A preliminary study of gene polymorphisms involved in the neurotransmitters metabolism of a homogeneous Spanish autistic group

Research in Autism Spectrum Disorders

Volumn 3, Issue 2, 2009, Pages 438-443

  Calahorro, Fernando ^a   Alejandre, Encarna ^a   Anaya, Nuria ^a   Guijarro, Teresa ^b   Sanz, Yolanza ^b   Romero, Auxiliadora ^b   Tienda, Pilar ^b   Burgos, Rafael ^b   Gay, Eudoxia ^b   Sánchez, Vicente ^b   Ruiz Rubio, Manuel ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

^b HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

Autism; DAT1; Dopamine; DRD4; MAO A; Serotonin; SLC6A4

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); DOPAMINE TRANSPORTER; NEUROTRANSMITTER; SEROTONIN TRANSPORTER;

ARTICLE; AUTISM; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; EXTRACHROMOSOMAL INHERITANCE; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; MALE; MUTATIONAL ANALYSIS; NEUROPATHOLOGY; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METABOLISM; SEROTONINERGIC SYSTEM; SPAIN; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 60849096640     PISSN: 17509467     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rasd.2008.09.003     Document Type: Article

References (16)

1. Anderson G.M., Freedman D.X., Cohen D.J., Volkmar F.R., Hoder E.L., McPhedran P., et al. Whole blood serotonin in autistic and normal subjects. Journal of Child Psychology and Psychiatry 28 (1987) 885-900
2. Bacchelli E., and Maestrini E. Autism spectrum disorders: Molecular genetic advances. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 142 (2006) 13-23
3. Devlin B., Cook Jr. E.H., Coon H., Dawson G., Grigorenko E.L., McMahon W., et al. Autism and the serotonin transporter: The long and short of it. Molecular Psychiatry 10 (2005) 1110-1116
4. Faraone S.V., Perlis R.H., Doyle A.E., Smoller J.W., Goralnick J.J., Holmgren M.A., et al. Molecular genetics of attention-deficit/hyperactivity disorder. Biological Psychiatry 57 (2005) 1313-1323
5. Geschwind D.H., and Levitt P. Autism spectrum disorders: Developmental disconnection syndromes. Current Opinion in Neurobiology 17 (2007) 103-111
6. Grady D.L., Harxhi A., Smith M., Flodman P., Spence M.A., Swanson J.M., et al. Sequence variants of the DRD4 gene in autism: further evidence that rare DRD4 7R haplotypes are ADHD specific. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 136 (2005) 33-35
7. Gupta A.R., and State M.W. Recent advances in the genetics of autism. Biological Psychiatry 61 (2007) 429-437
8. Hollander E., Phillips A., Chaplin W., Zagursky K., Novotny S., Wasserman S., et al. A placebo controlled crossover trial of liquid fluoxetine on repetitive behaviors in childhood and adolescent autism. Neuropsychopharmacology 30 (2005) 582-589
9. Klauck S.M., Poustka F., Benner A., Lesch K.P., and Poustka A. Serotonin transporter (5-HTT) gene variants associated with autism?. Human Molecular Genetics 6 (1997) 2233-2238
10. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 5292 (1996) 1527-1531
11. Lim M.H., Kim H.W., Paik K.C., Cho S.C., Yoon D.Y., and Lee H.J. Association of the DAT1 polymorphism with attention deficit hyperactivity disorder (ADHD): A family-based approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141 (2006) 309-311
12. McDougle C.J., Naylor S.T., Cohen D.J., Volkmar F.R., Heninger G.R., and Price L.H. A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Archives of General Psychiatry 53 (1996) 1001-1008
13. Popova N.K. From genes to aggressive behavior: The role of serotonergic system. Bioessays 28 (2006) 495-503
14. Sabol S.Z., Hu S., and Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Human Genetics 103 (1998) 273-279
15. Vandenbergh D.J., Persico A.M., Hawkins A.L., Griffin C.A., Li X., Jabs E.W., et al. Human dopamine transporter gene (DAT1) maps to chromosome 5p15 3 and displays a VNTR. Genomics 14 (1992) 1104-1106
16. Wang E., Ding Y.C., Flodman P., Kidd J.R., Kidd K.K., Grady D.L., et al. The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. American Journal of Human Genetics 74 (2004) 931-944