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Volumn 36, Issue 8, 2011, Pages 601-613

Recent advances in positron emission tomography imaging of brain

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ATOMOXETINE; BAPINEUZUMAB; BIOLOGICAL MARKER; CARBON 11; FLUORINE 18; GADOLINIUM; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NISOXETINE; NORADRENALIN TRANSPORTER; PBR 28; PLACEBO; RADIOLIGAND; REBOXETINE; UNCLASSIFIED DRUG;

EID: 80052895269     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2011.36.8.1633941     Document Type: Review
Times cited : (6)

References (133)
  • 1
    • 33745050401 scopus 로고    scopus 로고
    • Using positron emission tomography to facilitate CNS drug development
    • Lee, C.M., Farde, L. Using positron emission tomography to facilitate CNS drug development. Trends Pharmacol Sci 2006, 27(6): 310-6.
    • (2006) Trends Pharmacol Sci , vol.27 , Issue.6 , pp. 310-316
    • Lee, C.M.1    Farde, L.2
  • 2
    • 57649136969 scopus 로고    scopus 로고
    • The role of imaging in proof of concept for CNS drug discovery and development
    • Wong, D.F., Tauscher, J., Grunder, G. The role of imaging in proof of concept for CNS drug discovery and development. Neuropsychopharmacology 2009, 34(1): 187-203.
    • (2009) Neuropsychopharmacology , vol.34 , Issue.1 , pp. 187-203
    • Wong, D.F.1    Tauscher, J.2    Grunder, G.3
  • 3
    • 0035001109 scopus 로고    scopus 로고
    • An introduction to PET and SPECT neuroreceptor quantification models
    • Ichise, M., Meyer, J.H., Yonekura, Y. An introduction to PET and SPECT neuroreceptor quantification models. J Nucl Med 2001, 42(5): 755-63.
    • (2001) J Nucl Med , vol.42 , Issue.5 , pp. 755-763
    • Ichise, M.1    Meyer, J.H.2    Yonekura, Y.3
  • 4
    • 34547846251 scopus 로고    scopus 로고
    • Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    • Innis, R.B., Cunningham, V.J., Delforge, J. et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab 2007, 27(9): 1533-9.
    • (2007) J Cereb Blood Flow Metab , vol.27 , Issue.9 , pp. 1533-1539
    • Innis, R.B.1    Cunningham, V.J.2    Delforge, J.3
  • 5
    • 1642293724 scopus 로고    scopus 로고
    • Mechanism of action of methylphenidate: Insights from PET imaging studies
    • Volkow, N.D., Fowler, J.S., Wang, G., Ding, Y., Gatley, S.J. Mechanism of action of methylphenidate: Insights from PET imaging studies. J Atten Disord 2002, 6(Suppl. 1): S31-43.
    • (2002) J Atten Disord , vol.6 , Issue.SUPPL. 1
    • Volkow, N.D.1    Fowler, J.S.2    Wang, G.3    Ding, Y.4    Gatley, S.J.5
  • 6
    • 0031660871 scopus 로고    scopus 로고
    • Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate
    • Volkow, N.D., Wang, G.J., Fowler, J.S. et al. Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate. Am J Psychiatry 1998, 155(10): 1325-31.
    • (1998) Am J Psychiatry , vol.155 , Issue.10 , pp. 1325-1331
    • Volkow, N.D.1    Wang, G.J.2    Fowler, J.S.3
  • 7
    • 33749370552 scopus 로고    scopus 로고
    • Unique roles of SPET brain imaging in clinical and research studies. Lessons from Parkinson's disease research
    • Seibyl, J., Jennings, D., Tabamo, R., Marek, K. Unique roles of SPET brain imaging in clinical and research studies. Lessons from Parkinson's disease research. Q J Nucl Med Mol Imaging 2005, 49(2): 215-21.
    • (2005) Q J Nucl Med Mol Imaging , vol.49 , Issue.2 , pp. 215-221
    • Seibyl, J.1    Jennings, D.2    Tabamo, R.3    Marek, K.4
  • 8
    • 47149108159 scopus 로고    scopus 로고
    • PE2I: A radiopharmaceutical for in vivo exploration of the dopamine transporter
    • Emond, P., Guilloteau, D., Chalon, S. PE2I: A radiopharmaceutical for in vivo exploration of the dopamine transporter. CNS Neurosci Ther 2008, 14(1): 47-64.
    • (2008) CNS Neurosci Ther , vol.14 , Issue.1 , pp. 47-64
    • Emond, P.1    Guilloteau, D.2    Chalon, S.3
  • 9
    • 0033786712 scopus 로고    scopus 로고
    • PET studies of brain monoamine transporters
    • Laakso, A., Hietala, J. PET studies of brain monoamine transporters. Curr Pharm Des 2000, 6(16): 1611-23.
    • (2000) Curr Pharm des , vol.6 , Issue.16 , pp. 1611-1623
    • Laakso, A.1    Hietala, J.2
  • 15
    • 16944362115 scopus 로고    scopus 로고
    • Reduced levels of norepinephrine transporters in the locus coeruleus in major depression
    • Klimek, V., Stockmeier, C., Overholser, J., Meltzer, H.Y., Kalka, S., Dilley, G., Ordway, G.A. Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. J Neurosci 1997, 17(21): 8451-8.
    • (1997) J Neurosci , vol.17 , Issue.21 , pp. 8451-8458
    • Klimek, V.1    Stockmeier, C.2    Overholser, J.3    Meltzer, H.Y.4    Kalka, S.5    Dilley, G.6    Ordway, G.A.7
  • 17
    • 61849185675 scopus 로고    scopus 로고
    • Norepinephrine and stimulant addiction
    • Sofuoglu, M., Sewell, R. A. Norepinephrine and stimulant addiction. Addict Biol 2009, 14(2): 119-29.
    • (2009) Addict Biol , vol.14 , Issue.2 , pp. 119-129
    • Sofuoglu, M.1    Sewell, R.A.2
  • 18
    • 79551686302 scopus 로고    scopus 로고
    • Depression and antidepressants: Insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters
    • Haenisch, B., Bonisch, H. Depression and antidepressants: Insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters. Pharmacol Ther 2011, 129(3): 352-68.
    • (2011) Pharmacol Ther , vol.129 , Issue.3 , pp. 352-368
    • Haenisch, B.1    Bonisch, H.2
  • 19
    • 0033915420 scopus 로고    scopus 로고
    • Mice lacking the norepinephrine transporter are supersensitive to psychostimulants
    • Xu, F., Gainetdinov, R.R., Wetsel, W.C. et al. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nat Neurosci 2000, 3(5): 465-71.
    • (2000) Nat Neurosci , vol.3 , Issue.5 , pp. 465-471
    • Xu, F.1    Gainetdinov, R.R.2    Wetsel, W.C.3
  • 20
    • 0035997057 scopus 로고    scopus 로고
    • Behavioral responses to social stress in noradrenaline transporter knockout mice: Effects on social behavior and depression
    • Haller, J., Bakos, N., Rodriguiz, R.M., Caron, M.G., Wetsel, W.C., Liposits, Z. Behavioral responses to social stress in noradrenaline transporter knockout mice: Effects on social behavior and depression. Brain Res Bull 2002, 58(3): 279-84.
    • (2002) Brain Res Bull , vol.58 , Issue.3 , pp. 279-284
    • Haller, J.1    Bakos, N.2    Rodriguiz, R.M.3    Caron, M.G.4    Wetsel, W.C.5    Liposits, Z.6
  • 21
    • 33749824386 scopus 로고    scopus 로고
    • PET imaging of norepinephrine transporters
    • Ding, Y.S., Lin, K.S., Logan, J. PET imaging of norepinephrine transporters. Curr Pharm Des 2006, 12(30): 3831-45.
    • (2006) Curr Pharm des , vol.12 , Issue.30 , pp. 3831-3845
    • Ding, Y.S.1    Lin, K.S.2    Logan, J.3
  • 22
    • 33845287689 scopus 로고    scopus 로고
    • 11C-labelled (R)-OHDMI and CFMME and their evaluation as candidate radioligands for imaging central norepinephrine transporters with PET
    • 11C-labelled (R)-OHDMI and CFMME and their evaluation as candidate radioligands for imaging central norepinephrine transporters with PET. Bioorg Med Chem 2007, 15(2): 616-25.
    • (2007) Bioorg Med Chem , vol.15 , Issue.2 , pp. 616-625
    • Schou, M.1    Pike, V.W.2    Sovago, J.3
  • 23
    • 68449097096 scopus 로고    scopus 로고
    • Fluorine-18 radiolabeled PET tracers for imaging monoamine transporters: Dopamine, serotonin, and norepinephrine
    • Stehouwer, J.S., Goodman, M.M. Fluorine-18 radiolabeled PET tracers for imaging monoamine transporters: Dopamine, serotonin, and norepinephrine. PET Clin 2009, 4(1): 101-28.
    • (2009) PET Clin , vol.4 , Issue.1 , pp. 101-128
    • Stehouwer, J.S.1    Goodman, M.M.2
  • 25
    • 15244360828 scopus 로고    scopus 로고
    • 3H]MeNER to norepinephrine transporters
    • 3H]MeNER to norepinephrine transporters. Synapse 2005, 56(2): 100-4.
    • (2005) Synapse , vol.56 , Issue.2 , pp. 100-104
    • Ghose, S.1    Fujita, M.2    Morrison, P.3
  • 26
    • 20744446933 scopus 로고    scopus 로고
    • Modeling and analysis of PET studies with norepinephrine transporter ligands: The search for a reference region
    • Logan, J., Ding, Y.S., Lin, K.S., Pareto, D., Fowler, J., Biegon, A. Modeling and analysis of PET studies with norepinephrine transporter ligands: The search for a reference region. Nucl Med Biol 2005, 32(5): 531-42.
    • (2005) Nucl Med Biol , vol.32 , Issue.5 , pp. 531-542
    • Logan, J.1    Ding, Y.S.2    Lin, K.S.3    Pareto, D.4    Fowler, J.5    Biegon, A.6
  • 29
    • 34247634689 scopus 로고    scopus 로고
    • 11C]MRB as a prospective PET ligand for imaging the norepinephrine transporter
    • 11C]MRB as a prospective PET ligand for imaging the norepinephrine transporter. Eur J Nucl Med Mol Imaging 2007, 34(5): 688-93.
    • (2007) Eur J Nucl Med Mol Imaging , vol.34 , Issue.5 , pp. 688-693
    • Severance, A.J.1    Milak, M.S.2    Kumar, J.S.3
  • 30
    • 34547851802 scopus 로고    scopus 로고
    • 11C]O-methyl reboxetine and PET: Problems and progress
    • 11C]O-methyl reboxetine and PET: Problems and progress. Nucl Med Biol 2007, 34(6): 667-79.
    • (2007) Nucl Med Biol , vol.34 , Issue.6 , pp. 667-679
    • Logan, J.1    Wang, G.J.2    Telang, F.3
  • 32
    • 77957899507 scopus 로고    scopus 로고
    • Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo
    • Hannestad, J., Gallezot, J.D., Planeta-Wilson, B. et al. Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo. Biol Psychiatry 2010, 68(9): 854-60.
    • (2010) Biol Psychiatry , vol.68 , Issue.9 , pp. 854-860
    • Hannestad, J.1    Gallezot, J.D.2    Planeta-Wilson, B.3
  • 33
    • 79953045711 scopus 로고    scopus 로고
    • 11C]MRB for assessment of occupancy of norepinephrine transporters: Studies with atomoxetine in non-human primates
    • 11C]MRB for assessment of occupancy of norepinephrine transporters: Studies with atomoxetine in non-human primates. Neuroimage 2011, 56(1): 268-79.
    • (2011) Neuroimage , vol.56 , Issue.1 , pp. 268-279
    • Gallezot, J.D.1    Weinzimmer, D.2    Nabulsi, N.3
  • 36
    • 19244366615 scopus 로고    scopus 로고
    • PET evaluation of novel radiofluorinated reboxetine analogs as norepinephrine transporter probes in the monkey brain
    • Schou, M., Halldin, C., Sovago, J. et al. PET evaluation of novel radiofluorinated reboxetine analogs as norepinephrine transporter probes in the monkey brain. Synapse 2004, 53(2): 57-67.
    • (2004) Synapse , vol.53 , Issue.2 , pp. 57-67
    • Schou, M.1    Halldin, C.2    Sovago, J.3
  • 39
    • 79959922915 scopus 로고    scopus 로고
    • NET occupancy by clomipramine and its active metabolite, desmethylclomipramine, in nonhuman primates in vivo
    • Berl
    • Takano, A., Nag, S., Gulyas, B., Halldin, C., Farde, L. NET occupancy by clomipramine and its active metabolite, desmethylclomipramine, in nonhuman primates in vivo. Psychopharmacology (Berl) 2011, 216(2): 279-86.
    • (2011) Psychopharmacology , vol.216 , Issue.2 , pp. 279-286
    • Takano, A.1    Nag, S.2    Gulyas, B.3    Halldin, C.4    Farde, L.5
  • 41
    • 36349008186 scopus 로고    scopus 로고
    • Development of radioligands for imaging of brain norepinephrine transporters in vivo with positron emission tomography
    • Schou, M., Pike, V.W., Halldin, C. Development of radioligands for imaging of brain norepinephrine transporters in vivo with positron emission tomography. Curr Top Med Chem 2007, 7(18): 1806-16.
    • (2007) Curr Top Med Chem , vol.7 , Issue.18 , pp. 1806-1816
    • Schou, M.1    Pike, V.W.2    Halldin, C.3
  • 42
    • 33646446842 scopus 로고
    • 11C] nisoxetine, a norepinephrine uptake inhibitor
    • 11C]nisoxetine, a norepinephrine uptake inhibitor. Int J Rad Appl Instrum B 1989, 16(8): 771-4.
    • (1989) Int J Rad Appl Instrum B , vol.16 , Issue.8 , pp. 771-774
    • Haka, M.S.1    Kilbourn, M.R.2
  • 43
    • 77951594735 scopus 로고    scopus 로고
    • (R)-NMethyl- 3-(3′-[F]fluoropropyl)phenoxy-3-phenylpropanamine (F-MFP3) as a potential PET imaging agent for norepinephrine transporter
    • Nguyen, V.L., Pichika, R., Bhakta, P.H., Kant, R., Mukherjee, J. (R)-NMethyl- 3-(3′-[F]fluoropropyl)phenoxy)-3-phenylpropanamine (F-MFP3) as a potential PET imaging agent for norepinephrine transporter. J Labelled Compd Radiopharm 2010, 53(4): 172-7.
    • (2010) J Labelled Compd Radiopharm , vol.53 , Issue.4 , pp. 172-177
    • Nguyen, V.L.1    Pichika, R.2    Bhakta, P.H.3    Kant, R.4    Mukherjee, J.5
  • 44
    • 33747103205 scopus 로고    scopus 로고
    • Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors
    • Musachio, J.L., Hong, J., Ichise, M. et al. Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors. Bioorg Med Chem Lett 2006, 16(12): 3101-4.
    • (2006) Bioorg Med Chem Lett , vol.16 , Issue.12 , pp. 3101-3104
    • Musachio, J.L.1    Hong, J.2    Ichise, M.3
  • 45
    • 3042789525 scopus 로고    scopus 로고
    • 11C]talsupram: Candidate PET ligands for the norepinephrine transporter
    • 11C]talsupram: Candidate PET ligands for the norepinephrine transporter. Nucl Med Biol 2004, 31(6): 705-18.
    • (2004) Nucl Med Biol , vol.31 , Issue.6 , pp. 705-718
    • McConathy, J.1    Owens, M.J.2    Kilts, C.D.3
  • 47
    • 0026611590 scopus 로고
    • 3H]nisoxetine binding to uptake sites for norepinephrine in the locus coeruleus of humans
    • 3H] nisoxetine binding to uptake sites for norepinephrine in the locus coeruleus of humans. Brain Res 1992, 583(1-2): 312-5.
    • (1992) Brain Res , vol.583 , Issue.1-2 , pp. 312-315
    • Tejani-Butt, S.M.1    Ordway, G.A.2
  • 48
    • 0026610297 scopus 로고
    • 3H]Nisoxetine: A radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding
    • 3H]Nisoxetine: A radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding. J Pharmacol Exp Ther 1992, 260(1): 427-36.
    • (1992) J Pharmacol Exp Ther , vol.260 , Issue.1 , pp. 427-436
    • Tejani-Butt, S.M.1
  • 49
    • 0027162344 scopus 로고
    • 3H]tomoxetine, an enantiomerically pure ligand for norepinephrine reuptake sites
    • 3H]tomoxetine, an enantiomerically pure ligand for norepinephrine reuptake sites. Neurosci Lett 1993, 157(2): 203-6.
    • (1993) Neurosci Lett , vol.157 , Issue.2 , pp. 203-206
    • Gehlert, D.R.1    Gackenheimer, S.L.2    Robertson, D.W.3
  • 50
    • 0026575632 scopus 로고
    • Positron emission tomography - Examination of chemical transmission in the living human brain. Development of radioligands
    • Farde, L., Hall, H. Positron emission tomography - Examination of chemical transmission in the living human brain. Development of radioligands. Arzneimittelforschung 1992, 42(2A): 260-4.
    • (1992) Arzneimittelforschung , vol.42 , Issue.2 A , pp. 260-264
    • Farde, L.1    Hall, H.2
  • 52
    • 0034018859 scopus 로고    scopus 로고
    • Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review
    • Laruelle, M. Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review. J Cereb Blood Flow Metab 2000, 20(3): 423-51.
    • (2000) J Cereb Blood Flow Metab , vol.20 , Issue.3 , pp. 423-451
    • Laruelle, M.1
  • 53
    • 0027407724 scopus 로고
    • In vivo assessment of basal and drug-induced dopamine release in cortical and subcortical regions of the anesthetized primate
    • Moghaddam, B., Berridge, C.W., Goldman-Rakic, P.S., Bunney, B.S., Roth, R.H. In vivo assessment of basal and drug-induced dopamine release in cortical and subcortical regions of the anesthetized primate. Synapse 1993, 13(3): 215-22.
    • (1993) Synapse , vol.13 , Issue.3 , pp. 215-222
    • Moghaddam, B.1    Berridge, C.W.2    Goldman-Rakic, P.S.3    Bunney, B.S.4    Roth, R.H.5
  • 54
    • 0028208964 scopus 로고
    • Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey: An in vivo microdialysis study
    • Saunders, R.C., Kolachana, B.S., Weinberger, D.R. Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey: An in vivo microdialysis study. Exp Brain Res 1994, 98(1): 44-52.
    • (1994) Exp Brain Res , vol.98 , Issue.1 , pp. 44-52
    • Saunders, R.C.1    Kolachana, B.S.2    Weinberger, D.R.3
  • 55
    • 0031030271 scopus 로고    scopus 로고
    • Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates
    • Laruelle, M., Iyerm R.N., al-Tikritim M.S. et al. Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates. Synapse 1997, 25(1): 1-14.
    • (1997) Synapse , vol.25 , Issue.1 , pp. 1-14
    • Laruelle, M.1    Iyerm, R.N.2    Al-Tikritim, M.S.3
  • 56
    • 12644293806 scopus 로고    scopus 로고
    • Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method
    • Breier, A., Su, T.P., Saunders, R. et al. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method. Proc Natl Acad Sci U S A 1997, 94(6): 2569-74.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.6 , pp. 2569-2574
    • Breier, A.1    Su, T.P.2    Saunders, R.3
  • 57
    • 60849098734 scopus 로고    scopus 로고
    • Neuroimaging and physiological evidence for involvement of glutamatergic transmission in regulation of the striatal dopaminergic system
    • Tokunaga, M., Seneca, N., Shin, R.M. et al. Neuroimaging and physiological evidence for involvement of glutamatergic transmission in regulation of the striatal dopaminergic system. J Neurosci 2009, 29(6): 1887-96.
    • (2009) J Neurosci , vol.29 , Issue.6 , pp. 1887-1896
    • Tokunaga, M.1    Seneca, N.2    Shin, R.M.3
  • 58
    • 0021132749 scopus 로고
    • Agonist interactions with dopamine receptors: Focus on radioligand-binding studies
    • Creese, I., Sibley, D.R., Leff, S.E. Agonist interactions with dopamine receptors: Focus on radioligand-binding studies. Fed Proc 1984, 43(13): 2779-84.
    • (1984) Fed Proc , vol.43 , Issue.13 , pp. 2779-2784
    • Creese, I.1    Sibley, D.R.2    Leff, S.E.3
  • 59
    • 0022414990 scopus 로고
    • The functional state of the dopamine receptor in the anterior pituitary is in the high affinity form
    • George, S.R., Watanabe, M., Di Paolo, T., Falardeau, P., Labrie, F., Seeman, P. The functional state of the dopamine receptor in the anterior pituitary is in the high affinity form. Endocrinology 1985, 117(2): 690-7.
    • (1985) Endocrinology , vol.117 , Issue.2 , pp. 690-697
    • George, S.R.1    Watanabe, M.2    Di Paolo, T.3    Falardeau, P.4    Labrie, F.5    Seeman, P.6
  • 60
    • 0022271046 scopus 로고
    • 2 receptor binding sites for agonists. A tetrahedral model
    • 2 receptor binding sites for agonists. A tetrahedral model. Mol Pharmacol 1985, 28(5): 391-9.
    • (1985) Mol Pharmacol , vol.28 , Issue.5 , pp. 391-399
    • Seeman, P.1    Watanabe, M.2    Grigoriadis, D.3
  • 61
    • 0020641659 scopus 로고
    • Dopamine receptor binding on intact cells. Absence of a high-affinity agonist-receptor binding state
    • Sibley, D.R., Mahan, L.C., Creese, I. Dopamine receptor binding on intact cells. Absence of a high-affinity agonist-receptor binding state. Mol Pharmacol 1983, 23(2): 295-302.
    • (1983) Mol Pharmacol , vol.23 , Issue.2 , pp. 295-302
    • Sibley, D.R.1    Mahan, L.C.2    Creese, I.3
  • 64
    • 20444379220 scopus 로고    scopus 로고
    • 2 high-affinity state with positron emission tomography
    • 2 high-affinity state with positron emission tomography. J Med Chem 2005, 48(12): 4153-60.
    • (2005) J Med Chem , vol.48 , Issue.12 , pp. 4153-4160
    • Wilson, A.A.1    McCormick, P.2    Kapur, S.3
  • 65
    • 33646078787 scopus 로고    scopus 로고
    • 2 receptors in vivo using positron emission tomography
    • 2 receptors in vivo using positron emission tomography. J Neurochem 2006, 97(4): 1089-103.
    • (2006) J Neurochem , vol.97 , Issue.4 , pp. 1089-1103
    • Ginovart, N.1    Galineau, L.2    Willeit, M.3
  • 68
    • 77951088919 scopus 로고    scopus 로고
    • 11C]raclopride to measure amphetamine-induced dopamine release in the human striatum
    • 11C]raclopride to measure amphetamine-induced dopamine release in the human striatum. J Pharmacol Exp Ther 2010, 333(2): 533-9.
    • (2010) J Pharmacol Exp Ther , vol.333 , Issue.2 , pp. 533-539
    • Narendran, R.1    Mason, N.S.2    Laymon, C.M.3
  • 70
    • 0029787944 scopus 로고    scopus 로고
    • Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects
    • Laruelle, M., Abi-Dargham, A., van Dyck, C.H. et al. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc Natl Acad Sci U S A 1996, 93(17): 9235-40.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.17 , pp. 9235-9240
    • Laruelle, M.1    Abi-Dargham, A.2    Van Dyck, C.H.3
  • 71
    • 77950858637 scopus 로고    scopus 로고
    • Microglia in neurodegenerative disease
    • Perry, V.H., Nicoll, J.A., Holmes, C. Microglia in neurodegenerative disease. Nat Rev Neurol 2010, 6(4): 193-201.
    • (2010) Nat Rev Neurol , vol.6 , Issue.4 , pp. 193-201
    • Perry, V.H.1    Nicoll, J.A.2    Holmes, C.3
  • 72
    • 78149322599 scopus 로고    scopus 로고
    • Changing face of microglia
    • Graeber, M.B. Changing face of microglia. Science 2010, 330(6005): 783-8.
    • (2010) Science , vol.330 , Issue.6005 , pp. 783-788
    • Graeber, M.B.1
  • 74
    • 33746035655 scopus 로고    scopus 로고
    • Translocator protein (18 kDa): New nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function
    • Papadopoulos, V., Baraldi, M., Guilarte, T.R. et al. Translocator protein (18 kDa): New nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci 2006, 27(8): 402-9.
    • (2006) Trends Pharmacol Sci , vol.27 , Issue.8 , pp. 402-409
    • Papadopoulos, V.1    Baraldi, M.2    Guilarte, T.R.3
  • 75
    • 65349120620 scopus 로고    scopus 로고
    • Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain
    • Cosenza-Nashat, M., Zhao, M.L., Suh, H.S., Morgan, J., Natividad, R., Morgello, S., Lee, S.C. Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain. Neuropathol Appl Neurobiol 2009, 35(3): 306-28.
    • (2009) Neuropathol Appl Neurobiol , vol.35 , Issue.3 , pp. 306-328
    • Cosenza-Nashat, M.1    Zhao, M.L.2    Suh, H.S.3    Morgan, J.4    Natividad, R.5    Morgello, S.6    Lee, S.C.7
  • 76
    • 20144384091 scopus 로고    scopus 로고
    • Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: A correlative study
    • Versijpt, J., Debruyne, J.C., Van Laere, K.J. et al. Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: A correlative study. Mult Scler 2005, 11(2): 127-34.
    • (2005) Mult Scler , vol.11 , Issue.2 , pp. 127-134
    • Versijpt, J.1    Debruyne, J.C.2    Van Laere, K.J.3
  • 77
    • 0033768486 scopus 로고    scopus 로고
    • The peripheral benzodiazepine binding site in the brain in multiple sclerosis: Quantitative in vivo imaging of microglia as a measure of disease activity
    • Banati, R.B., Newcombe, J., Gunn, R.N. et al. The peripheral benzodiazepine binding site in the brain in multiple sclerosis: Quantitative in vivo imaging of microglia as a measure of disease activity. Brain 2000, 123(Pt. 11): 2321-37.
    • (2000) Brain , vol.123 , Issue.PART 11 , pp. 2321-2337
    • Banati, R.B.1    Newcombe, J.2    Gunn, R.N.3
  • 78
    • 46849086547 scopus 로고    scopus 로고
    • 18F]pyrazolo[1,5- A]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography
    • 18F]pyrazolo[1,5- a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography. J Med Chem 2008, 51(13): 3700-12.
    • (2008) J Med Chem , vol.51 , Issue.13 , pp. 3700-3712
    • Fookes, C.J.1    Pham, T.Q.2    Mattner, F.3
  • 79
    • 37849018674 scopus 로고    scopus 로고
    • 11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors
    • 11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors. Neuroimage 2008, 39(3): 1289-98.
    • (2008) Neuroimage , vol.39 , Issue.3 , pp. 1289-1298
    • Imaizumi, M.1    Briard, E.2    Zoghbi, S.S.3
  • 80
    • 68249150559 scopus 로고    scopus 로고
    • 11C]DPA-713, a novel TSPO PET ligand, in humans
    • 11C]DPA-713, a novel TSPO PET ligand, in humans. J Nucl Med 2009, 50(8): 1276-82.
    • (2009) J Nucl Med , vol.50 , Issue.8 , pp. 1276-1282
    • Endres, C.J.1    Pomper, M.G.2    James, M.3
  • 82
    • 0034063730 scopus 로고    scopus 로고
    • Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity
    • Kuhlmann, A.C., Guilarte, T.R. Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity. J Neurochem 2000, 74(4): 1694-704.
    • (2000) J Neurochem , vol.74 , Issue.4 , pp. 1694-1704
    • Kuhlmann, A.C.1    Guilarte, T.R.2
  • 83
    • 34250627649 scopus 로고    scopus 로고
    • Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor
    • Maeda, J., Higuchi, M., Inaji, M. et al. Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor. Brain Res 2007, 1157: 100-11.
    • (2007) Brain Res , vol.1157 , pp. 100-111
    • Maeda, J.1    Higuchi, M.2    Inaji, M.3
  • 84
    • 79960594561 scopus 로고    scopus 로고
    • Translocator protein PET imaging for glial activation in multiple sclerosis
    • Oh, U., Fujita, M., Ikonomidou, V.N. et al. Translocator protein PET imaging for glial activation in multiple sclerosis. J Neuroimmune Pharmacol 2011, 6(3): 354-61.
    • (2011) J Neuroimmune Pharmacol , vol.6 , Issue.3 , pp. 354-361
    • Oh, U.1    Fujita, M.2    Ikonomidou, V.N.3
  • 85
    • 70350455478 scopus 로고    scopus 로고
    • Stroke incidentally identified using improved positron emission tomography for microglial activation
    • Kreisl, W.C., Mbeo, G., Fujita, M., Zoghbi, S.S., Pike, V.W., Innis, R.B., McArthur, J.C. Stroke incidentally identified using improved positron emission tomography for microglial activation. Arch Neurol 2009, 66(10): 1288-9.
    • (2009) Arch Neurol , vol.66 , Issue.10 , pp. 1288-1289
    • Kreisl, W.C.1    Mbeo, G.2    Fujita, M.3    Zoghbi, S.S.4    Pike, V.W.5    Innis, R.B.6    McArthur, J.C.7
  • 86
    • 73749087636 scopus 로고    scopus 로고
    • 11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker
    • 11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker. Neuroimage 2010, 49(4): 2924-32.
    • (2010) Neuroimage , vol.49 , Issue.4 , pp. 2924-2932
    • Kreisl, W.C.1    Fujita, M.2    Fujimura, Y.3
  • 87
    • 77956263860 scopus 로고    scopus 로고
    • 3H]PBR28 in human brain: Implications for TSPO PET imaging of neuroinflammation
    • 3H]PBR28 in human brain: Implications for TSPO PET imaging of neuroinflammation. J Cereb Blood Flow Metab 2010, 30(9): 1608-18.
    • (2010) J Cereb Blood Flow Metab , vol.30 , Issue.9 , pp. 1608-1618
    • Owen, D.R.1    Howell, O.W.2    Tang, S.P.3
  • 88
    • 79851473610 scopus 로고    scopus 로고
    • Mixed-affinity binding in humans with 18-kDa translocator protein ligands
    • Owen, D.R., Gunn, R.N., Rabiner, E.A. et al. Mixed-affinity binding in humans with 18-kDa translocator protein ligands. J Nucl Med 2011, 52(1): 24-32.
    • (2011) J Nucl Med , vol.52 , Issue.1 , pp. 24-32
    • Owen, D.R.1    Gunn, R.N.2    Rabiner, E.A.3
  • 89
    • 0344393516 scopus 로고    scopus 로고
    • Regulation of macrophage activation
    • Ma, J., Chen, T., Mandelin, J. et al. Regulation of macrophage activation. Cell Mol Life Sci 2003, 60(11): 2334-46.
    • (2003) Cell Mol Life Sci , vol.60 , Issue.11 , pp. 2334-2346
    • Ma, J.1    Chen, T.2    Mandelin, J.3
  • 91
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: Unique stimuli, specialized responses
    • Ransohoff, R.M. Perry, V.H. Microglial physiology: Unique stimuli, specialized responses. Annu Rev Immunol 2009, 27: 119-45.
    • (2009) Annu Rev Immunol , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 92
    • 0028399655 scopus 로고
    • Astrocytes: Form, functions, and roles in disease
    • Montgomery, D L. Astrocytes: Form, functions, and roles in disease. Vet Pathol 1994, 31(2): 145-67.
    • (1994) Vet Pathol , vol.31 , Issue.2 , pp. 145-167
    • Montgomery, D.L.1
  • 93
    • 77649189116 scopus 로고    scopus 로고
    • Astrocytes: Biology and pathology
    • Sofroniew, M.V.,Vinters, H.V. Astrocytes: Biology and pathology. Acta Neuropathol 2010, 119(1): 7-35.
    • (2010) Acta Neuropathol , vol.119 , Issue.1 , pp. 7-35
    • Sofroniew, M.V.1    Vinters, H.V.2
  • 94
    • 33846304662 scopus 로고    scopus 로고
    • The role of astrocytes in the physiology and pathology of the central nervous system
    • Wars
    • Markiewicz, I., Lukomska, B. The role of astrocytes in the physiology and pathology of the central nervous system. Acta Neurobiol Exp (Wars) 2006, 66(4): 343-58.
    • (2006) Acta Neurobiol Exp , vol.66 , Issue.4 , pp. 343-358
    • Markiewicz, I.1    Lukomska, B.2
  • 95
    • 70449678738 scopus 로고    scopus 로고
    • Molecular dissection of reactive astrogliosis and glial scar formation
    • Sofroniew, M.V. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci 2009, 32(12): 638-47.
    • (2009) Trends Neurosci , vol.32 , Issue.12 , pp. 638-647
    • Sofroniew, M.V.1
  • 96
    • 77957090798 scopus 로고    scopus 로고
    • Reactive astrocytes as therapeutic targets for CNS disorders
    • Hamby, M.E., Sofroniew, M.V. Reactive astrocytes as therapeutic targets for CNS disorders. Neurotherapeutics 2010, 7(4): 494-506.
    • (2010) Neurotherapeutics , vol.7 , Issue.4 , pp. 494-506
    • Hamby, M.E.1    Sofroniew, M.V.2
  • 97
    • 77953760524 scopus 로고    scopus 로고
    • 11C]MeSIMPY to b-amyloid plaques in patients with Alzheimer's disease
    • 11C]MeSIMPY to b-amyloid plaques in patients with Alzheimer's disease. Curr Radiopharm 2009, 2(2): 129-36.
    • (2009) Curr Radiopharm , vol.2 , Issue.2 , pp. 129-136
    • Seneca, N.1    Cai, L.2    Liow, J.S.3
  • 99
    • 0037475148 scopus 로고    scopus 로고
    • 18F]fluoroethyl)(methyl)amino]-2-naphthyl] ethylidene)malono nitrile
    • 18F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malono nitrile. Neuroscience 2003, 117(3): 723-30.
    • (2003) Neuroscience , vol.117 , Issue.3 , pp. 723-730
    • Agdeppa, E.D.1    Kepe, V.2    Petri, A.3
  • 100
    • 10744232413 scopus 로고    scopus 로고
    • Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B
    • Klunk, W.E., Engler, H., Nordberg, A. et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B. Ann Neurol 2004, 55(3): 306-19.
    • (2004) Ann Neurol , vol.55 , Issue.3 , pp. 306-319
    • Klunk, W.E.1    Engler, H.2    Nordberg, A.3
  • 101
    • 34248579112 scopus 로고    scopus 로고
    • 2-(2-[2-Dimethylaminothiazol- 5-yl]ethenyl)-6- (2-[fluoro]ethoxy) benzoxazole: A novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients
    • Kudo, Y., Okamura, N., Furumoto, S. et al. 2-(2-[2-Dimethylaminothiazol- 5-yl]ethenyl)-6- (2-[fluoro]ethoxy)benzoxazole: A novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients. J Nucl Med 2007, 48(4): 553-61.
    • (2007) J Nucl Med , vol.48 , Issue.4 , pp. 553-561
    • Kudo, Y.1    Okamura, N.2    Furumoto, S.3
  • 102
    • 77952552594 scopus 로고    scopus 로고
    • 18F]AV-45, a novel amyloid imaging agent - A pilot study
    • 18F]AV-45, a novel amyloid imaging agent - A pilot study. Nucl Med Biol 2010, 37(4): 497-508.
    • (2010) Nucl Med Biol , vol.37 , Issue.4 , pp. 497-508
    • Lin, K.J.1    Hsu, W.C.2    Hsiao, I.T.3
  • 104
    • 79960982332 scopus 로고    scopus 로고
    • Amyloid imaging as a surrogate marker in clinical trials in Alzheimer's disease
    • Scheinin Noora, M., Scheinin, M., Rinne, J.O. Amyloid imaging as a surrogate marker in clinical trials in Alzheimer's disease. Q J Nucl Med Mol Imaging 2011, 55(3): 265-79.
    • (2011) Q J Nucl Med Mol Imaging , vol.55 , Issue.3 , pp. 265-279
    • Scheinin Noora, M.1    Scheinin, M.2    Rinne, J.O.3
  • 105
    • 77955474351 scopus 로고    scopus 로고
    • The Alzheimer's disease neuroimaging initiative: Progress report and future plans
    • Weiner, M.W., Aisen, P.S., Jack, C.R. Jr. et al. The Alzheimer's disease neuroimaging initiative: Progress report and future plans. Alzheimers Dement 2010, 6(3): 202-11.
    • (2010) Alzheimers Dement , vol.6 , Issue.3 , pp. 202-211
    • Weiner, M.W.1    Aisen, P.S.2    Jack Jr., C.R.3
  • 107
    • 80052881236 scopus 로고    scopus 로고
    • PET amyloid imaging as a tool for early diagnosis and identifying patients at risk for progression to Alzheimer's disease
    • Pontecorvo, M.J., Mintun, M.A. PET amyloid imaging as a tool for early diagnosis and identifying patients at risk for progression to Alzheimer's disease. Alzheimers Res Ther 2011, 3(2): 11.
    • (2011) Alzheimers Res Ther , vol.3 , Issue.2 , pp. 11
    • Pontecorvo, M.J.1    Mintun, M.A.2
  • 108
    • 33749506795 scopus 로고    scopus 로고
    • Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
    • Engler, H., Forsberg, A., Almkvist, O. et al. Two-year follow-up of amyloid deposition in patients with Alzheimer's disease. Brain 2006, 129(Pt. 11): 2856-66.
    • (2006) Brain , vol.129 , Issue.PART 11 , pp. 2856-2866
    • Engler, H.1    Forsberg, A.2    Almkvist, O.3
  • 109
    • 70350164263 scopus 로고    scopus 로고
    • 11C]PIB uptake and brain volume in patients with Alzheimer disease and controls
    • 11C]PIB uptake and brain volume in patients with Alzheimer disease and controls. Neurology 2009, 73(15): 1186-92.
    • (2009) Neurology , vol.73 , Issue.15 , pp. 1186-1192
    • Scheinin, N.M.1    Aalto, S.2    Koikkalainen, J.3
  • 110
    • 79953177902 scopus 로고    scopus 로고
    • Amyloid PET imaging in patients with mild cognitive impairment: A 2-year follow-up study
    • Koivunen, J., Scheinin, N., Virta, J.R. et al. Amyloid PET imaging in patients with mild cognitive impairment: A 2-year follow-up study. Neurology 2011, 76(12): 1085-90.
    • (2011) Neurology , vol.76 , Issue.12 , pp. 1085-1090
    • Koivunen, J.1    Scheinin, N.2    Virta, J.R.3
  • 112
    • 77949300796 scopus 로고    scopus 로고
    • 11C]PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: A phase 2, double-blind, placebo-controlled, ascending-dose study
    • 11C]PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: A phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol 2010, 9(4): 363-72.
    • (2010) Lancet Neurol , vol.9 , Issue.4 , pp. 363-372
    • Rinne, J.O.1    Brooks, D.J.2    Rossor, M.N.3
  • 113
    • 33947198109 scopus 로고    scopus 로고
    • Molecular imaging with Pittsburgh compound B confirmed at autopsy: A case report
    • Bacskai, B.J., Frosch, M.P., Freeman, S.H. et al. Molecular imaging with Pittsburgh compound B confirmed at autopsy: A case report. Arch Neurol 2007, 64(3): 431-4.
    • (2007) Arch Neurol , vol.64 , Issue.3 , pp. 431-434
    • Bacskai, B.J.1    Frosch, M.P.2    Freeman, S.H.3
  • 114
    • 0142123057 scopus 로고    scopus 로고
    • Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice
    • Bacskai, B.J., Hickey, G.A., Skoch, J. et al. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice. Proc Natl Acad Sci U S A 2003, 100(21): 12462-7.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.21 , pp. 12462-12467
    • Bacskai, B.J.1    Hickey, G.A.2    Skoch, J.3
  • 115
    • 34948819200 scopus 로고    scopus 로고
    • Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    • Johnson, K.A., Gregas, M., Becker, J.A. et al. Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol 2007, 62(3): 229-34.
    • (2007) Ann Neurol , vol.62 , Issue.3 , pp. 229-234
    • Johnson, K.A.1    Gregas, M.2    Becker, J.A.3
  • 116
    • 78149492502 scopus 로고    scopus 로고
    • Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy
    • Dierksen, G.A., Skehan, M.E., Khan, M.A. et al. Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. Ann Neurol 2010, 68(4): 545-8.
    • (2010) Ann Neurol , vol.68 , Issue.4 , pp. 545-548
    • Dierksen, G.A.1    Skehan, M.E.2    Khan, M.A.3
  • 117
    • 57749117469 scopus 로고    scopus 로고
    • Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B
    • Greenberg, S.M., Grabowski, T., Gurol, M.E. et al. Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B. Ann Neurol 2008, 64(5): 587-91.
    • (2008) Ann Neurol , vol.64 , Issue.5 , pp. 587-591
    • Greenberg, S.M.1    Grabowski, T.2    Gurol, M.E.3
  • 118
    • 0021075136 scopus 로고
    • Cerebral amyloid angiopathy: Incidence and complications in the aging brain. II. The distribution of amyloid vascular changes
    • Vinters, H.V., Gilbert, J.J. Cerebral amyloid angiopathy: Incidence and complications in the aging brain. II. The distribution of amyloid vascular changes. Stroke 1983, 14(6): 924-8.
    • (1983) Stroke , vol.14 , Issue.6 , pp. 924-928
    • Vinters, H.V.1    Gilbert, J.J.2
  • 119
    • 34848885454 scopus 로고    scopus 로고
    • PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptide-related cerebral amyloidosis
    • Lockhart, A., Lamb, J.R., Osredkar, T. et al. PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptide-related cerebral amyloidosis. Brain 2007, 130(Pt. 10): 2607-15.
    • (2007) Brain , vol.130 , Issue.PART 10 , pp. 2607-2615
    • Lockhart, A.1    Lamb, J.R.2    Osredkar, T.3
  • 120
    • 66449103267 scopus 로고    scopus 로고
    • PET/MRI: The blended-modality choice of the future?
    • quiz 2-3
    • Bolus, N.E., George, R., Washington, J., Newcomer, B.R. PET/MRI: The blended-modality choice of the future? J Nucl Med Technol 2009, 37(2): 63-71; quiz 2-3.
    • (2009) J Nucl Med Technol , vol.37 , Issue.2 , pp. 63-71
    • Bolus, N.E.1    George, R.2    Washington, J.3    Newcomer, B.R.4
  • 121
    • 41849093686 scopus 로고    scopus 로고
    • Simultaneous PET-MRI: A new approach for functional and morphological imaging
    • Judenhofer, M.S., Wehrl, H.F., Newport, D.F. et al. Simultaneous PET-MRI: A new approach for functional and morphological imaging. Nat Med 2008, 14(4): 459-65.
    • (2008) Nat Med , vol.14 , Issue.4 , pp. 459-465
    • Judenhofer, M.S.1    Wehrl, H.F.2    Newport, D.F.3
  • 122
    • 77950366807 scopus 로고    scopus 로고
    • PET/MRI: Paving the way for the next generation of clinical multimodality imaging applications
    • Pichler, B.J., Kolb, A., Nagele, T., Schlemmer, H. P. PET/MRI: Paving the way for the next generation of clinical multimodality imaging applications. J Nucl Med 2010, 51(3): 333-6.
    • (2010) J Nucl Med , vol.51 , Issue.3 , pp. 333-336
    • Pichler, B.J.1    Kolb, A.2    Nagele, T.3    Schlemmer, H.P.4
  • 123
    • 79551684090 scopus 로고    scopus 로고
    • 11C]CURB: Evaluation of a novel radiotracer for imaging fatty acid amide hydrolase by positron emission tomography
    • 11C]CURB: Evaluation of a novel radiotracer for imaging fatty acid amide hydrolase by positron emission tomography. Nucl Med Biol 2011, 38(2): 247-53.
    • (2011) Nucl Med Biol , vol.38 , Issue.2 , pp. 247-253
    • Wilson, A.A.1    Garcia, A.2    Parkes, J.3    Houle, S.4    Tong, J.5    Vasdev, N.6
  • 124
    • 79955402431 scopus 로고    scopus 로고
    • Synthesis and evaluation of radioligands for imaging brain nociceptin/orphanin FQ peptide (NOP) receptors with positron emission tomography
    • Pike, V.W., Rash, K.S., Chen, Z. et al. Synthesis and evaluation of radioligands for imaging brain nociceptin/orphanin FQ peptide (NOP) receptors with positron emission tomography. J Med Chem 2011, 54(8): 2687-700.
    • (2011) J Med Chem , vol.54 , Issue.8 , pp. 2687-2700
    • Pike, V.W.1    Rash, K.S.2    Chen, Z.3
  • 125
    • 79955556415 scopus 로고    scopus 로고
    • 18F]fluoro-N- [4-[6-(isopropylamino)pyrimidin-4-yl]- 1,3-thiazol-2-yl]-N- methylbenzamide as a new positron emission tomography ligand for metabotropic glutamate receptor subtype 1
    • 18F]fluoro-N-[4-[6-(isopropylamino) pyrimidin-4-yl]- 1,3-thiazol-2-yl]-N- methylbenzamide as a new positron emission tomography ligand for metabotropic glutamate receptor subtype 1. Bioorg Med Chem Lett 2011, 21(10): 2998-3001.
    • (2011) Bioorg Med Chem Lett , vol.21 , Issue.10 , pp. 2998-3001
    • Yamasaki, T.1    Fujinaga, M.2    Yoshida, Y.3
  • 127
    • 78649996218 scopus 로고    scopus 로고
    • 18F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435
    • 18F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435. Synapse 2011, 65(2): 125-35.
    • (2011) Synapse , vol.65 , Issue.2 , pp. 125-135
    • Hostetler, E.D.1    Eng, W.2    Joshi, A.D.3
  • 130
    • 33745136077 scopus 로고    scopus 로고
    • Imaging of CNS myelin by positron-emission tomography
    • Stankoff, B., Wang, Y., Bottlaender, M. et al. Imaging of CNS myelin by positron-emission tomography. Proc Natl Acad Sci U S A 2006, 103(24): 9304-9.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.24 , pp. 9304-9309
    • Stankoff, B.1    Wang, Y.2    Bottlaender, M.3
  • 131
    • 78649449000 scopus 로고    scopus 로고
    • A novel PET marker for in vivo quantification of myelination
    • Wu, C., Wang, C., Popescu, D.C. et al. A novel PET marker for in vivo quantification of myelination. Bioorg Med Chem 2010, 18(24): 8592-9.
    • (2010) Bioorg Med Chem , vol.18 , Issue.24 , pp. 8592-8599
    • Wu, C.1    Wang, C.2    Popescu, D.C.3
  • 132
    • 79953787899 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of coumarin-based molecular probes for imaging of myelination
    • Wang, C., Wu, C., Zhu, J., Miller, R.H., Wang, Y. Design, synthesis, and evaluation of coumarin-based molecular probes for imaging of myelination. J Med Chem 2011, 54(7): 2331-40.
    • (2011) J Med Chem , vol.54 , Issue.7 , pp. 2331-2340
    • Wang, C.1    Wu, C.2    Zhu, J.3    Miller, R.H.4    Wang, Y.5
  • 133
    • 79953651513 scopus 로고    scopus 로고
    • 18F]THK523: A novel in vivo tau imaging ligand for Alzheimer's disease
    • 18F]THK523: A novel in vivo tau imaging ligand for Alzheimer's disease. Brain 2011, 134(Pt. 4): 1089-100.
    • (2011) Brain , vol.134 , Issue.PART 4 , pp. 1089-1100
    • Fodero-Tavoletti, M.T.1    Okamura, N.2    Furumoto, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.