Synthesis of novel pyrazolic analogues of chalcones and their 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazole derivatives as potential antitumor agents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 14, 2010, Pages 4965-4974

  Insuasty, Braulio ^a   Tigreros, Alexis ^a   Orozco, Fabián ^b   Quiroga, Jairo ^a   Abonía, Rodrigo ^a   Nogueras, Manuel ^c   Sanchez, Adolfo ^c   Cobo, Justo ^c  

^a UNIVERSIDAD DEL VALLE   (Colombia)

^b UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

^c UNIVERSITY OF JAÉN   (Spain)

Author keywords

Antitumoral agents; Claisen Schmidt reaction; Cyclocondensation reaction; Functionalized dihydropyrazoles; Microwave irradiation; Pyrazolic chalcones

Indexed keywords

1 (4 CHLOROPHENYL) 3 [3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]PROP 2 EN 1 ONE; 1 ACETYL 5 [3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 3 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLE; ACETIC ACID; ACETOPHENONE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; CHALCONE DERIVATIVE; N,N DIMETHYLFORMAMIDE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CHEMICAL REACTION; CLAISEN SCHMIDT REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIZATION; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROWAVE IRRADIATION; POLYMERIZATION;

ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CHALCONES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; KIDNEY NEOPLASMS; LEUKEMIA; LUNG NEOPLASMS; NEOPLASMS; PYRAZOLES;

EID: 77955322921     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.013     Document Type: Article

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