-deficit/hyperactivity disorder J Clin Psychiatry 67 suppl 8 2006 13 20 (Pubitemid 44385602)
125. C. Hess, A. Reif, A. Strobel, A. Boreatti-Hummer, M. Heine, K.P. Lesch, and C.P. Jacob A functional dopamine-beta-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders J Neural Transm 116 2009 121 130
126. L. Passamonti, F. Fera, A. Magariello, A. Cerasa, M.C. Gioia, and M. Muglia Monoamine oxidase-a genetic variations influence brain activity associated with inhibitory control: New insight into the neural correlates of impulsivity Biol Psychiatry 59 2006 334 340 (Pubitemid 43238358)
127. L. Passamonti, A. Cerasa, M.C. Gioia, A. Magariello, M. Muglia, A. Quattrone, and F. Fera Genetically dependent modulation of serotonergic inactivation in the human prefrontal cortex Neuroimage 40 2008 1264 1273
128. L. Clark, J.P. Roiser, R. Cools, D.C. Rubinsztein, B.J. Sahakian, and T.W. Robbins Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: Implications for the 5-HT theory of impulsivity Psychopharmacology (Berl) 182 2005 570 578 (Pubitemid 41464639)
129. S.F. Stoltenberg, J.M. Glass, S.T. Chermack, H.A. Flynn, S. Li, M.E. Weston, and M. Burmeister Possible association between response inhibition and a variant in the brain-expressed tryptophan hydroxylase-2 gene Psychiatr Genet 16 2006 35 38 (Pubitemid 44481218)
130. C.G. Baehne, A.C. Ehlis, M.M. Plichta, A. Conzelmann, P. Pauli, and C. Jacob Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals Mol Psychiatry 14 2009 1032 1039
131. P.M. Rabbitt Errors and error correction in choice-response tasks J Exp Psychol 71 1966 264 272
132. M. Falkenstein, J. Hoormann, S. Christ, and J. Hohnsbein ERP components on reaction errors and their functional significance: A tutorial Biol Psychol 51 2000 87 107 (Pubitemid 30109225)
133. V. van Veen, and C.S. Carter The anterior cingulate as a conflict monitor: fMRI and ERP studies Physiol Behav 77 2002 477 482 (Pubitemid 36084388)
134. C.B. Holroyd, and M.G. Coles The neural basis of human error processing: Reinforcement learning, dopamine, and the error-related negativity Psychol Rev 109 2002 679 709
135. S. Nieuwenhuis, K.R. Ridderinkhof, J. Blom, G.P. Band, and A. Kok Error-related brain potentials are differentially related to awareness of response errors: Evidence from an antisaccade task Psychophysiology 38 2001 752 760 (Pubitemid 32848137)
136. K.A. Kiehl, P.F. Liddle, and J.B. Hopfinger Error processing and the rostral anterior cingulate: An event-related fMRI study Psychophysiology 37 2000 216 223 (Pubitemid 30140286)
137. K.R. Ridderinkhof, M. Ullsperger, E.A. Crone, and S. Nieuwenhuis The role of the medial frontal cortex in cognitive control Science 306 2004 443 447 (Pubitemid 39372436)
138. S. Dehaene, M.I. Posner, and D.M. Tucker Localization of a neural system for error detection and compensation Psychol Sci 5 1994 303 305
139. M.J. Herrmann, J. Rommler, A.C. Ehlis, A. Heidrich, and A.J. Fallgatter Source localization (LORETA) of the error-related-negativity (ERN/Ne) and positivity (Pe) Brain Res Cogn Brain Res 20 2004 294 299 (Pubitemid 38748712)
140. D.A. Peterson, C. Elliott, D.D. Song, S. Makeig, T.J. Sejnowski, and H. Poizner Probabilistic reversal learning is impaired in Parkinson's disease Neuroscience 163 2009 1092 1101
141. M. Falkenstein, H. Hielscher, I. Dziobek, P. Schwarzenau, J. Hoormann, B. Sunderman, and J. Hohnsbein Action monitoring, error detection, and the basal ganglia: An ERP study Neuroreport 12 2001 157 161 (Pubitemid 32099047)
142. R. Willemssen, T. Muller, M. Schwarz, J. Hohnsbein, and M. Falkenstein Error processing in patients with Parkinson's disease: The influence of medication state J Neural Transm 115 2008 461 468
143. B. Stemmer, S.J. Segalowitz, J. Dywan, M. Panisset, and C. Melmed The error negativity in nonmedicated and medicated patients with Parkinson's disease Clin Neurophysiol 118 2007 1223 1229 (Pubitemid 46727099)
144. C.B. Holroyd, P. Praamstra, E. Plat, and M.G. Coles Spared error-related potentials in mild to moderate Parkinson's disease Neuropsychologia 40 2002 2116 2124
145. G. Aston-Jones, and J.D. Cohen Adaptive gain and the role of the locus coeruleus-norepinephrine system in optimal performance J Comp Neurol 493 2005 99 110 (Pubitemid 41637975)
146. K. Shiels, and L.W. Hawk Jr Self-regulation in ADHD: The role of error processing Clin Psychol Rev 30 2010 951 961
147. L.M. Jonkman, J.J. van Melis, C. Kemner, and C.R. Markus Methylphenidate improves deficient error evaluation in children with ADHD: An event-related brain potential study Biol Psychol 76 2007 217 229 (Pubitemid 47575796)
148. K. Rubia, A.B. Smith, E. Taylor, and M. Brammer Linear age-correlated functional development of right inferior fronto-striato-cerebellar networks during response inhibition and anterior cingulate during error-related processes Hum Brain Mapp 28 2007 1163 1177 (Pubitemid 350077481)
149. J.R. Wiersema, J.J. van der Meere, and H. Roeyers Developmental changes in error monitoring: An event-related potential study Neuropsychologia 45 2007 1649 1657 (Pubitemid 46394565)
150. R.G. O'Connell, P.M. Dockree, M.A. Bellgrove, S.P. Kelly, R. Hester, and H. Garavan The role of cingulate cortex in the detection of errors with and without awareness: A high-density electrical mapping study Eur J Neurosci 25 2007 2571 2579 (Pubitemid 46625913)
151. F.X. Vollenweider, R.P. Maguire, K.L. Leenders, K. Mathys, and J. Angst Effects of high amphetamine dose on mood and cerebral glucose metabolism in normal volunteers using positron emission tomography PET Psychiatry Res 83 1998 149 162 (Pubitemid 28522506)
152. E.R. de Bruijn, W. Hulstijn, R.J. Verkes, G.S. Ruigt, and B.G. Sabbe Drug-induced stimulation and suppression of action monitoring in healthy volunteers Psychopharmacology (Berl) 177 2004 151 160 (Pubitemid 40109925)
153. N. Easton, C. Steward, F. Marshall, K. Fone, and C. Marsden Effects of amphetamine isomers, methylphenidate and atomoxetine on synaptosomal and synaptic vesicle accumulation and release of dopamine and noradrenaline in vitro in the rat brain Neuropharmacology 52 2007 405 414 (Pubitemid 46137974)
154. M.A. Nader, D. Morgan, H.D. Gage, S.H. Nader, T.L. Calhoun, and N. Buchheimer PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys Nat Neurosci 9 2006 1050 1056 (Pubitemid 44264918)
155. N.D. Volkow, J.S. Fowler, G.J. Wang, R. Hitzemann, J. Logan, and D.J. Schlyer Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers Synapse 14 1993 169 177 (Pubitemid 23157765)
156. G. Schoenbaum, and B. Setlow Cocaine makes actions insensitive to outcomes but not extinction: Implications for altered orbitofrontal-amygdalar function Cereb Cortex 15 2005 1162 1169 (Pubitemid 41373609)
157. I.H. Franken, J.W. van Strien, E.J. Franzek, and B.J. van de Wetering Error-processing deficits in patients with cocaine dependence Biol Psychol 75 2007 45 51 (Pubitemid 46400969)
158. P.J. Zirnheld, C.A. Carroll, P.D. Kieffaber, B.F. O'Donnell, A. Shekhar, and W.P. Hetrick Haloperidol impairs learning and error-related negativity in humans J Cogn Neurosci 16 2004 1098 1112 (Pubitemid 38998785)
159. C.W. Berridge, and B.D. Waterhouse The locus coeruleus-noradrenergic system: Modulation of behavioral state and state-dependent cognitive processes Brain Res Brain Res Rev 42 2003 33 84 (Pubitemid 36369264)
160. L. Scahill, P.B. Chappell, Y.S. Kim, R.T. Schultz, L. Katsovich, and E. Shepherd A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder Am J Psychiatry 158 2001 1067 1074 (Pubitemid 32623110)
161. J. Riba, A. Rodriguez-Fornells, A. Morte, T.F. Munte, and M.J. Barbanoj Noradrenergic stimulation enhances human action monitoring J Neurosci 25 2005 4370 4374 (Pubitemid 40628781)
162. M.J. Millan, A. Newman-Tancredi, V. Audinot, D. Cussac, F. Lejeune, and J.P. Nicolas Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT), 1A, 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors Significance for the modulation of frontocortical monoaminergic transmission and depressive states Synapse 35 2000 79 95 (Pubitemid 30036185)
163. A. Ivanov, and G. Aston-Jones Extranuclear dendrites of locus coeruleus neurons: Activation by glutamate and modulation of activity by alpha adrenoceptors J Neurophysiol 74 1995 2427 2436 (Pubitemid 26012303)
164. K. Starke, M. Gothert, and H. Kilbinger Modulation of neurotransmitter release by presynaptic autoreceptors Physiol Rev 69 1989 864 989 (Pubitemid 19184852)
165. R.M. Wenzlaff, and S.A. Grozier Depression and the magnification of failure J Abnorm Psychol 97 1988 90 93 (Pubitemid 18053269)
166. A.J. Holmes, and D.A. Pizzagalli Spatiotemporal dynamics of error processing dysfunctions in major depressive disorder Arch Gen Psychiatry 65 2008 179 188 (Pubitemid 351214317)
167. E.R. de Bruijn, B.G. Sabbe, W. Hulstijn, G.S. Ruigt, and R.J. Verkes Effects of antipsychotic and antidepressant drugs on action monitoring in healthy volunteers Brain Res 1105 2006 122 129 (Pubitemid 44175961)
168. E.A. Evers, F.M. van der Veen, J.A. van Deursen, J.A. Schmitt, N.E. Deutz, and J. Jolles The effect of acute tryptophan depletion on the BOLD response during performance monitoring and response inhibition in healthy male volunteers Psychopharmacology (Berl) 187 2006 200 208 (Pubitemid 44015614)
169. N.S. Narayanan, and M. Laubach Neuronal correlates of post-error slowing in the rat dorsomedial prefrontal cortex J Neurophysiol 100 2008 520 525
170. F.M. van der Veen, G.W. Mies, M.W. van der Molen, and E.A. Evers Acute tryptophan depletion in healthy males attenuates phasic cardiac slowing but does not affect electro-cortical response to negative feedback Psychopharmacology (Berl) 199 2008 255 263
171. E.A. Evers, F.M. van der Veen, D. Fekkes, and J. Jolles Serotonin and cognitive flexibility: Neuroimaging studies into the effect of acute tryptophan depletion in healthy volunteers Curr Med Chem 14 2007 2989 2995 (Pubitemid 350226968)
172. B. Albrecht, D. Brandeis, H. Uebel, H. Heinrich, U.C. Mueller, and M. Hasselhorn Action monitoring in boys with attention-deficit/hyperactivity disorder, their nonaffected siblings, and normal control subjects: Evidence for an endophenotype Biol Psychiatry 64 2008 615 625
173. U.M. Krmer, T. Cunillera, E. Camara, J. Marco-Pallares, D. Cucurell, and W. Nager The impact of catechol-O-methyltransferase and dopamine D4 receptor genotypes on neurophysiological markers of performance monitoring J Neurosci 27 2007 14190 14198 (Pubitemid 351377871)
174. Y. Okuyama, H. Ishiguro, M. Toru, and T. Arinami A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia Biochem Biophys Res Commun 258 1999 292 295 (Pubitemid 29287044)
175. J. Simpson, G. Vetuz, M. Wilson, K.J. Brookes, and L. Kent The DRD4 receptor Exon 3 VNTR and 5′ SNP variants and mRNA expression in human post-mortem brain tissue Am J Med Genet B Neuropsychiatr Genet 153B 2010 1228 1233
176. E. Kereszturi, O. Kiraly, C. Barta, N. Molnar, M. Sasvari-Szekely, and Z. Csapo No direct effect of the -521 C/T polymorphism in the human dopamine D4 receptor gene promoter on transcriptional activity BMC Mol Biol 7 2006 18
177. E.G. Jonsson, M.M. Nothen, F. Grunhage, L. Farde, Y. Nakashima, P. Propping, and G.C. Sedvall Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers Mol Psychiatry 4 1999 290 296 (Pubitemid 29292183)
178. T. Pohjalainen, J.O. Rinne, K. Nagren, P. Lehikoinen, K. Anttila, E.K. Syvalahti, and J. Hietala The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers Mol Psychiatry 3 1998 256 260 (Pubitemid 28266335)
179. E.P. Noble, K. Blum, T. Ritchie, A. Montgomery, and P.J. Sheridan Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism Arch Gen Psychiatry 48 1991 648 654
180. T.A. Klein, J. Neumann, M. Reuter, J. Hennig, D.Y. von Cramon, and M. Ullsperger Genetically determined differences in learning from errors Science 318 2007 1642 1645 (Pubitemid 350233666)
181. M. Althaus, Y. Groen, A.A. Wijers, L.J. Mulder, R.B. Minderaa, and I.P. Kema Differential effects of 5-HTTLPR and DRD2/ANKK1 polymorphisms on electrocortical measures of error and feedback processing in children Clin Neurophysiol 120 2009 93 107
182. A.J. Fallgatter, M.J. Herrmann, J. Roemmler, A.C. Ehlis, A. Wagener, and A. Heidrich Allelic variation of serotonin transporter function modulates the brain electrical response for error processing Neuropsychopharmacology 29 2004 1506 1511 (Pubitemid 38982243)
183. A.J. Holmes, R. Bogdan, and D.A. Pizzagalli Serotonin transporter genotype and action monitoring dysfunction: A possible substrate underlying increased vulnerability to depression Neuropsychopharmacology 35 2010 1186 1197
184. C. Beste, K. Domschke, V. Kolev, J. Yordanova, A. Baffa, and M. Falkenstein Functional 5-HT1A receptor polymorphism selectively modulates error-specific subprocesses of performance monitoring Hum Brain Mapp 31 2009 621 630
185. S. Lemonde, G. Turecki, D. Bakish, L. Du, P.D. Hrdina, and C.D. Bown Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide J Neurosci 23 2003 8788 8799 (Pubitemid 37176660)
186. G.M. Sullivan, R.T. Ogden, M.A. Oquendo, J.S. Kumar, N. Simpson, and Y.Y. Huang Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression Biol Psychiatry 66 2009 223 230