Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection

Journal of Lipid Research

Volumn 40, Issue 4, 1999, Pages 680-685

  De Bont, Natasja ^a   Netea, Mihai G ^a   Demacker, Pierre N M ^a   Verschueren, Ineke ^a   Kullberg, Bart Jan ^a   Van Dijk, Ko Willems ^b   Van Der Meer, Jos W M ^a   Stalenhoef, Anton F H ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apolipoprotein E; Hypercholesterolemia; Lipopolysaccharide; Neutralization; Tumor necrosis factor

Indexed keywords

APOLIPOPROTEIN E; BACTERIUM LIPOPOLYSACCHARIDE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; ENDOTOXEMIA; GRAM NEGATIVE INFECTION; HYPERCHOLESTEROLEMIA; INFLAMMATION; KLEBSIELLA PNEUMONIAE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APOLIPOPROTEINS E; CHOLESTEROL; CYTOKINES; DISEASE SUSCEPTIBILITY; ENDOTOXEMIA; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; LIPOPOLYSACCHARIDES; LIPOPROTEINS; LIPOPROTEINS, IDL; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; MICE; MICE, INBRED C57BL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032941090     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Lynn, W. A., and J. Gollen. 1995. Adjunctive therapy for septic shock: a review of experimental approaches. Clin. Infect. Dis. 20: 143-158.
2. Van Lenten, B. J., A. M. Fogelman, M. E. Haberland, and P. A. Edwards. 1986. The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide. Proc. Natl. Acad. Sci. USA. 83: 270-4-2708.
3. Harris, H. W., C. Grunfeld, K. R. Feingold, T. E. Read, J. P. Kane, A. I., Jones, E. B. Eichbaum, G. F. Bland, and J. H. Rapp. 1993. Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death. J. Clin. Invest. 91: 1028-1034.
4. Flegel, W. A., A. Wolpl, D. N. Mannel, and H. Northoff. 1989. Inhibition of endotoxin-induced activation of human monocytes by human lipoproteins. Infect. Immun. 57: 2237-2245.
5. Netea, M. G., N. de Bont, P. N. M. Demacker, B. J. Kullberg, L. E. H. Jacobs, T. J. G. Verver-Jansen, A. F. H. Stalenhoef, and J. W. M. van der Meer. 1998. Lipoprotein[a] inhibits the lipopolysaccharide-induced tumor necrosis factor-alpha production by human mononuclear cells. Infect. Immun. 66: 2365-2367.
6. Cavaillon, J. M., G. Fitting, N. Haeffner-Cavaillon, S. J. Kirsch, and H. S. Warren. 1990. Cytokine response by monocytes and macrophages to free and lipoprotein-bound lipopolysaccharide. Infect. Immun. 58: 2375-2382.
7. Weinstock, C., H. Ullrich, R. Hohe, A. Berg, M. W. Baumstark, I. Frey, H. Northoff, and W. A. Flegel. 1992. Low density lipoproteins inhibit endotoxin activation of monocytes. Arterioscler. Thromb. 12: 341-347.
8. Netea, M. G., P. N. Demacker, B. J. Kullberg, O. C. Boerman, I. Verschueren, A. F. Stalenhoef, and J. W. van der Meer. 1996. Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections. J. Clin. Invest. 97: 1366-1372.
9. Levine, D. M., T. S. Parker, T. M. Donnelly, A. Walsh, and A. L. Rubin. 1993. In vivo protection against endotoxin by plasma high density lipoprotein. Proc. Natl. Acad. Sci. USA. 90: 12040-12044.
10. Hubsch, A. P., F. S. Powell, P. G. Lerch, and J. E. Doran. 1993. A reconstituted, apolipoprotein A-I containing lipoprotein reduces tumor necrosis factor release and attenuates shock in endotoxemic rabbits. Circ. Shock. 40: 14-23.
11. Pajkrt, D., J. E. Doran, F. Koster, P. G. Lerch, B. Arnet, T. van der Poll, J. W. ten Cate, and S. J. H. van Deventer. 1996. Antiinflammatory effects of reconstituted high density lipoprotein during human endotoxemia. J. Exp. Med. 184: 1601-1608.
12. Harris, H. W., C. Grunfeld, K. R. Feingold, and J. H. Rapp. 1990. Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mice. J. Clin. Invest. 86: 696-702.
13. Read, T. E., C. Grunfeld, Z. L. Kumwenda, M. C. Calhoun, J. P. Kane, K. R. Feingold, and J. H. Rapp. 1995. Triglyceride-rich lipoproteins prevent septic death in rats. J. Exp. Med. 182: 267-272.
14. Rensen, P. C., M. Oosten, E. Bilt, M. Eck, J. Kuiper, and T. J. Berkel. 1997. Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats in vivo. J. Clin. Invest. 99: 2438-2445.
15. Flegel, W. A., M. W. Baumstark, C. Weinstock, A. Berg, and H. Northoff. 1993. Prevention of endotoxin-induced monokine release by human low and high density lipoproteins and by apolipoprotein A-I. Infect. Immun. 61: 5140-5146.
16. Emancipator, K., G. Csako, and R. J. Elin. 1992. In vitro inactivation of bacterial endotoxin by human lipoproteins and apolipoproteins. Infect. Immun. 60: 396-601.
17. Rensen, P. G. N., M. van Oosten, E. van de Bilt, M. van Eck, J. Kuiper, and T. J. C. van Berkel. 1997. Human apolipoprotein E protects against the deleterious effects of bacterial lipopolysaccharide in rats in vivo. Circulation. 379 (Abstract).
18. Parker, T. S., D. M. Levine, J. C. Chang, J. Laxer, C. C. Coffin, and A. L. Rubin. 1995. Reconstituted high-density lipoprotein neutralizes gram-negative bacterial lipopolysaccharides in human whole blood. Infect. Immun. 63: 253-258.
19. van Ree, J. H., W. J. van den Broek, V. E. Dahlmans, P. H. Groot, M. Vidgeon-Hart, R. R. Frants, B. Wieringa, L. M. Havekes, and M. H. Hofker. 1994. Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice. Atherosclerosis. 111: 25-37.
20. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
21. Vogels, M. T., F. J. Mensink, K. Ye, O. C. Boerman, C. M. Verschueren, C. A. Dinarello, and J. W. van der Meer. 1994. Differential gene expression for IL-1 receptor antagonist, IL-1, and TNF receptors and IL-1 and TNF synthesis may explain IL-1-induced resistance to infection. J. Immunol. 153: 5772-5780.
22. Roselaar, S. E., and A. Daugherty. 1998. Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo. J. Lipid. Res. 39: 1740-1743.
23. Ishibashi, S., M. S. Brown, J. L. Goldstein, R. D. Gerard, R. E. Hammer, and J. Herz. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments]. J. Clin. Invest. 92: 883-893.
24. van der Poll, T., G. C. Braxton, S. M. Coyle, M. A. Boermeester, J. C. Wang, P. M. Jansen, W. J. Montegut, S. E. Calvano, C. E. Hack, and S. F. Lowry. 1995. Effect of hypertriglyceridemia on endotoxin responsiveness in humans. Infect. Immun. 63: 3396-3400.
25. Praaning van Dalen, D. P., A. Brouwer, and D. L. Knook. 1981. Clearance capacity of rat liver Kupffer, endothelial, and parenchymal cells. Gastroenterology. 81: 1036-1044.
26. Munford, R. S., J. M. Andersen, and J. M. Dietschy. 1981. Sites of tissue binding and uptake in vivo of bacterial lipopolysaccharide-high density lipoprotein complexes: studies in the rat and squirrel monkey. J. Clin. Invest. 68: 1503-1513.
27. Zuckerman, S. H., and G. F. Evans. 1992. Endotoxin tolerance: in vivo regulation of tumor necrosis factor and interleukin-1 synthesis is at the transcriptional level. Cell. Immunol. 140: 513-519.
28. Netea, M. G., B. J. Kullberg, and J. W. M. van der Meer. 1998. Lipopolysaccharide-induced production of tumour necrosis factor and interleukin-1 is differtially regulated at the receptor level: the role of CD14-dependent and GD14-independent pathways. Immunology. 94: 340-344.