An update on ABCB1 pharmacogenetics: Insights from a 3D model into the location and evolutionary conservation of residues corresponding to SNPs associated with drug pharmacokinetics

Pharmacogenomics Journal

Volumn 11, Issue 5, 2011, Pages 315-325

  Wolf, S J ^a   Bachtiar, M ^a   Wang, J ^a   Sim, T S ^a   Chong, S S ^a   Lee, C G L ^a,b,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

ABCB1; drug resistance; drug transporter; MDR1; P glycoprotein; SNP

Indexed keywords

ASPARTIC ACID; CYCLOSPORIN A; DOXORUBICIN; ETOPOSIDE; ISOLEUCINE; LYSINE; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; RITONAVIR; SAQUINAVIR; VALINE; VINBLASTINE; VINCRISTINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BETA SHEET; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTAL STRUCTURE; DRUG PENETRATION; DRUG RESPONSE; DRUG SPECIFICITY; DRUG TRANSPORT; ENZYME SUBSTRATE; GENE FREQUENCY; GENE MAPPING; GENETIC CONSERVATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HYDROPHILICITY; NONHUMAN; OVARY CANCER; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; RNA PROCESSING; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; CONSERVED SEQUENCE; DRUG RESISTANCE, MULTIPLE; EVOLUTION, MOLECULAR; HUMANS; INDIVIDUALIZED MEDICINE; MICE; OPEN READING FRAMES; P-GLYCOPROTEIN; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 80053561984     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/tpj.2011.16     Document Type: Review

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