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Volumn 62, Issue 24, 1997, Pages 8449-8454

A New Regioselective Synthesis of 1,2,5-Trisubstituted 1H-Imidazoles and Its Application to the Development of Eprosartan

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EID: 0001656259     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo971304f     Document Type: Article
Times cited : (76)

References (24)
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    • For other angiotensin II receptor antagonists, see (and references within): (a) Carini, D. J.; Duncia, J. V.; Johnson, A. L.; Chiu, A. T.; Price, W. A.; Wong, P. C.; Timmermans, P. B. J. Med. Chem. 1990, 33, 1330. (b) Carini, D. J.; Duncia, J. V.; Aldrich, P. E.; Chiu, A. T.; Johnson, A. L.; Pierce, M. E.; Price, W. A.; Santella, J. B., III; Wells, G. J.; Wexler, R. R.; Wong, P. C.; Yoo, S. E.; Timmermans, P. B. J. Med. Chem. 1991, 34, 2525. (c) Pierce, M. E.; Carini, D. J.; Huhn, G. F.; Wells, G. J.; Arnett, J. F. J. Org. Chem. 1993, 58, 4642. (d) Furukawa, Y.; Kishimoto, S.; Nishikawa, K. U.S. Patent 4,355,040 1982.
    • (1990) J. Med. Chem. , vol.33 , pp. 1330
    • Carini, D.J.1    Duncia, J.V.2    Johnson, A.L.3    Chiu, A.T.4    Price, W.A.5    Wong, P.C.6    Timmermans, P.B.7
  • 4
    • 0027486067 scopus 로고
    • For other angiotensin II receptor antagonists, see (and references within): (a) Carini, D. J.; Duncia, J. V.; Johnson, A. L.; Chiu, A. T.; Price, W. A.; Wong, P. C.; Timmermans, P. B. J. Med. Chem. 1990, 33, 1330. (b) Carini, D. J.; Duncia, J. V.; Aldrich, P. E.; Chiu, A. T.; Johnson, A. L.; Pierce, M. E.; Price, W. A.; Santella, J. B., III; Wells, G. J.; Wexler, R. R.; Wong, P. C.; Yoo, S. E.; Timmermans, P. B. J. Med. Chem. 1991, 34, 2525. (c) Pierce, M. E.; Carini, D. J.; Huhn, G. F.; Wells, G. J.; Arnett, J. F. J. Org. Chem. 1993, 58, 4642. (d) Furukawa, Y.; Kishimoto, S.; Nishikawa, K. U.S. Patent 4,355,040 1982.
    • (1993) J. Org. Chem. , vol.58 , pp. 4642
    • Pierce, M.E.1    Carini, D.J.2    Huhn, G.F.3    Wells, G.J.4    Arnett, J.F.5
  • 5
    • 1542584968 scopus 로고    scopus 로고
    • U.S. Patent 4,355,040 1982
    • For other angiotensin II receptor antagonists, see (and references within): (a) Carini, D. J.; Duncia, J. V.; Johnson, A. L.; Chiu, A. T.; Price, W. A.; Wong, P. C.; Timmermans, P. B. J. Med. Chem. 1990, 33, 1330. (b) Carini, D. J.; Duncia, J. V.; Aldrich, P. E.; Chiu, A. T.; Johnson, A. L.; Pierce, M. E.; Price, W. A.; Santella, J. B., III; Wells, G. J.; Wexler, R. R.; Wong, P. C.; Yoo, S. E.; Timmermans, P. B. J. Med. Chem. 1991, 34, 2525. (c) Pierce, M. E.; Carini, D. J.; Huhn, G. F.; Wells, G. J.; Arnett, J. F. J. Org. Chem. 1993, 58, 4642. (d) Furukawa, Y.; Kishimoto, S.; Nishikawa, K. U.S. Patent 4,355,040 1982.
    • Furukawa, Y.1    Kishimoto, S.2    Nishikawa, K.3
  • 9
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    • For a general review see: (a) Shriner, R. L.; Neumann, F. W. Chem. Rev. (Washington, D.C.) 1944, 35, 351. (b) Miocque, M.; Fauran, C.; Le Cloarec, A. Y. Ann. Chim. 1972, 7, 89.
    • (1972) Ann. Chim. , vol.7 , pp. 89
    • Miocque, M.1    Fauran, C.2    Le Cloarec, A.Y.3
  • 16
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    • U.S. Patent 3,824,292, 1974
    • Kirby, J. A. U.S. Patent 3,824,292, 1974.
    • Kirby, J.A.1
  • 18
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    • U.S. Patent 4,194,049, 1980
    • Field, G. F.; Zally, W. J. U.S. Patent 4,194,049, 1980.
    • Field, G.F.1    Zally, W.J.2
  • 23
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    • Patai, S., Ed.; John Wiley & Sons; New York, Chapter 7
    • For a general review of the reactions of amidines with α,β-unsaturated esters, nitriles, and carbonyl derivatives, see Gautier, J.; Miocque, M.; Farnoux, C. C. In The Chemistry of Amidines and Initiates; Patai, S., Ed.; John Wiley & Sons; New York, 1975; Chapter 7, p 324-331.
    • (1975) The Chemistry of Amidines and Initiates , pp. 324-331
    • Gautier, J.1    Miocque, M.2    Farnoux, C.C.3


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