In vivo assessment of [11C]MRB as a prospective PET ligand for imaging the norepinephrine transporter

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 34, Issue 5, 2007, Pages 688-693

  Severance, Alin J ^b   Milak, Matthew S ^a,b   Kumar, J S Dileep ^a,b   Prabhakaran, Jaya ^a   Majo, Vattoly J ^a   Simpson, Norman R ^a   Van Heertum, Ronald L ^a   Arango, Victoria ^a,b   Mann, J John ^a,b   Parsey, Ramin V ^a,b  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

Animal imaging; Brain receptors and neurotransmitters; Kinetic modelling; PET; Psychiatry

Indexed keywords

LIGAND; METHYLREBOXETINE C 11; NISOXETINE; NORADRENALIN TRANSPORTER; NORADRENALIN UPTAKE INHIBITOR; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; ADRENERGIC RECEPTOR AFFECTING AGENT; CARBON; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUOXETINE; MORPHOLINE DERIVATIVE; REBOXETINE; SEROTONIN TRANSPORTER;

ANIMAL EXPERIMENT; ARTICLE; BABOON; BINDING AFFINITY; BINDING KINETICS; CONTROLLED STUDY; DRUG TARGETING; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR IMAGING; NEUROBIOLOGY; NEUROPSYCHIATRY; NONHUMAN; PHARMACOLOGICAL BLOCKING; POSITRON EMISSION TOMOGRAPHY; PRIMATE; RELIABILITY; SENSITIVITY ANALYSIS; ANIMAL; DIAGNOSTIC IMAGING; IMAGE PROCESSING; INSTRUMENTATION; KINETICS; METABOLISM; METHODOLOGY; PAPIO; SENSITIVITY AND SPECIFICITY; TIME;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; CARBON RADIOISOTOPES; DIAGNOSTIC IMAGING; FLUOXETINE; IMAGE PROCESSING, COMPUTER-ASSISTED; KINETICS; LIGANDS; MORPHOLINES; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PAPIO; POSITRON-EMISSION TOMOGRAPHY; SENSITIVITY AND SPECIFICITY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TIME FACTORS;

EID: 34247634689     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-006-0312-2     Document Type: Article

References (14)

1. Brunswick DJ, Benmansour S, Tejani-Butt SM, Hauptmann M. Effects of high-dose methamphetamine on monoamine uptake sites in rat brain measured by quantitative autoradiography. Synapse 1992;11:287-93.
2. Logan J, Ding YS, Lin KS, Pareto D, Fowler J, Biegon A. Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region. Nucl Med Biol 2005;32:531-42.
3. 3H]nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding. J Pharmacol Exp Ther 1992;260:427-36.
4. Versteeg DH, Van Der Gugten J, De Jong W, Palkovits M. Regional concentrations of noradrenaline and dopamine in rat brain. Brain Res 1976;113:563-74.
5. 3H] Nisoxetine binding sites in the cat brain: an autoradiographic study. Neuroscience 1995;69:259-70.
6. Wilson AA, Johnson DP, Mozley D, Hussey D, Ginovart N, Nobrega J, et al. Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter. Nucl Med Biol 2003;30:85-92.
7. 11C]MeNER. Nucl Med Biol 2003;30:707-14.
8. 11C]oxaprotiline and [11C]lortalamine. J Neurochem 2005;94:337-51.
9. Prabhakaran J, Majo VJ, Mann JJ, Kumar JS. Chiral synthesis of (2S,3S)-2-(2-morpholin-2-yl-2-phenylmethoxy)phenol. Chirality 2004;16:168-73.
10. 11C]-DASB to the serotonin transporter in baboons: response to acute serotonin deficiency. Biol Psychiatry 2005;57:102-6.
11. Wong DT, Threlkeld PG, Best KL, Bymaster FP. A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. J Pharmacol Exp Ther 1982;222:61-5.
12. Parsey RV, Ogden RT, Mann JJ. Determination of volume of distribution using likelihood estimation in graphical analysis: elimination of estimation bias. J Cereb Blood Flow Metab 2003;23:1471-8.
13. Schroeder C, Adams F, Boschmann M, Tank J, Haertter S, Diedrich A, et al. Phenotypical evidence for a gender difference in cardiac norepinephrine transporter function. Am J Physiol Regul Integr Comp Physiol 2004;286:851-6.
14. 18F] FMeNER-D2. Psychopharmacology (Berl) 2006;188:119-27.