New antifolates: Pharmacology and clinical applications

Oncologist

Volumn 1, Issue 1-2, 1996, Pages 68-81

  Takimoto, Chris H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

1843U89; AG337; Edatrexale; Lometrexol; LY231514; Methotrexate; Piritmim; Trimetrexate; ZD1694

Indexed keywords

EID: 0001845556     PISSN: 10837159     EISSN: None     Source Type: Journal    
DOI: 10.1634/theoncologist.1-1-68     Document Type: Article

References (12)

1. Farber S, Diamond L, Mercer R et al. Temporary remissions in acute leukemia in children produced by folic antagonist 4-amino-pteroyl-glutamic acid (aminopterin). N Engl J Med 1948;238:787-793.
2. Fleming GF, Schilsky RL. Antifolates: the next generation. Semin Oncol 1992;19:707-719.
3. Fleisher M. Antifolate analogs: mechanism of action, analytical methodology, and clinical efficacy. Ther Drug Monit 1993;15:521-526.
4. Takimoto CH, Allegra CJ. New antifolates in clinical development. Oncology 1995;9:649-660.
5. Allegra CJ. Antifolates. In: Chabner B, Collins J, eds. Cancer Chemotherapy: Principles & Practice. Philadelphia: Lippincott, 1990:110-153.
6. Fahre I, Fahre G, Goldman I. Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro. Cancer Res 1984;44:3190-3195.
7. Allegra C, Chabner B, Drake J et al. Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates. J Biol Chem 1985;260:9720-9726.
8. Allegra CJ, Drake JC, Jolivet J et al. Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates. Proc Natl Acad Sci USA 1985;82:4881-4885.
9. Allegra CJ, Fine RL, Drake JC et al. The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis. J Biol Chem 1986;261:6478-6485.
10. Allegra CJ, Hoang K, Yeh GC et al. Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate. J Biol Chem 1987;262:13520-13526.
11. Li WW, Lin JT, long WP et al. Mechanisms of natural resistance to antifolates in human soft tissue sarcomas. Cancer Res 1992;52:1434-1438.
12. Howell S, Mansfield S, Taetle R. Thymidine and hypoxantine requirements of normal and malignant cells for protection against methotrexate cytoxicity. Cancer Res 1981;41:945-949.