MDR1 C2005T polymorphism changes substrate specificity

Cancer Chemotherapy and Pharmacology

Volumn 66, Issue 3, 2010, Pages 617-623

  Liu, Lijuan ^a   Fan, Lan ^a   Peng, Xiangdong ^a   Hu, Dongli ^a   Zhou, Honghao ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

LLC PK1 cell; MDR1; P glycoprotein; Polymorphism; Transepithelial permeability

Indexed keywords

ETOPOSIDE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; VINBLASTINE; VINCRISTINE; ABCB1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; GLYCOPROTEIN P; RHODAMINE 123;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG PROTEIN BINDING; EFFUSION; ENZYME SPECIFICITY; GENE EXPRESSION; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; IC 50; MEMBRANE PERMEABILITY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; ANIMAL; CELL LINE; CELL MEMBRANE; CONFOCAL MICROSCOPY; DRUG RESISTANCE; EPITHELIUM CELL; GENETIC TRANSFECTION; GENETICS; METABOLISM; PERMEABILITY; POLYMERASE CHAIN REACTION; SWINE; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CELL LINE; CELL MEMBRANE; DRUG RESISTANCE; EPITHELIAL CELLS; INHIBITORY CONCENTRATION 50; MICROSCOPY, CONFOCAL; P-GLYCOPROTEIN; PERMEABILITY; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RHODAMINE 123; RNA, MESSENGER; SUBSTRATE SPECIFICITY; SWINE; TRANSFECTION;

EID: 77954687352     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-010-1308-y     Document Type: Article

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