Neutralizing antibodies to IL-18 ameliorate experimental autoimmune neuritis by counter-regulation of autoreactive Th1 responses to peripheral myelin antigen

Journal of Neuropathology and Experimental Neurology

Volumn 61, Issue 7, 2002, Pages 614-622

  Yu, Shuo ^a   Chen, Zhiguo ^a   Mix, Eilhard ^a   Zhu, Shun Wei ^a   Winblad, Bengt ^a   Ljunggren, Hans Gustaf ^a   Zhu, Jie ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Experimental autoimmune neuritis; Guillain Barr syndrome; IL 18; Th1 Th2 cytokines; Therapy

Indexed keywords

ANTIBODY; INTERLEUKIN 18; INTERLEUKIN 18 ANTIBODY; MYELIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CELL INFILTRATION; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DEMYELINATING DISEASE; DRUG SCREENING; MONONUCLEAR CELL; MOUSE; NEURITIS; NONHUMAN; PRIORITY JOURNAL; TH1 CELL;

EID: 0036290511     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/61.7.614     Document Type: Article

References (47)

1. Induction of experimental allergic neuritis with synthetic peptides from myelin P2 protein
2. Nasal administration of recombinant rat IL-4 ameliorates ongoing experimental autoimmune neuritis and inhibits demyelination
3. A permanent rat T cell line that mediates experimental allergic neuritis in the Lewis rat in vivo
4. Cell adhesion molecules of the immunoglobulin supergene family as tissue-specific autoantigens: Induction of experimental allergic neuritis (EAN) by P0 protein-specific T cell lines
5. Experimental allergic neuritis (EAN) as a model for the immune-mediated demyelinating neuropathies
6. A novel costimmulatory factor for gamma interferon induction found in the livers of mice causes endotoxin shock
7. Cloning of a new cytokine that induces IFN-γ production by T cells
8. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but Th2 cells and exerts its effect independently of IL-12
9. + T cells but induces types I T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells
10. A newly defined interleukin-1?
11. IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor
12. Caspase-1 processes IFN- gamma-inducing factor and regulates LPS-induced IFN-gamma production
13. Interleukin-18
14. Interleukin 18: A pleiotropic participant in chronic inflammation
15. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFκB
16. Interleukin 18 together with Interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells
17. IL-12 up-regulates IL-18 receptor expression on T cell, Th1 cells, and B cells: Synergism with IL-18 for interferon-γ production
18. Interleukin-18 enhances lipopolysaccharide-induced interferon-gamma production in human whole blood cultures
19. IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses
20. Cytokine dichotomy in the peripheral nervous system influences the outcome of experimental allergic neuritis: Dynamics of mRNA expression for IL-1β, IL-6, IL-10, IL-12, TNF-α and TNF-β and cytolysin
21. Cytokine production and the pathogenesis of experimental autoimmune neuritis and Guilain-Barre syndrome
22. Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice
23. Neuroblastoma cells expressing mature IL-18, but not ProIL-18, induce a strong and immediate antitumor immune response
24. Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis
25. Casteels KIL-18 inhibits diabetes development in nonobese diabetic mice by counterregulation of Th1-dependent destructive insulitis
26. Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18
27. Interleukin-18 is induced in acute inflammatory demyelinating polyneuropathy
28. Prevention of experimental autoimmune neuritis by nasal administration of P2 protein peptides 57-81
29. Defective NK cell activity and Th1 response in IL-18-deficient mice
30. IFN-γ-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma
31. Astrocytes and microglia produce IL-12 p40
32. + T cells: Evidence for two distinct pathways for promoter activation
33. Interleukin-18: Biological properties and clinical implications
34. IL-18 directs autoreactive T cell and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells
35. Th1/Th2 paradigm
36. Pathogenesis of inflammatory demyelination: Implications for therapy
37. Activated T cells of nonneural specificity open the blood-nerve barrier to circulating antibody
38. Enhancement of acute phase and inhibition of chronic phase of experimental autoimmune neuritis in Lewis rats by intranasal administration of recombinant mouse interleukin 17: Potential immunoregulatory role
39. The expression of cytokine mRNA in the cauda equina of Lewis rats with experimental allergic neuritis
40. IL-10 suppresses experimental autoimmune neuritis and down-regulates Th1-type immune responses
41. The presence of interleukin-4 during in vitro priming determine the cytokine-producing potential of CD4+ T cells from T cell receptor transgenic mice
42. Cognate interactions between helper T cells and B cells
43. Antiserum-mediated demyelination: Relationship between remyelination and functional recovery
44. Antigalactocerebroside antibody increases demyelination in adoptive transfer experimental allergic neuritis
45. Cellular mRNA expression of interferon-γ, interleukin 4 and tranforming growth factor β by rat mononuclear cells stimulated with peripheral nerve myelin antigens in experimental allergic neuritis
46. Intraneural activated T cells cause focal breakdown of the blood-nerve barrier
47. Interleukin-12 induced interferonγ-dependent switching of IgG alloantibody subclass