Microwave induced synthesis of novel 8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepines as potential antitumor agents

European Journal of Medicinal Chemistry

Volumn 43, Issue 9, 2008, Pages 1955-1962

  Insuasty, Braulio ^a   Orozco, Fabián ^a   Quiroga, Jairo ^a   Abonia, Rodrigo ^a   Nogueras, Manuel ^b   Cobo, Justo ^b  

^a UNIVERSIDAD DEL VALLE   (Colombia)

^b UNIVERSITY OF JAÉN   (Spain)

Author keywords

4,5,6 Triaminopyrimidine; Antitumoral; Methylenedioxychalcones; Microwave; Pyrimido 4,5 b 1,4 diazepine; Regioselective cyclocondensation

Indexed keywords

4,5,6 TRIAMINOPYRIMIDINE; 8,9 DIHYDRO 7H PYRIMIDO[4,5 B][1,4]DIAZEPINE DERIVATIVE; ANTINEOPLASTIC AGENT; DIAZEPINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROWAVE IRRADIATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; AZEPINES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; HUMANS; LETHAL DOSE 50; MICROWAVES;

EID: 51149095394     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.12.005     Document Type: Article

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