Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo

Biological Psychiatry

Volumn 68, Issue 9, 2010, Pages 854-860

  Hannestad, Jonas ^a   Gallezot, Jean Dominique ^a   Planeta Wilson, Beata ^a   Lin, Shu Fei ^a   Williams, Wendol A ^a   Van Dyck, Christopher H ^a   Malison, Robert T ^a   Carson, Richard E ^a   Ding, Yu Shin ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

11C methylreboxetine; attention deficit hyperactivity disorder; dopamine; methylphenidate; norepinephrine transporter; positron emission tomography

Indexed keywords

METHYLPHENIDATE; METHYLREBOXETINE C 11; NORADRENALIN TRANSPORTER; PLACEBO; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BRAIN REGION; CAPILLARY GAS CHROMATOGRAPHY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG TRANSPORT; FEMALE; HUMAN; IMAGE ANALYSIS; IMAGE RECONSTRUCTION; MALE; MASS SPECTROMETRY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; SINGLE BLIND PROCEDURE; THALAMUS;

ADULT; BRAIN; CENTRAL NERVOUS SYSTEM STIMULANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; METHYLPHENIDATE; MORPHOLINES; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY;

EID: 77957899507     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.06.017     Document Type: Article

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