Synthesis of new indeno[1,2-e]pyrimido[4,5-b][1,4]diazepine-5,11-diones as potential antitumor agents

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 18, 2008, Pages 8492-8500

  Insuasty, Braulio ^a   Orozco, Fabian ^a   Lizarazo, Carolina ^a   Quiroga, Jairo ^a   Abonia, Rodrigo ^a   Hursthouse, Mike ^b   Nogueras, Manuel ^c   Cobo, Justo ^c  

^a UNIVERSIDAD DEL VALLE   (Colombia)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY OF JAÉN   (Spain)

Author keywords

2 Arylideneindandiones; 5,6 Diamino 3,4 dihydropyrimidin 4 ones; Antitumoral; Indenopyrimido 4,5 b 1,4 diazepine; Regioselective cyclocondensation

Indexed keywords

2 ARYLIDENEINDANDIONE; 5,6 DIAMINO 3,4 DIHYDROPYRIMIDIN 4 ONE; 9 METHYLTHIO 6 (4 FLUOROPHENYL) 6,7,10,12 TETRAHYDROINDENO[1,2 E]PYRIMIDO[4,5 B][1,4]DIAZEPINE 5,11 DIONE; 9 METHYLTHIO 6 PHENYL 6,7,10,12 TETRAHYDROINDENO[1,2 E]PYRIMIDO[4,5 B][1,4]DIAZEPINE 5,11 DIONE; ANTINEOPLASTIC AGENT; DIAZEPINE DERIVATIVE; INDAN DERIVATIVE; INDENO[1,2 E]PYRIMIDO[4,5 B][1,4]DIAZEPINE 5,11 DIONE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN CANCER; BREAST CANCER; CARBON NUCLEAR MAGNETIC RESONANCE; COLON CANCER; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; KIDNEY CANCER; LEUKEMIA; LUNG CANCER; MASS SPECTROMETRY; MELANOMA; OVARY CANCER; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR CELL CULTURE; X RAY DIFFRACTION;

ANTINEOPLASTIC AGENTS; AZEPINES; CELL LINE, TUMOR; DIBENZAZEPINES; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; PYRIMIDINES; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 51449111470     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.023     Document Type: Article

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