Synthesis of 5-substituted-1H-indol-2-yl-1H-quinolin-2-ones: A novel class of KDR kinase inhibitors

Journal of Organic Chemistry

Volumn 70, Issue 7, 2005, Pages 2555-2567

  Kuethe, Jeffrey T ^a   Wong, Audrey ^a   Qu, Chuanxing ^a   Smitrovich, Jacqueline ^a   Davies, Ian W ^a   Hughes, David L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REACTION KINETICS; SYNTHESIS (CHEMICAL);

INDOLE 25; NITROKETONE; TARGET COMPOUNDS;

AROMATIC HYDROCARBONS;

1 (2 METHOXYQUINOLIN 3 YL) 2 [5 [[4 (METHYLSULFONYL)PIPERAZIN 1 YL]METHYL] 2 NITROPHENYL]ETHANONE; 1 METHYSULFONYL 4 (4 NITRO 3 TRIMETHYLSILANYLMETHYLBENZYL)PIPERAZINE; 2 [5 (4 METHANESULFONYLPIPERAZIN 1 YLMETHYL) 2 NITROPHENYL] 1 (2 METHOXYQUINOLIN 3 YL)ETHANOL; 2 METHOXY 3 [5 [[4 (METHYSULFONYL) 1 PIPERAZINYL]METHYL] 1H INDOL 2 YL]QUINOLINE; 2 METHOXYQUINOLINE 3 CARBOXALDEHYDE; 3 [1 [[4 (4 METHANESULFONYLPIPERAZIN 1 YLMETHYL)PHENYL]HYDRAZONO]ETHYL] 1H QUINOLIN 2 ONE; 3 [2 [5 (4 METHANESULFONYLPIPERAZIN 1 YLMETHYL) 2 NITROPHENYL]VINYL] 2 METHOXYQUINOLINE; 3 ACETYL 1H QUINOLIN 2 ONE; ALCOHOL DERIVATIVE; ALDEHYDE DERIVATIVE; BENZENE DERIVATIVE; INDOLE DERIVATIVE; KETONE DERIVATIVE; PHOSPHOTRANSFERASE INHIBITOR; QUINOLINE DERIVATIVE; STYRENE DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; ENZYME INHIBITION; REDUCTION; SUBSTITUTION REACTION;

ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; QUINOLONES; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 17044375054     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0480545     Document Type: Article

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