Herpes simplex virus type 1 in brain and risk of Alzheimer's disease

Lancet

Volumn 349, Issue 9047, 1997, Pages 241-244

  Itzhaki, Ruth F ^a   Lin, Woan Ru ^a   Shang, Dazhuang ^a   Wilcock, Gordon K ^b   Faragher, Brian ^c   Jamieson, Gordon A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b FRENCHAY HOSPITAL   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4; THYMIDINE KINASE;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; BRAIN; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FRONTAL LOBE; GENE FREQUENCY; HERPES; HERPES SIMPLEX VIRUS 1; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; LATENT PERIOD; MALE; MULTIPLE REGRESSION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECURRENT INFECTION; RISK; RISK FACTOR; TEMPORAL LOBE; VIRUS REACTIVATION;

EID: 0031023443     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(96)10149-5     Document Type: Article

References (26)

1. Ball M. Limbic predilection in Alzheimer's dementia: is reactivated herpes virus involved? Can J Neurol Sci 1982; 9: 303-06.
2. Itzhaki RF. Possible factors in the aetiology of Alzheimer's disease. Mol Neurobiol 1994; 9: 1-13.
3. Esiri MM. Viruses and Alzheimer's disease. J Neurol Neurosurg Psychiatr 1982; 45: 759.
4. Roberts G, Taylor G, Carter G, et al. Herpes simplex virus: a role in the aetiology of Alzheimer's disease? J Neurol Neurosurg Psychiatr 1986; 49: 216.
5. Jamieson GA, Maitland NJ, Wilcock GK, Craske J, Itzhaki RF. Latent herpes simplex virus type 1 in normal and Alzheimer's disease brains. J Med Virol 1991; 33: 224-27.
6. Jamieson GA, Maitland NJ, Wilcock GK, Craske J, Itzhaki RF. Herpes simplex virus type 1 DNA is present in specific reigons of brain from aged people with and without senile dementia of the Alzheimer type. J Pathol 1992; 167: 365-68.
7. Itzhaki RF, Maitland NJ, Wilcock GK, Yates CM, Jamieson GA. Detection by polymerase chain reaction of herpes simplex virus type 1 (HSV1) DNA in brain of aged normals and Alzheimer's disease patients. In: Corain B, Iqbal K, Nicolini M, Winblad B, Wisniewski H, Zatta P, eds. Alzheimer's disease: advances in clinical and basic research. New York: Wiley, 1993: 97-102.
8. Lin W-R, Shang D, Itzhaki RF. Neurotropic viruses and Alzheimer's disease: interaction of herpes simplex type 1 virus and apolipoprotein E in the aetiology of the disease. Molec Chem Neuropathol 1996; 28: 135-41.
9. Saldanha J, Sutton RNP, Gannicliffe A, Farragher B, Itzhaki RF. Detection of HSV1 DNA by in situ hybridisation in human brain after immunosuppression. J Neurol Neurosurg Psychiatr 1986; 49: 613-19.
10. Tanaka S, Minagawa H, Toh Y, Liu Y, More R. Analysis by RNA-PCR of latency and reactivation of herpes simplex virus in multiple neuronal tissues. J Gen Virol 1994; 75: 2691-98.
11. Tyler KL, Tedder DG, Yamamoto LJ, et al. Recurrent brain stem encephalitis associated with herpes simplex virus type 1 DNA in cerebrospinal fluid. Neurology 1995; 45: 2246-50.
12. Klapper PE, Cleator GM, Longson M. Mild forms of herpes encephalitis. J Neurol Neurosurg Psychiatr 1984; 47: 1247-50.
13. Saunders AM, Schmader K, Breitner JCS, et al. Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993; 43: 1467-72.
14. Lin W-R, Shang D, Itzhaki RF. Alzheimer's disease, herpes simplex virus type 1, cold sores and apolipoprotein E4. Biochem Soc Trans 1995; 23: 594S.
15. Wilcock GK, Hope RA, Brooks DN, et al. Recommended minimum data to be collected in research studies on Alzheimer's disease. J Neurol Neurosurg Psychiatr 1989; 52: 693-700.
16. Wenham PR, Price WH, Blundell G. Apolipoprotein E genotyping by one-stage PCR. Lancet 1991; 337: 1158-59.
17. Schachter F, Faure-Delanef L, Guenot F, et al. Genetic associations with human longevity at the APOE and ACE loci. Nat Genet 1994; 6: 29-32.
18. Cauley JA, Eichner JE, Kamboh MI, Ferrell RE, Kuller LH. ApoE allele frequencies in younger (age 42-50) vs older (age 65-90) women. Genet Epidemiol 1993; 10: 27-34.
19. Baringer JR, Pisani P. Herpes simplex virus genomes in human nervous system tissue analysed by polym erase chain reaction. Ann Neurol 1994; 36: 823-29.
20. Gordon L, McQuaid S, Cosby SL. Detection of herpes simplex virus (types 1 and 2) and human herpesvirus 6 DNA in human brain tissue by polymerase chain reaction. Clin Diag Virol 1996; 6: 33-40.
21. Breitner JCS, Gau BA, Welsh KA, et al. Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study. Neurology 1994; 44: 227-32.
22. Beyer CF, Tepper DJ, Hill JM. Cryogenic induced ocular HSV1 reactivation is enhanced by an inhibitor of the lipoxygenase pathway. Curr Eye Res 1989; 8: 1287-92.
23. Blyth WA, Hill TJ. Establishment, maintenance and control of herpes simplex virus (HSV) latency. In: Rouse BT, Lopez C, eds. The immunobiology of herpes simplex virus infection. Boca Raton: CRC Press, 1984: 10-32.
24. Herold BC, WuDunn D, Soltys N, Spear PG. Glycoprotein C of herpes simplex virus type 1 plays a principal role in the absorption of virus to cells and in infectivity. J Virol 1991; 65: 1090-98.
25. Ji ZS, Fazio S, Lee YL, Mahley RW. Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparin sulfate proteoglycans. J Biol Chem 1994; 269: 2764-72.
26. Nathan BP, Chang K-C, Bellosta S, et al. The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization. J Eiol Chem 1995; 270: 19791-99.