A comprehensive histopathological evaluation of vascular medial fibrosis: Insights into the pathophysiology of arterial stiffening

Atherosclerosis

Volumn 208, Issue 1, 2010, Pages 69-74

  Selvin, Elizabeth ^a   Najjar, Samer S ^b   Cornish, Toby C ^a   Halushka, Marc K ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Arteriosclerosis; Fibrosis; Image analysis; Tissue microarrays

Indexed keywords

ADULT; AGE; AGED; ARTERIAL STIFFNESS; ARTICLE; ATHEROSCLEROSIS; AUTOPSY; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIABETES MELLITUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERTENSION; KIDNEY FUNCTION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PULSE PRESSURE; STAINING; TISSUE MICROARRAY; TUNICA MEDIA; VASCULAR FIBROSIS;

ADULT; AGED; AGED, 80 AND OVER; ARTERIES; CADAVER; FEMALE; FIBROSIS; HUMANS; MALE; MIDDLE AGED; TUNICA MEDIA; YOUNG ADULT;

EID: 73449123684     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2009.06.025     Document Type: Article

References (30)

1. Grundy S.M., Pasternak R., Greenland P., Smith Jr. S., and Fuster V. Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology. Circulation 100 (1999) 1481-1492
2. Yusuf S., Hawken S., Ounpuu S., et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 364 (2004) 937-952
3. Greenwald S.E. Ageing of the conduit arteries. J Pathol 211 (2007) 157-172
4. O'Rourke M.F. Arterial aging: pathophysiological principles. Vasc Med 12 (2007) 329-341
5. Mattace-Raso F.U., van der Cammen T.J., Hofman A., et al. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 113 (2006) 657-663
6. Najjar S.S., Scuteri A., Shetty V., et al. Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging. J Am Coll Cardiol 51 (2008) 1377-1383
7. Laurent S., Boutouyrie P., Asmar R., et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37 (2001) 1236-1241
8. Willum-Hansen T., Staessen J.A., Torp-Pedersen C., et al. Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population. Circulation 113 (2006) 664-670
9. Sutton-Tyrrell K., Najjar S.S., Boudreau R.M., et al. Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation 111 (2005) 3384-3390
10. Blacher J., Guerin A.P., Pannier B., et al. Impact of aortic stiffness on survival in end-stage renal disease. Circulation 99 (1999) 2434-2439
11. Najjar S.S., and Lakatta E.G. 29 vascular aging. In: Runge M.S., and Patterson C. (Eds). Contemporary cardiology: principles of molecular cardiology (2005), Humana Press, Inc, Totowa, NJ 517-547
12. Homme J.L., Aubry M.C., Edwards W.D., et al. Surgical pathology of the ascending aorta: a clinicopathologic study of 513 cases. Am J Surg Pathol 30 (2006) 1159-1168
13. Halushka M.K., Selvin E., Lu J., Macgregor A.M., and Cornish T.C. The use of human vascular tissue microarrays for measurement of advanced glycation end products. J Histochem Cytochem 57 (2009) 559-566
14. Schlatmann T.J., and Becker A.E. Histologic changes in the normal aging aorta: implications for dissecting aortic aneurysm. Am J Cardiol 39 (1977) 13-20
15. Spina M., Garbisa S., Hinnie J., Hunter J.C., and Serafini-Fracassini A. Age-related changes in composition and mechanical properties of the tunica media of the upper thoracic human aorta. Arteriosclerosis 3 (1983) 64-76
16. Hosoda Y., Kawano K., Yamasawa F., et al. Age-dependent changes of collagen and elastin content in human aorta and pulmonary artery. Angiology 35 (1984) 615-621
17. Clausen B. Influence of age on connective tissue. Hexosamine and hydroxyproline in human aorta, myocardium, and skin. Lab Invest 11 (1962) 229-234
18. Toda T., Tsuda N., Nishimori I., Leszczynski D.E., and Kummerow F.A. Morphometrical analysis of the aging process in human arteries and aorta. Acta Anat (Basel) 106 (1980) 35-44
19. Ruengsakulrach P., Sinclair R., Komeda M., et al. Comparative histopathology of radial artery versus internal thoracic artery and risk factors for development of intimal hyperplasia and atherosclerosis. Circulation 100 (1999) II139-II144
20. Mitchell J.R., and Schwartz C.J. Relationship between arterial disease in different sites. A study of the aorta and coronary, carotid, and iliac arteries. Br Med J 1 (1962) 1293-1301
21. Virmani R., Avolio A.P., Mergner W.J., et al. Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis. Comparison between occidental and Chinese communities. Am J Pathol 139 (1991) 1119-1129
22. Cattell M.A., Anderson J.C., and Hasleton P.S. Age-related changes in amounts and concentrations of collagen and elastin in normotensive human thoracic aorta. Clin Chim Acta 245 (1996) 73-84
23. Halushka M.K., Cornish T.C., Lu J., Selvin L., and Selvin E. Creation, validation, and quantitative analysis of protein expression in vascular tissue microarrays. Cardiovasc Pathol (2009) 10.1016/j.carpath.2008.12.007
24. Shock NW, Gruelich RC, Andres RA, et al. Normal human aging. The Baltimore Longitudinal Study of Aging. Washington, DC, U.S. Government Printing Office; 1984.
25. Cornish T.C., De Marzo A.M., Gurel B., and Morgan J. FRIDA: an open source framework for image dataset analysis. Arch Pathol Lab Med 132 (2008) 856
26. Ruifrok A.C., Katz R.L., and Johnston D.A. Comparison of quantification of histochemical staining by hue-saturation-intensity (HSI) transformation and color-deconvolution. Appl Immunohistochem Mol Morphol 11 (2003) 85-91
27. Najjar S.S., Scuteri A., and Lakatta E.G. Arterial aging: is it an immutable cardiovascular risk factor?. Hypertension 46 (2005) 454-462
28. Lakatta E.G. Central arterial aging and the epidemic of systolic hypertension and atherosclerosis. JASH 1 (2007) 302-340
29. Safar M.E., Blacher J., Mourad J.J., and London G.M. Stiffness of carotid artery wall material and blood pressure in humans: application to antihypertensive therapy and stroke prevention. Stroke 31 (2000) 782-790
30. Guerin A.P., Blacher J., Pannier B., et al. Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure. Circulation 103 (2001) 987-992