Chemistry of the pyrrolo[1,2-a]benzimidazole antitumor agents: Influence of the 7-substituent on the ability to alkylate DNA and inhibit topoisomerase II

Journal of Medicinal Chemistry

Volumn 39, Issue 21, 1996, Pages 4321-4331

  Zhou, Ru ^a   Skibo, Edward B ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DNA ALKYLATION; DRUG CONFORMATION; DRUG STRUCTURE; ENZYME INHIBITION; HYDROLYSIS; INTERCALATION COMPLEX; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALKYLATION; ANIMALS; ANTINEOPLASTIC AGENTS; AZIRIDINES; BENZIMIDAZOLES; CATTLE; DNA; DNA TOPOISOMERASES, TYPE II; DROSOPHILA MELANOGASTER; HYDROLYSIS; KINETICS; THYMUS GLAND;

EID: 0029797555     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960064d     Document Type: Article

References (33)

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