메뉴 건너뛰기




Volumn 2010, Issue , 2010, Pages

The immune-modulatory role of apolipoprotein e with emphasis on multiple sclerosis and experimental autoimmune encephalomyelitis

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; BIOLOGICAL MARKER;

EID: 77953518270     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2010/186813     Document Type: Review
Times cited : (80)

References (134)
  • 1
    • 0028303072 scopus 로고
    • Apolipoprotein E: Structure-function relationships
    • Weisgraber K. H., Apolipoprotein E: structure-function relationships Advances in Protein Chemistry 1994 45 249 302
    • (1994) Advances in Protein Chemistry , vol.45 , pp. 249-302
    • Weisgraber, K.H.1
  • 3
    • 48349148598 scopus 로고    scopus 로고
    • Infection induces a positive acute phase apolipoprotein e response from a negative acute phase gene: Role of hepatic LDL receptors
    • Li L., Thompson P. A., Kitchens R. L., Infection induces a positive acute phase apolipoprotein E response from a negative acute phase gene: role of hepatic LDL receptors Journal of Lipid Research 2008 49 8 1782 1793
    • (2008) Journal of Lipid Research , vol.49 , Issue.8 , pp. 1782-1793
    • Li, L.1    Thompson, P.A.2    Kitchens, R.L.3
  • 4
    • 0024299370 scopus 로고
    • Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
    • Mahley R. W., Apolipoprotein E: cholesterol transport protein with expanding role in cell biology Science 1988 240 4852 622 630
    • (1988) Science , vol.240 , Issue.4852 , pp. 622-630
    • Mahley, R.W.1
  • 5
    • 0022350033 scopus 로고
    • Apolipoprotein e associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system
    • Boyles J. K., Pitas R. E., Wilson E., Mahley R. W., Taylor J. M., Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system The Journal of Clinical Investigation 1985 76 4 1501 1513
    • (1985) The Journal of Clinical Investigation , vol.76 , Issue.4 , pp. 1501-1513
    • Boyles, J.K.1    Pitas, R.E.2    Wilson, E.3    Mahley, R.W.4    Taylor, J.M.5
  • 6
    • 4143055668 scopus 로고    scopus 로고
    • Apolipoprotein E4 as a target for developing new therapeutics for Alzheimer's disease
    • Refolo L. M., Fillit H. M., Apolipoprotein E4 as a target for developing new therapeutics for Alzheimer's disease Journal of Molecular Neuroscience 2004 23 3 151 155
    • (2004) Journal of Molecular Neuroscience , vol.23 , Issue.3 , pp. 151-155
    • Refolo, L.M.1    Fillit, H.M.2
  • 7
    • 34247391459 scopus 로고    scopus 로고
    • A pathway-dependent on ApoE, ApoAI, and ABCA1 determines formation of buoyant high-density lipoprotein by macrophage foam cells
    • Yancey P. G., Yu H., Linton M. F., Fazio S., A pathway-dependent on ApoE, ApoAI, and ABCA1 determines formation of buoyant high-density lipoprotein by macrophage foam cells Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 5 1123 1131
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , Issue.5 , pp. 1123-1131
    • Yancey, P.G.1    Yu, H.2    Linton, M.F.3    Fazio, S.4
  • 8
    • 66249139187 scopus 로고    scopus 로고
    • Association of prior stroke with cognitive function and cognitive impairment: A population-based study
    • Knopman D. S., Roberts R. O., Geda Y. E., Association of prior stroke with cognitive function and cognitive impairment: a population-based study Archives of Neurology 2009 66 5 614 619
    • (2009) Archives of Neurology , vol.66 , Issue.5 , pp. 614-619
    • Knopman, D.S.1    Roberts, R.O.2    Geda, Y.E.3
  • 9
    • 68249134074 scopus 로고    scopus 로고
    • The role of apolipoprotein e in Alzheimer's disease
    • Kim J., Basak J. M., Holtzman D. M., The role of apolipoprotein E in Alzheimer's disease Neuron 2009 63 3 287 303
    • (2009) Neuron , vol.63 , Issue.3 , pp. 287-303
    • Kim, J.1    Basak, J.M.2    Holtzman, D.M.3
  • 10
    • 0035242698 scopus 로고    scopus 로고
    • Apolipoprotein e genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: Variation by use of antihypertensive medication?
    • Guo Z., Fratiglioni L., Viitanen M., Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication? American Journal of Epidemiology 2001 153 3 225 231
    • (2001) American Journal of Epidemiology , vol.153 , Issue.3 , pp. 225-231
    • Guo, Z.1    Fratiglioni, L.2    Viitanen, M.3
  • 11
    • 44949221768 scopus 로고    scopus 로고
    • Increased CSF-BACE 1 activity is associated with ApoE- 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease
    • Ewers M., Zhong Z., Brger K., Increased CSF-BACE 1 activity is associated with ApoE- 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease Brain 2008 131 5 1252 1258
    • (2008) Brain , vol.131 , Issue.5 , pp. 1252-1258
    • Ewers, M.1    Zhong, Z.2    Brger, K.3
  • 12
    • 73649133620 scopus 로고    scopus 로고
    • Apolipoprotein e allele 4 is not a sufficient or a necessary predictor of the development of Mild Cognitive Impairment
    • Heun R., Ghne U., Luck T., Apolipoprotein E allele 4 is not a sufficient or a necessary predictor of the development of Mild Cognitive Impairment European Psychiatry 2010 25 1 15 18
    • (2010) European Psychiatry , vol.25 , Issue.1 , pp. 15-18
    • Heun, R.1    Ghne, U.2    Luck, T.3
  • 13
    • 0020313079 scopus 로고
    • Apoprotein e suppresses phytohemagglutinin-activated phospholipid turnover in peripheral blood mononuclear cells
    • Avila E. M., Holdsworth G., Sasaki N., Jackson R. L., Harmony J. A., Apoprotein E suppresses phytohemagglutinin-activated phospholipid turnover in peripheral blood mononuclear cells The Journal of Biological Chemistry 1982 257 10 5900 5909
    • (1982) The Journal of Biological Chemistry , vol.257 , Issue.10 , pp. 5900-5909
    • Avila, E.M.1    Holdsworth, G.2    Sasaki, N.3    Jackson, R.L.4    Harmony, J.A.5
  • 14
    • 0026033247 scopus 로고
    • Apolipoprotein (Apo) e inhibits the capacity of monosodium urate crystals to stimulate neutrophils. Characterization of intraarticular Apo e and demonstration of Apo e binding to urate crystals in vivo
    • Terkeltaub R. A., Dyer C. A., Martin J., Curtiss L. K., Apolipoprotein (Apo) E inhibits the capacity of monosodium urate crystals to stimulate neutrophils. Characterization of intraarticular Apo E and demonstration of Apo E binding to urate crystals in vivo The Journal of Clinical Investigation 1991 87 1 20 26
    • (1991) The Journal of Clinical Investigation , vol.87 , Issue.1 , pp. 20-26
    • Terkeltaub, R.A.1    Dyer, C.A.2    Martin, J.3    Curtiss, L.K.4
  • 15
    • 67649104088 scopus 로고    scopus 로고
    • APOE genotype-specific differences in the innate immune response
    • Vitek M. P., Brown C. M., Colton C. A., APOE genotype-specific differences in the innate immune response Neurobiology of Aging 2009 30 9 1350 1360
    • (2009) Neurobiology of Aging , vol.30 , Issue.9 , pp. 1350-1360
    • Vitek, M.P.1    Brown, C.M.2    Colton, C.A.3
  • 16
    • 0030610645 scopus 로고    scopus 로고
    • Microglial activation by alzhelmer amyloid precursor protein and modulation by apolipoprotein e
    • Barger S. W., Harmon A. D., Microglial activation by alzhelmer amyloid precursor protein and modulation by apolipoprotein E Nature 1997 388 6645 878 881
    • (1997) Nature , vol.388 , Issue.6645 , pp. 878-881
    • Barger, S.W.1    Harmon, A.D.2
  • 18
    • 0036752024 scopus 로고    scopus 로고
    • APOE and the regulation of microglial nitric oxide production: A link between genetic risk and oxidative stress
    • Colton C. A., Brown C. M., Cook D., APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress Neurobiology of Aging 2002 23 5 777 785
    • (2002) Neurobiology of Aging , vol.23 , Issue.5 , pp. 777-785
    • Colton, C.A.1    Brown, C.M.2    Cook, D.3
  • 19
    • 27144481169 scopus 로고    scopus 로고
    • Apolipoprotein-mediated pathways of lipid antigen presentation
    • van den Elzen P., Garg S., Len L., Apolipoprotein-mediated pathways of lipid antigen presentation Nature 2005 437 7060 906 910
    • (2005) Nature , vol.437 , Issue.7060 , pp. 906-910
    • Van Den Elzen, P.1    Garg, S.2    Len, L.3
  • 20
    • 34447131000 scopus 로고    scopus 로고
    • CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor
    • Borg N. A., Wun K. S., Kjer-Nielsen L., CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor Nature 2007 448 7149 44 49
    • (2007) Nature , vol.448 , Issue.7149 , pp. 44-49
    • Borg, N.A.1    Wun, K.S.2    Kjer-Nielsen, L.3
  • 22
    • 0016314761 scopus 로고
    • A lymphocyte inhibiting factor isolated from normal human liver
    • Schumacher K., Maerker-Alzer G., Wehmer U., A lymphocyte inhibiting factor isolated from normal human liver Nature 1974 251 5476 655 656
    • (1974) Nature , vol.251 , Issue.5476 , pp. 655-656
    • Schumacher, K.1    Maerker-Alzer, G.2    Wehmer, U.3
  • 23
    • 0018864316 scopus 로고
    • Direct suppression of lymphocyte induction by the immunoregulatory human serum low density lipoprotein, LDL-In
    • Fujii D. K., Edgington T. S., Direct suppression of lymphocyte induction by the immunoregulatory human serum low density lipoprotein, LDL-In The Journal of Immunology 1980 124 1 156 160
    • (1980) The Journal of Immunology , vol.124 , Issue.1 , pp. 156-160
    • Fujii, D.K.1    Edgington, T.S.2
  • 24
    • 0019214788 scopus 로고
    • Phosphatidylinositol turnover in mitogen-activated lymphocytes. Suppression by low-density lipoproteins
    • Hui D. Y., Harmony J. A. K., Phosphatidylinositol turnover in mitogen-activated lymphocytes. Suppression by low-density lipoproteins Biochemical Journal 1980 192 1 91 98
    • (1980) Biochemical Journal , vol.192 , Issue.1 , pp. 91-98
    • Hui, D.Y.1    Harmony, J.A.K.2
  • 26
    • 0022608931 scopus 로고
    • Apolipoprotein e is a biologically active constituent of the normal immunoregulatory lipoprotein, LDL-In
    • Pepe M. G., Curtiss L. K., Apolipoprotein E is a biologically active constituent of the normal immunoregulatory lipoprotein, LDL-In The Journal of Immunology 1986 136 10 3716 3723
    • (1986) The Journal of Immunology , vol.136 , Issue.10 , pp. 3716-3723
    • Pepe, M.G.1    Curtiss, L.K.2
  • 27
    • 0028939267 scopus 로고
    • Apolipoprotein e restricts interleukin-dependent T lymphocyte proliferation at the G1A / G1B boundary
    • Mistry M. J., Clay M. A., Kelly M. E., Steiner M. A., Harmony J. A. K., Apolipoprotein E restricts interleukin-dependent T lymphocyte proliferation at the G1A / G1B boundary Cellular Immunology 1995 160 1 14 23
    • (1995) Cellular Immunology , vol.160 , Issue.1 , pp. 14-23
    • Mistry, M.J.1    Clay, M.A.2    Kelly, M.E.3    Steiner, M.A.4    Harmony, J.A.K.5
  • 29
    • 66349101348 scopus 로고    scopus 로고
    • Apoprotein e as a lipid transport and signaling protein in the blood, liver, and artery wall
    • supplement
    • Getz G. S., Reardon C. A., Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall Journal of lipid research 2009 50 supplement S156 S161
    • (2009) Journal of Lipid Research , vol.50
    • Getz, G.S.1    Reardon, C.A.2
  • 30
    • 0035838424 scopus 로고    scopus 로고
    • In vivo downregulation of T helper cell 1 immune responses reduces atherogenesis in apolipoprotein E-knockout mice
    • Laurat E., Poirier B., Tupin E., In vivo downregulation of T helper cell 1 immune responses reduces atherogenesis in apolipoprotein E-knockout mice Circulation 2001 104 2 197 202
    • (2001) Circulation , vol.104 , Issue.2 , pp. 197-202
    • Laurat, E.1    Poirier, B.2    Tupin, E.3
  • 31
    • 27644482670 scopus 로고    scopus 로고
    • Apolipoprotein e suppresses the type i inflammatory response in vivo
    • Ali K., Middleton M., Pur E., Rader D. J., Apolipoprotein E suppresses the type I inflammatory response in vivo Circulation Research 2005 97 9 922 927
    • (2005) Circulation Research , vol.97 , Issue.9 , pp. 922-927
    • Ali, K.1    Middleton, M.2    Pur, E.3    Rader, D.J.4
  • 32
    • 1542467336 scopus 로고    scopus 로고
    • APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response
    • Lynch J. R., Tang W., Wang H., APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response The Journal of Biological Chemistry 2003 278 49 48529 48533
    • (2003) The Journal of Biological Chemistry , vol.278 , Issue.49 , pp. 48529-48533
    • Lynch, J.R.1    Tang, W.2    Wang, H.3
  • 33
    • 0035937812 scopus 로고    scopus 로고
    • Apolipoprotein e protects against bacterial lipopolysaccharide-induced lethality: A new therapeutic approach to treat gram-negative sepsis
    • Van Oosten M., Rensen P. C. N., Van Amersfoort E. S., Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality: a new therapeutic approach to treat gram-negative sepsis The Journal of Biological Chemistry 2001 276 12 8820 8824
    • (2001) The Journal of Biological Chemistry , vol.276 , Issue.12 , pp. 8820-8824
    • Van Oosten, M.1    Rensen, P.C.N.2    Van Amersfoort, E.S.3
  • 34
    • 0032941090 scopus 로고    scopus 로고
    • Apolipoprotein e knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection
    • de Bont N., Netea M. G., Demacker P. N. M., Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection Journal of Lipid Research 1999 40 4 680 685
    • (1999) Journal of Lipid Research , vol.40 , Issue.4 , pp. 680-685
    • De Bont, N.1    Netea, M.G.2    Demacker, P.N.M.3
  • 35
    • 0031687891 scopus 로고    scopus 로고
    • Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo
    • Roselaar S. E., Daugherty A., Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo Journal of Lipid Research 1998 39 9 1740 1743
    • (1998) Journal of Lipid Research , vol.39 , Issue.9 , pp. 1740-1743
    • Roselaar, S.E.1    Daugherty, A.2
  • 37
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S., Alternative activation of macrophages Nature Reviews Immunology 2003 3 1 23 35
    • (2003) Nature Reviews Immunology , vol.3 , Issue.1 , pp. 23-35
    • Gordon, S.1
  • 39
    • 0038803973 scopus 로고    scopus 로고
    • Apolipoprotein e modulates immune activation by acting on the antigen-presenting cell
    • Tenger C., Zhou X., Apolipoprotein E modulates immune activation by acting on the antigen-presenting cell Immunology 2003 109 3 392 397
    • (2003) Immunology , vol.109 , Issue.3 , pp. 392-397
    • Tenger, C.1    Zhou, X.2
  • 40
    • 33646242262 scopus 로고    scopus 로고
    • Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein e gene and is mediated by microglial p38MAPK
    • Maezawa I., Nivison M., Montine K. S., Maeda N., Montine T. J., Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK The FASEB Journal 2006 20 6 797 799
    • (2006) The FASEB Journal , vol.20 , Issue.6 , pp. 797-799
    • Maezawa, I.1    Nivison, M.2    Montine, K.S.3    Maeda, N.4    Montine, T.J.5
  • 41
    • 0038810288 scopus 로고    scopus 로고
    • Microglial apolipoprotein e and astroglial apolipoprotein J expression in vitro: Opposite effects of lipopolysaccharide
    • Saura J., Petegnief V., Wu X., Liang Y., Paul S. M., Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide Journal of Neurochemistry 2003 85 6 1455 1467
    • (2003) Journal of Neurochemistry , vol.85 , Issue.6 , pp. 1455-1467
    • Saura, J.1    Petegnief, V.2    Wu, X.3    Liang, Y.4    Paul, S.M.5
  • 42
    • 0020629312 scopus 로고
    • Apoprotein e is synthesized and secreted by resident and thioglycollate-elicited macrophages but not by pyran copolymer- or bacillus Calmette-Guerin-activated macrophages
    • Werb Z., Chin J. R., Apoprotein E is synthesized and secreted by resident and thioglycollate-elicited macrophages but not by pyran copolymer- or bacillus Calmette-Guerin-activated macrophages The Journal of Experimental Medicine 1983 158 4 1272 1293
    • (1983) The Journal of Experimental Medicine , vol.158 , Issue.4 , pp. 1272-1293
    • Werb, Z.1    Chin, J.R.2
  • 43
    • 0031576547 scopus 로고    scopus 로고
    • Modulation of nitric oxide production in human macrophages by apolipoprotein-E and amyloid-beta peptide
    • DOI 10.1006/bbrc.1997.7408
    • Vitek M. P., Snell J., Dawson H., Colton C. A., Modulation of nitric oxide production in human macrophages by apolipoprotein-E and amyloid-beta peptide Biochemical and Biophysical Research Communications 1997 240 2 391 394 (Pubitemid 27523670)
    • (1997) Biochemical and Biophysical Research Communications , vol.240 , Issue.2 , pp. 391-394
    • Vitek, M.P.1    Snell, J.2    Dawson, H.3    Colton, C.A.4
  • 44
    • 0037219011 scopus 로고    scopus 로고
    • Microglial function in human APOE3 and APOE4 transgenic mice: Altered arginine transport
    • Czapiga M., Colton C. A., Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport Journal of Neuroimmunology 2003 134 1-2 44 51
    • (2003) Journal of Neuroimmunology , vol.134 , Issue.12 , pp. 44-51
    • Czapiga, M.1    Colton, C.A.2
  • 46
    • 0038342438 scopus 로고    scopus 로고
    • Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites
    • Chaussabel D., Semnani R. T., McDowell M. A., Sacks D., Sher A., Nutman T. B., Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites Blood 2003 102 2 672 681
    • (2003) Blood , vol.102 , Issue.2 , pp. 672-681
    • Chaussabel, D.1    Semnani, R.T.2    McDowell, M.A.3    Sacks, D.4    Sher, A.5    Nutman, T.B.6
  • 47
    • 0035947669 scopus 로고    scopus 로고
    • Profiling changes in gene expression during differentiation and maturation of monocyte-derived dendritic cells using both oligonucleotide microarrays and proteomics
    • Le Naour F., Hohenkirk L., Grolleau A., Profiling changes in gene expression during differentiation and maturation of monocyte-derived dendritic cells using both oligonucleotide microarrays and proteomics The Journal of Biological Chemistry 2001 276 21 17920 17931
    • (2001) The Journal of Biological Chemistry , vol.276 , Issue.21 , pp. 17920-17931
    • Le Naour, F.1    Hohenkirk, L.2    Grolleau, A.3
  • 48
    • 0029562066 scopus 로고
    • Role of NK1.1+ T cells in a TH2 response and in immunoglobulin e production
    • Yoshimoto T., Bendelac A., Watson C., Hu-Li J., Paul W. E., Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production Science 1995 270 5243 1845 1847
    • (1995) Science , vol.270 , Issue.5243 , pp. 1845-1847
    • Yoshimoto, T.1    Bendelac, A.2    Watson, C.3    Hu-Li, J.4    Paul, W.E.5
  • 49
    • 0035905471 scopus 로고    scopus 로고
    • Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis
    • Singh A. K., Wilson M. T., Hong S., Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis The Journal of Experimental Medicine 2001 194 12 1801 1811
    • (2001) The Journal of Experimental Medicine , vol.194 , Issue.12 , pp. 1801-1811
    • Singh, A.K.1    Wilson, M.T.2    Hong, S.3
  • 50
    • 70350494273 scopus 로고    scopus 로고
    • Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells
    • Allan L. L., Hoefl K., Zheng D.-J., Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells Blood 2009 114 12 2411 2416
    • (2009) Blood , vol.114 , Issue.12 , pp. 2411-2416
    • Allan, L.L.1    Hoefl, K.2    Zheng, D.-J.3
  • 51
    • 1342321659 scopus 로고    scopus 로고
    • CD1d-dependent activation of NKT cells aggravates atherosclerosis
    • Tupin E., Nicoletti A., Elhage R., CD1d-dependent activation of NKT cells aggravates atherosclerosis The Journal of Experimental Medicine 2004 199 3 417 422
    • (2004) The Journal of Experimental Medicine , vol.199 , Issue.3 , pp. 417-422
    • Tupin, E.1    Nicoletti, A.2    Elhage, R.3
  • 53
    • 0035845431 scopus 로고    scopus 로고
    • Apolipoprotein e 4 is associated with rapid progression of multiple sclerosis
    • Fazekas F., Strasser-Fuchs S., Kollegger H., Apolipoprotein E 4 is associated with rapid progression of multiple sclerosis Neurology 2001 57 5 853 857
    • (2001) Neurology , vol.57 , Issue.5 , pp. 853-857
    • Fazekas, F.1    Strasser-Fuchs, S.2    Kollegger, H.3
  • 54
    • 53649097589 scopus 로고    scopus 로고
    • The APOE4 genotype alters the response of microglia and macrophages to 17 -estradiol
    • Brown C. M., Choi E., Xu Q., Vitek M. P., Colton C. A., The APOE4 genotype alters the response of microglia and macrophages to 17 -estradiol Neurobiology of Aging 2008 29 12 1783 1794
    • (2008) Neurobiology of Aging , vol.29 , Issue.12 , pp. 1783-1794
    • Brown, C.M.1    Choi, E.2    Xu, Q.3    Vitek, M.P.4    Colton, C.A.5
  • 55
    • 33746053293 scopus 로고    scopus 로고
    • Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice
    • Maezawa I., Maeda N., Montine T. J., Montine K. S., Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice Journal of Neuroinflammation 2006 3 1 10
    • (2006) Journal of Neuroinflammation , vol.3 , Issue.1 , pp. 10
    • Maezawa, I.1    Maeda, N.2    Montine, T.J.3    Montine, K.S.4
  • 56
    • 38949163967 scopus 로고    scopus 로고
    • Impact of apoE genotype on oxidative stress, inflammation and disease risk
    • DOI 10.1002/mnfr.200700322
    • Jofre-Monseny L., Minihane A.-M., Rimbach G., Impact of apoE genotype on oxidative stress, inflammation and disease risk Molecular Nutrition Food Research 2008 52 1 131 145 (Pubitemid 351211806)
    • (2008) Molecular Nutrition and Food Research , vol.52 , Issue.1 , pp. 131-145
    • Jofre-Monseny, L.1    Minihane, A.-M.2    Rimbach, G.3
  • 58
    • 23244454385 scopus 로고    scopus 로고
    • The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor
    • Ruiz J., Kouiavskaia D., Migliorini M., The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor Journal of Lipid Research 2005 46 8 1721 1731
    • (2005) Journal of Lipid Research , vol.46 , Issue.8 , pp. 1721-1731
    • Ruiz, J.1    Kouiavskaia, D.2    Migliorini, M.3
  • 59
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A., Coles A., Multiple sclerosis The Lancet 2008 372 9648 1502 1517
    • (2008) The Lancet , vol.372 , Issue.9648 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 61
    • 2342527831 scopus 로고    scopus 로고
    • Influence of apolipoprotein e 4 genotype on brain tissue integrity in relapsing-remitting multiple sclerosis
    • De Stefano N., Bartolozzi M. L., Nacmias B., Influence of apolipoprotein E 4 genotype on brain tissue integrity in relapsing-remitting multiple sclerosis Archives of Neurology 2004 61 4 536 540
    • (2004) Archives of Neurology , vol.61 , Issue.4 , pp. 536-540
    • De Stefano, N.1    Bartolozzi, M.L.2    Nacmias, B.3
  • 62
    • 0019979691 scopus 로고
    • Genetic control of human apolipoprotein e polymorphismml: Comparison of one- and two-dimensional techniques of isoprotein analysis
    • Utermann G., Steinmetz A., Weber W., Genetic control of human apolipoprotein E polymorphismml: comparison of one- and two-dimensional techniques of isoprotein analysis Human Genetics 1982 60 4 344 351
    • (1982) Human Genetics , vol.60 , Issue.4 , pp. 344-351
    • Utermann, G.1    Steinmetz, A.2    Weber, W.3
  • 63
    • 0020618569 scopus 로고
    • Apolipoprotein e polymorphism and coronary artery disease
    • Menzel H. J., Kladetzky R. G., Assmann G., Apolipoprotein E polymorphism and coronary artery disease Arteriosclerosis 1983 3 4 310 315
    • (1983) Arteriosclerosis , vol.3 , Issue.4 , pp. 310-315
    • Menzel, H.J.1    Kladetzky, R.G.2    Assmann, G.3
  • 64
    • 3142556134 scopus 로고    scopus 로고
    • Development of biomarkers in multiple sclerosis
    • Bielekova B., Martin R., Development of biomarkers in multiple sclerosis Brain 2004 127 7 1463 1478
    • (2004) Brain , vol.127 , Issue.7 , pp. 1463-1478
    • Bielekova, B.1    Martin, R.2
  • 65
    • 34247139196 scopus 로고    scopus 로고
    • Proteomic identification of potential protein markers in cerebrospinal fluid of GBS patients
    • Jin T., Hu L.-S., Chang M., Wu J., Winblad B., Zhu J., Proteomic identification of potential protein markers in cerebrospinal fluid of GBS patients European Journal of Neurology 2007 14 5 563 568
    • (2007) European Journal of Neurology , vol.14 , Issue.5 , pp. 563-568
    • Jin, T.1    Hu, L.-S.2    Chang, M.3    Wu, J.4    Winblad, B.5    Zhu, J.6
  • 66
    • 46149089887 scopus 로고    scopus 로고
    • Comparative proteomics analysis of cerebrospinal fluid of patients with Guillain-Barr syndrome
    • Yang Y.-R., Liu S.-L., Qin Z.-Y., Comparative proteomics analysis of cerebrospinal fluid of patients with Guillain-Barr syndrome Cellular and Molecular Neurobiology 2008 28 5 737 744
    • (2008) Cellular and Molecular Neurobiology , vol.28 , Issue.5 , pp. 737-744
    • Yang, Y.-R.1    Liu, S.-L.2    Qin, Z.-Y.3
  • 68
    • 0032581174 scopus 로고    scopus 로고
    • Apolipoprotein e and multiple sclerosis: A biochemical and genetic investigation
    • Gaillard O., Gervais A., Meillet D., Apolipoprotein E and multiple sclerosis: a biochemical and genetic investigation Journal of the Neurological Sciences 1998 158 2 180 186
    • (1998) Journal of the Neurological Sciences , vol.158 , Issue.2 , pp. 180-186
    • Gaillard, O.1    Gervais, A.2    Meillet, D.3
  • 70
    • 0025878638 scopus 로고
    • Phenotypes of apolipoprotein B and apolipoprotein e after liver transplantation
    • Linton M. F., Gish R., Hubl S. T., Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation The Journal of Clinical Investigation 1991 88 1 270 281
    • (1991) The Journal of Clinical Investigation , vol.88 , Issue.1 , pp. 270-281
    • Linton, M.F.1    Gish, R.2    Hubl, S.T.3
  • 71
    • 66349085616 scopus 로고    scopus 로고
    • Apolipoprotein E: Structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
    • supplement
    • Mahley R. W., Weisgraber K. H., Huang Y., Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS Journal of Lipid Research 2009 50 supplement S183 S188
    • (2009) Journal of Lipid Research , vol.50
    • Mahley, R.W.1    Weisgraber, K.H.2    Huang, Y.3
  • 72
    • 11144297111 scopus 로고    scopus 로고
    • Biological markers in CSF and blood for axonal degeneration in multiple sclerosis
    • Teunissen C. E., Dijkstra P. C., Polman C., Biological markers in CSF and blood for axonal degeneration in multiple sclerosis Lancet Neurology 2005 4 1 32 41
    • (2005) Lancet Neurology , vol.4 , Issue.1 , pp. 32-41
    • Teunissen, C.E.1    Dijkstra, P.C.2    Polman, C.3
  • 73
    • 49549111384 scopus 로고    scopus 로고
    • CSF proteome analysis in multiple sclerosis patients by two-dimensional electrophoresis
    • Chiasserini D., Di Filippo M., Candeliere A., CSF proteome analysis in multiple sclerosis patients by two-dimensional electrophoresis European Journal of Neurology 2008 15 9 998 1001
    • (2008) European Journal of Neurology , vol.15 , Issue.9 , pp. 998-1001
    • Chiasserini, D.1    Di Filippo, M.2    Candeliere, A.3
  • 74
    • 0009573338 scopus 로고    scopus 로고
    • A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex
    • Haines J. L., Ter-Minassian M., Bazyk A., A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex Nature Genetics 1996 13 4 469 471
    • (1996) Nature Genetics , vol.13 , Issue.4 , pp. 469-471
    • Haines, J.L.1    Ter-Minassian, M.2    Bazyk, A.3
  • 76
    • 33845623832 scopus 로고    scopus 로고
    • Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: Interaction with 2p11, 12q24 and 19q13 in European Americans
    • Xing C., Sestak A. L., Kelly J. A., Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans Human Genetics 2007 120 5 623 631
    • (2007) Human Genetics , vol.120 , Issue.5 , pp. 623-631
    • Xing, C.1    Sestak, A.L.2    Kelly, J.A.3
  • 77
    • 0038341659 scopus 로고    scopus 로고
    • The common polymorphism of apolipoprotein E: Geographical aspects and new pathophysiological relations
    • Gerdes L. U., The common polymorphism of apolipoprotein E: geographical aspects and new pathophysiological relations Clinical Chemistry and Laboratory Medicine 2003 41 5 628 631
    • (2003) Clinical Chemistry and Laboratory Medicine , vol.41 , Issue.5 , pp. 628-631
    • Gerdes, L.U.1
  • 79
    • 0033546758 scopus 로고    scopus 로고
    • APOE 24 and -491 polymorphisms are not associated with MS
    • Ferri C., Sciacca F. L., Veglia F., APOE 24 and -491 polymorphisms are not associated with MS Neurology 1999 53 4 888 889
    • (1999) Neurology , vol.53 , Issue.4 , pp. 888-889
    • Ferri, C.1    Sciacca, F.L.2    Veglia, F.3
  • 80
    • 0036198744 scopus 로고    scopus 로고
    • APOE genotypes and disease severity in multiple sclerosis
    • Masterman T., Zhang Z., Hellgren D., APOE genotypes and disease severity in multiple sclerosis Multiple Sclerosis 2002 8 2 98 103
    • (2002) Multiple Sclerosis , vol.8 , Issue.2 , pp. 98-103
    • Masterman, T.1    Zhang, Z.2    Hellgren, D.3
  • 81
    • 0026698267 scopus 로고
    • Apolipoprotein e polymorphism in a Danish population compared to findings in 45 other study populations around the world
    • Gerdes L. U., Klausen I. C., Sihm I., Frgeman O., Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world Genetic Epidemiology 1992 9 3 155 167
    • (1992) Genetic Epidemiology , vol.9 , Issue.3 , pp. 155-167
    • Gerdes, L.U.1    Klausen, I.C.2    Sihm, I.3    Frgeman, O.4
  • 82
    • 9444220197 scopus 로고    scopus 로고
    • The relationship of APOE genetic polymorphism with susceptibility to multiple sclerosis and its clinical phenotypes in Kuwaiti Arab subjects
    • Al-Shammri S., Fatania H., Al-Radwan R., Akanji A. O., The relationship of APOE genetic polymorphism with susceptibility to multiple sclerosis and its clinical phenotypes in Kuwaiti Arab subjects Clinica Chimica Acta 2005 351 1-2 203 207
    • (2005) Clinica Chimica Acta , vol.351 , Issue.12 , pp. 203-207
    • Al-Shammri, S.1    Fatania, H.2    Al-Radwan, R.3    Akanji, A.O.4
  • 83
    • 25844450924 scopus 로고    scopus 로고
    • Apo e in multiple sclerosis and optic neuritis: The Apo E- 4 allele is associated with progression of multiple sclerosis
    • Pinholt M., Frederiksen J. L., Andersen P. S., Christiansen M., Apo E in multiple sclerosis and optic neuritis: the Apo E- 4 allele is associated with progression of multiple sclerosis Multiple Sclerosis 2005 11 5 511 515
    • (2005) Multiple Sclerosis , vol.11 , Issue.5 , pp. 511-515
    • Pinholt, M.1    Frederiksen, J.L.2    Andersen, P.S.3    Christiansen, M.4
  • 84
    • 0033842879 scopus 로고    scopus 로고
    • Apoliprotein e and multiple sclerosis: Impact of the epsilon-4 allele on susceptibility, clinical type and progression rate
    • Hgh P., Oturai A., Schreiber K., Apoliprotein E and multiple sclerosis: impact of the epsilon-4 allele on susceptibility, clinical type and progression rate Multiple Sclerosis 2000 6 4 226 230
    • (2000) Multiple Sclerosis , vol.6 , Issue.4 , pp. 226-230
    • Hgh, P.1    Oturai, A.2    Schreiber, K.3
  • 85
    • 34548299105 scopus 로고    scopus 로고
    • Risk alleles for multiple sclerosis identified by a genomewide study
    • Hafler D. A., Compston A., Sawcer S., Risk alleles for multiple sclerosis identified by a genomewide study The New England Journal of Medicine 2007 357 9 851 862
    • (2007) The New England Journal of Medicine , vol.357 , Issue.9 , pp. 851-862
    • Hafler, D.A.1    Compston, A.2    Sawcer, S.3
  • 86
    • 33646712168 scopus 로고    scopus 로고
    • APOE epsilon variation in multiple sclerosis susceptibility and disease severity: Some answers
    • Burwick R. M., Ramsay P. P., Haines J. L., APOE epsilon variation in multiple sclerosis susceptibility and disease severity: some answers Neurology 2006 66 9 1373 1383
    • (2006) Neurology , vol.66 , Issue.9 , pp. 1373-1383
    • Burwick, R.M.1    Ramsay, P.P.2    Haines, J.L.3
  • 87
    • 62549121149 scopus 로고    scopus 로고
    • A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility
    • Bonetti A., Koivisto K., Pirttil T., A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility Journal of Neuroimmunology 2009 208 1-2 119 124
    • (2009) Journal of Neuroimmunology , vol.208 , Issue.12 , pp. 119-124
    • Bonetti, A.1    Koivisto, K.2    Pirttil, T.3
  • 88
    • 18244367936 scopus 로고    scopus 로고
    • Association of polymorphisms in the apolipoprotein e region with susceptibility to and progression of multiple sclerosis
    • Schmidt S., Barcellos L. F., DeSombre K., Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis American Journal of Human Genetics 2002 70 3 708 717
    • (2002) American Journal of Human Genetics , vol.70 , Issue.3 , pp. 708-717
    • Schmidt, S.1    Barcellos, L.F.2    Desombre, K.3
  • 89
    • 51549089652 scopus 로고    scopus 로고
    • Analysis of the association of allelic variants of apolypoprotein e and interleukin 1 beta genes with multiple sclerosis in ethnic Tatars
    • Mustafina O. E., Bakhtiiarova K. Z., Mikhlova A. M., Analysis of the association of allelic variants of apolypoprotein E and interleukin 1 beta genes with multiple sclerosis in ethnic Tatars Genetika 2008 44 3 407 413
    • (2008) Genetika , vol.44 , Issue.3 , pp. 407-413
    • Mustafina, O.E.1    Bakhtiiarova, K.Z.2    Mikhlova, A.M.3
  • 90
    • 33846904026 scopus 로고    scopus 로고
    • APOE genotypes in African American female multiple sclerosis patients
    • Huang R., Hughes M., Mobley S., Lanham I., Poduslo S. E., APOE genotypes in African American female multiple sclerosis patients Neuroscience Letters 2007 414 1 51 56
    • (2007) Neuroscience Letters , vol.414 , Issue.1 , pp. 51-56
    • Huang, R.1    Hughes, M.2    Mobley, S.3    Lanham, I.4    Poduslo, S.E.5
  • 91
    • 0035852833 scopus 로고    scopus 로고
    • APOE genotype is a major predictor of long-term progression of disability in MS
    • Chapman J., Vinokurov S., Achiron A., APOE genotype is a major predictor of long-term progression of disability in MS Neurology 2001 56 3 312 316
    • (2001) Neurology , vol.56 , Issue.3 , pp. 312-316
    • Chapman, J.1    Vinokurov, S.2    Achiron, A.3
  • 92
    • 0034704408 scopus 로고    scopus 로고
    • Association of apolipoprotein e polymorphism to clinical heterogeneity of multiple sclerosis
    • Ballerini C., Campani D., Rombol G., Association of apolipoprotein E polymorphism to clinical heterogeneity of multiple sclerosis Neuroscience Letters 2000 296 2-3 174 176
    • (2000) Neuroscience Letters , vol.296 , Issue.23 , pp. 174-176
    • Ballerini, C.1    Campani, D.2    Rombol, G.3
  • 93
    • 0037227455 scopus 로고    scopus 로고
    • Lower levels of N-acetylaspartate in multiple sclerosis patients with the apolipoprotein e 4 allele
    • Enzinger C., Ropele S., Strasser-Fuchs S., Lower levels of N-acetylaspartate in multiple sclerosis patients with the apolipoprotein E 4 allele Archives of Neurology 2003 60 1 65 70
    • (2003) Archives of Neurology , vol.60 , Issue.1 , pp. 65-70
    • Enzinger, C.1    Ropele, S.2    Strasser-Fuchs, S.3
  • 95
    • 16544363161 scopus 로고    scopus 로고
    • Genotypes at the APOE and SCA2 loci do not predict the course of multiple sclerosis in patients of Portuguese origin
    • Santos M., do Carmo Costa M., Edite Rio M., Genotypes at the APOE and SCA2 loci do not predict the course of multiple sclerosis in patients of Portuguese origin Multiple Sclerosis 2004 10 2 153 157
    • (2004) Multiple Sclerosis , vol.10 , Issue.2 , pp. 153-157
    • Santos, M.1    Do Carmo Costa, M.2    Edite Rio, M.3
  • 96
    • 10744233556 scopus 로고    scopus 로고
    • Association of APOE polymorphisms with disease severity in MS is limited to women
    • Kantarci O. H., Hebrink D. D., Achenbach S. J., Association of APOE polymorphisms with disease severity in MS is limited to women Neurology 2004 62 5 811 814
    • (2004) Neurology , vol.62 , Issue.5 , pp. 811-814
    • Kantarci, O.H.1    Hebrink, D.D.2    Achenbach, S.J.3
  • 97
    • 31644431674 scopus 로고    scopus 로고
    • No association of apolipoprotein e 4 genotype with faster progression or less recovery of relapses in a Spanish cohort of multiple sclerosis
    • Sedano Ma. J., Calmarza P., Perez L., Trejo J. M., No association of apolipoprotein E 4 genotype with faster progression or less recovery of relapses in a Spanish cohort of multiple sclerosis Multiple Sclerosis 2006 12 1 13 18
    • (2006) Multiple Sclerosis , vol.12 , Issue.1 , pp. 13-18
    • Sedano, Ma.J.1    Calmarza, P.2    Perez, L.3    Trejo, J.M.4
  • 98
    • 0043125608 scopus 로고    scopus 로고
    • Polymorphisms of apolipoprotein E and Japanese patients with multiple sclerosis
    • DOI 10.1191/1352458503ms934oa
    • Niino M., Kikuchi S., Fukazawa T., Yabe I., Tashiro K., Polymorphisms of apolipoprotein E and Japanese patients with multiple sclerosis Multiple Sclerosis 2003 9 4 382 386 (Pubitemid 36958021)
    • (2003) Multiple Sclerosis , vol.9 , Issue.4 , pp. 382-386
    • Niino, M.1    Kikuchi, S.2    Fukazawa, T.3    Yabe, I.4    Tashiro, K.5
  • 99
    • 33947146549 scopus 로고    scopus 로고
    • APOE genotypes in Greek multiple sclerosis patients: No effect on the MS Severity Score
    • Koutsis G., Panas M., Karadima G., APOE genotypes in Greek multiple sclerosis patients: No effect on the MS Severity Score Journal of Neurology 2007 254 3 394 395
    • (2007) Journal of Neurology , vol.254 , Issue.3 , pp. 394-395
    • Koutsis, G.1    Panas, M.2    Karadima, G.3
  • 100
    • 70349673166 scopus 로고    scopus 로고
    • Apolipoprotein genotype does not influence MS severity, cognition, or brain atrophy
    • van der Walt A., Stankovich J., Bahlo M., Apolipoprotein genotype does not influence MS severity, cognition, or brain atrophy Neurology 2009 73 13 1018 1025
    • (2009) Neurology , vol.73 , Issue.13 , pp. 1018-1025
    • Van Der Walt, A.1    Stankovich, J.2    Bahlo, M.3
  • 101
    • 3042555152 scopus 로고    scopus 로고
    • No major association of ApoE genotype with disease characteristics and MRI findings in multiple sclerosis
    • Zwemmer J. N.P., van Veen T., van Winsen L., No major association of ApoE genotype with disease characteristics and MRI findings in multiple sclerosis Multiple Sclerosis 2004 10 3 272 277
    • (2004) Multiple Sclerosis , vol.10 , Issue.3 , pp. 272-277
    • Zwemmer, J.N.P.1    Van Veen, T.2    Van Winsen, L.3
  • 103
    • 0035996209 scopus 로고    scopus 로고
    • Disease severity in Danish multiple sclerosis patients evaluated by MRI and three genetic markers (HLA-DRBI 1501, CCR5 deletion mutation, apolipoprotein E)
    • Schreiber K., Oturai A. B., Ryder L. P., Disease severity in Danish multiple sclerosis patients evaluated by MRI and three genetic markers (HLA-DRBI 1501, CCR5 deletion mutation, apolipoprotein E) Multiple Sclerosis 2002 8 4 295 298
    • (2002) Multiple Sclerosis , vol.8 , Issue.4 , pp. 295-298
    • Schreiber, K.1    Oturai, A.B.2    Ryder, L.P.3
  • 104
    • 1642366079 scopus 로고    scopus 로고
    • Accelerated evolution of brain atrophy and black holes in MS patients with APOE- 4
    • Enzinger C., Ropele S., Smith S., Accelerated evolution of brain atrophy and black holes in MS patients with APOE- 4 Annals of Neurology 2004 55 4 563 569
    • (2004) Annals of Neurology , vol.55 , Issue.4 , pp. 563-569
    • Enzinger, C.1    Ropele, S.2    Smith, S.3
  • 106
    • 13244277452 scopus 로고    scopus 로고
    • HLA-DR,DQ and APOE genotypes and gender influence in Sardinian primary progressive MS
    • Cocco E., Sotgiu A., Costa G., HLA-DR,DQ and APOE genotypes and gender influence in Sardinian primary progressive MS Neurology 2005 64 3 564 566
    • (2005) Neurology , vol.64 , Issue.3 , pp. 564-566
    • Cocco, E.1    Sotgiu, A.2    Costa, G.3
  • 107
    • 0141832048 scopus 로고    scopus 로고
    • Apolipoprotein e genotype does not influence the progression of multiple sclerosis
    • Savettieri G., Andreoli V., Bonavita S., Apolipoprotein E genotype does not influence the progression of multiple sclerosis Journal of Neurology 2003 250 9 1094 1098
    • (2003) Journal of Neurology , vol.250 , Issue.9 , pp. 1094-1098
    • Savettieri, G.1    Andreoli, V.2    Bonavita, S.3
  • 108
    • 25844450924 scopus 로고    scopus 로고
    • Apo e in multiple sclerosis and optic neuritis: The Apo E- 4 allele is associated with progression of multiple sclerosis
    • Pinholt M., Frederiksen J. L., Andersen P. S., Christiansen M., Apo E in multiple sclerosis and optic neuritis: the Apo E- 4 allele is associated with progression of multiple sclerosis Multiple Sclerosis 2005 11 5 511 515
    • (2005) Multiple Sclerosis , vol.11 , Issue.5 , pp. 511-515
    • Pinholt, M.1    Frederiksen, J.L.2    Andersen, P.S.3    Christiansen, M.4
  • 109
    • 34248668730 scopus 로고    scopus 로고
    • No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis
    • Ramagopalan S. V., DeLuca G. C., Morrison K. M., No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis Journal of Neuroimmunology 2007 186 1-2 156 160
    • (2007) Journal of Neuroimmunology , vol.186 , Issue.12 , pp. 156-160
    • Ramagopalan, S.V.1    Deluca, G.C.2    Morrison, K.M.3
  • 110
    • 0025777432 scopus 로고
    • Cognitive dysfunction in multiple sclerosis. II. Impact on employment and social functioning
    • Rao S. M., Leo G. J., Ellington L., Nauertz T., Bernardin L., Unverzagt F., Cognitive dysfunction in multiple sclerosis. II. Impact on employment and social functioning Neurology 1991 41 5 692 696
    • (1991) Neurology , vol.41 , Issue.5 , pp. 692-696
    • Rao, S.M.1    Leo, G.J.2    Ellington, L.3    Nauertz, T.4    Bernardin, L.5    Unverzagt, F.6
  • 111
    • 0025731153 scopus 로고
    • Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction
    • Rao S. M., Leo G. J., Bernardin L., Unverzagt F., Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction Neurology 1991 41 5 685 691
    • (1991) Neurology , vol.41 , Issue.5 , pp. 685-691
    • Rao, S.M.1    Leo, G.J.2    Bernardin, L.3    Unverzagt, F.4
  • 112
    • 38149003882 scopus 로고    scopus 로고
    • APOE 4 allele is associated with cognitive impairment in patients with multiple sclerosis
    • Shi J., Zhao C. B., Vollmer T. L., Tyry T. M., Kuniyoshi S. M., APOE 4 allele is associated with cognitive impairment in patients with multiple sclerosis Neurology 2008 70 3 185 190
    • (2008) Neurology , vol.70 , Issue.3 , pp. 185-190
    • Shi, J.1    Zhao, C.B.2    Vollmer, T.L.3    Tyry, T.M.4    Kuniyoshi, S.M.5
  • 113
    • 8744251003 scopus 로고    scopus 로고
    • Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis
    • Savettieri G., Messina D., Andreoli V., Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis Journal of Neurology 2004 251 10 1208 1214
    • (2004) Journal of Neurology , vol.251 , Issue.10 , pp. 1208-1214
    • Savettieri, G.1    Messina, D.2    Andreoli, V.3
  • 114
    • 33847196388 scopus 로고    scopus 로고
    • APOE 4 is associated with impaired verbal learning in patients with MS
    • Koutsis G., Panas M., Giogkaraki E., APOE 4 is associated with impaired verbal learning in patients with MS Neurology 2007 68 8 546 549
    • (2007) Neurology , vol.68 , Issue.8 , pp. 546-549
    • Koutsis, G.1    Panas, M.2    Giogkaraki, E.3
  • 115
    • 38149009814 scopus 로고    scopus 로고
    • MS and cognition and APOE: The ongoing conundrum about biomarkers
    • Sadovnick A. D., Jacobs D. H., MS and cognition and APOE: the ongoing conundrum about biomarkers Neurology 2008 70 3 164 165
    • (2008) Neurology , vol.70 , Issue.3 , pp. 164-165
    • Sadovnick, A.D.1    Jacobs, D.H.2
  • 116
    • 0034720256 scopus 로고    scopus 로고
    • Brain MRI lesions and atrophy are related to depression in multiple sclerosis
    • Bakshi R., Czarnecki D., Shaikh Z. A., Brain MRI lesions and atrophy are related to depression in multiple sclerosis NeuroReport 2000 11 6 1153 1158
    • (2000) NeuroReport , vol.11 , Issue.6 , pp. 1153-1158
    • Bakshi, R.1    Czarnecki, D.2    Shaikh, Z.A.3
  • 117
    • 0034081982 scopus 로고    scopus 로고
    • Lesion pattern in patients with multiple sclerosis and depression
    • Berg D., Supprian T., Thomae J., Lesion pattern in patients with multiple sclerosis and depression Multiple Sclerosis 2000 6 3 156 162
    • (2000) Multiple Sclerosis , vol.6 , Issue.3 , pp. 156-162
    • Berg, D.1    Supprian, T.2    Thomae, J.3
  • 120
    • 0023103081 scopus 로고
    • Alterations in plasma lipoproteins and apolipoproteins in experimental allergic encephalomyelitis
    • Shore V. G., Smith M. E., Perret V., Laskaris M. A., Alterations in plasma lipoproteins and apolipoproteins in experimental allergic encephalomyelitis Journal of Lipid Research 1987 28 2 119 129
    • (1987) Journal of Lipid Research , vol.28 , Issue.2 , pp. 119-129
    • Shore, V.G.1    Smith, M.E.2    Perret, V.3    Laskaris, M.A.4
  • 121
    • 0142091857 scopus 로고    scopus 로고
    • Lack of apolipoprotein-E exacerbates experimental allergic encephalomyelitis
    • Karussis D., Michaelson D. M., Grigoriadis N., Lack of apolipoprotein-E exacerbates experimental allergic encephalomyelitis Multiple Sclerosis 2003 9 5 476 480
    • (2003) Multiple Sclerosis , vol.9 , Issue.5 , pp. 476-480
    • Karussis, D.1    Michaelson, D.M.2    Grigoriadis, N.3
  • 122
    • 0037424260 scopus 로고    scopus 로고
    • Novel role for apolipoprotein e in the central nervous systemml: Modulation of sulfatide content
    • Han X., Cheng H., Fryer J. D., Fagan A. M., Holtzman D. M., Novel role for apolipoprotein E in the central nervous systemml: modulation of sulfatide content The Journal of Biological Chemistry 2003 278 10 8043 8051
    • (2003) The Journal of Biological Chemistry , vol.278 , Issue.10 , pp. 8043-8051
    • Han, X.1    Cheng, H.2    Fryer, J.D.3    Fagan, A.M.4    Holtzman, D.M.5
  • 123
    • 32344431845 scopus 로고    scopus 로고
    • Serum lipoproteins: Trojan horses of the immune response?
    • Schmann J., De Libero G., Serum lipoproteins: trojan horses of the immune response? Trends in Immunology 2006 27 2 57 59
    • (2006) Trends in Immunology , vol.27 , Issue.2 , pp. 57-59
    • Schmann, J.1    De Libero, G.2
  • 124
    • 33747620317 scopus 로고    scopus 로고
    • Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis
    • Li F.-Q., Sempowski G. D., McKenna S. E., Laskowitz D. T., Colton C. A., Vitek M. P., Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis The Journal of Pharmacology and Experimental Therapeutics 2006 318 3 956 965
    • (2006) The Journal of Pharmacology and Experimental Therapeutics , vol.318 , Issue.3 , pp. 956-965
    • Li, F.-Q.1    Sempowski, G.D.2    McKenna, S.E.3    Laskowitz, D.T.4    Colton, C.A.5    Vitek, M.P.6
  • 125
    • 0035152093 scopus 로고    scopus 로고
    • Downregulation of microglial activation by apolipoprotein e and apoE-mimetic peptides
    • Laskowitz D. T., Thekdi A. D., Thekdi S. D., Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides Experimental Neurology 2001 167 1 74 85
    • (2001) Experimental Neurology , vol.167 , Issue.1 , pp. 74-85
    • Laskowitz, D.T.1    Thekdi, A.D.2    Thekdi, S.D.3
  • 127
    • 38149003882 scopus 로고    scopus 로고
    • APOE 4 allele is associated with cognitive impairment in patients with multiple sclerosis
    • Shi J., Zhao C. B., Vollmer T. L., Tyry T. M., Kuniyoshi S. M., APOE 4 allele is associated with cognitive impairment in patients with multiple sclerosis Neurology 2008 70 3 185 190
    • (2008) Neurology , vol.70 , Issue.3 , pp. 185-190
    • Shi, J.1    Zhao, C.B.2    Vollmer, T.L.3    Tyry, T.M.4    Kuniyoshi, S.M.5
  • 128
    • 28544450761 scopus 로고    scopus 로고
    • Experimental allergic encephalomyelitis: A misleading model of multiple sclerosis
    • Sriram S., Steiner I., Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis Annals of Neurology 2005 58 6 939 945
    • (2005) Annals of Neurology , vol.58 , Issue.6 , pp. 939-945
    • Sriram, S.1    Steiner, I.2
  • 129
    • 0029844205 scopus 로고    scopus 로고
    • Human apolipoprotein E: The Alzheimer's disease connection
    • Weisgraber K. H., Mahley R. W., Human apolipoprotein E: the Alzheimer's disease connection The FASEB Journal 1996 10 13 1485 1494
    • (1996) The FASEB Journal , vol.10 , Issue.13 , pp. 1485-1494
    • Weisgraber, K.H.1    Mahley, R.W.2
  • 131
    • 0025171570 scopus 로고
    • Apolipoprotein e distribution among human plasma lipoproteins: Role of the cysteine-arginine interchange at residue 112
    • Weisgraber K. H., Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112 Journal of Lipid Research 1990 31 8 1503 1511
    • (1990) Journal of Lipid Research , vol.31 , Issue.8 , pp. 1503-1511
    • Weisgraber, K.H.1
  • 132
    • 0018800929 scopus 로고
    • Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts
    • Innerarity T. L., Pitas R. E., Mahley R. W., Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts The Journal of Biological Chemistry 1979 254 10 4186 4190
    • (1979) The Journal of Biological Chemistry , vol.254 , Issue.10 , pp. 4186-4190
    • Innerarity, T.L.1    Pitas, R.E.2    Mahley, R.W.3
  • 133
    • 0141742030 scopus 로고    scopus 로고
    • Cellular catabolism of lipid poor apolipoprotein e via cell surface LDL receptor-related protein
    • Narita M., Holtzman D. M., Fagan A. M., Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein Journal of Biochemistry 2002 132 5 743 749
    • (2002) Journal of Biochemistry , vol.132 , Issue.5 , pp. 743-749
    • Narita, M.1    Holtzman, D.M.2    Fagan, A.M.3
  • 134
    • 34147152755 scopus 로고    scopus 로고
    • The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE 4 allele increases the risk of late-onset alzheimer disease
    • Wang B., Jin F., Yang Z., The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE 4 allele increases the risk of late-onset alzheimer disease Journal of Molecular Neuroscience 2006 30 3 267 271
    • (2006) Journal of Molecular Neuroscience , vol.30 , Issue.3 , pp. 267-271
    • Wang, B.1    Jin, F.2    Yang, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.